I-Dimethylfraxetin ;6,7,8-Trimethoxycoumarin
Ukucaciswa Komkhiqizo
Igama Elivamile:isihlahla somlotha element
Inombolo ye-CAS:6035-49-0
Ukuminyana:1.2 ± 0.1 g / cm3
I-Molecular Formula:I-C12H12O5
I-MSDS:N/A
Igama lesiNgisi:I-dimethylfraxetin
Isisindo se-Molecular:236.221
Indawo yokubilisa:408.0 ± 45.0 ° C ku-760 mmHg
I-Melting Point:104-105 º C
I-Flash Point:184.3 ± 28.8 ° C
Umsebenzi webhayoloji we-dimethylfraxetin
Incazelo:I-dimethylfraxetin iyi-carbonic anhydrase inhibitor enenani le-Ki elingu-0.0097 μ M.
Izigaba Ezihlobene:
indlela yesignali > > i-enzyme ye-metabolic / i-protease > > i-carbonic anhydrase
Umkhakha wocwaningo > > umdlavuza
Imikhiqizo yemvelo > > ama-benzoic acid
Ithagethi:ki: 0.0097 μ M (Carbonic anhydrase)[1]
Isifundo se-in vitro:ku-CA I, inhlanganisela eyodwa evelele yi-dimethylfluoxetine (inhlanganisela engu-17), i-nanomolar CA I inhibitor.Le trimethoxycoumarin iphumelela kakhulu kunoma iyiphi i-NP coumarin phakathi kwama-isozyme e-CA ayisithupha kulolu cwaningo [1].
Kinase:Ngaphambi kokunquma, i-inhibitor (kuhlanganise ne-dimethylerythromycin) kanye nesisombululo se-enzyme kwakufakwe ngaphambili ekamelweni lokushisa amahora angu-6 ukuvumela ukwakheka kwe-enzyme inhibitor complex [1]
Izithenjwa:[1] UDavis RA, et al.Ama-coumarin omkhiqizo wemvelo avimbela ama-carbonic anhydrases womuntu.Bioorg Med Chem.2013 Mar 15;21(6):1539-43.
I-Dimethylfraxetin
Ukuminyana:1.2 ± 0.1 g / cm3
Indawo yokubilisa:408.0 ± 45.0 ° C ku-760 mmHg
I-Melting Point:104-105 º C
I-Molecular Formula:c12h12o5
Isisindo se-Molecular:236.221
I-Flash Point:184.3 ± 28.8 ° C
IMisa Elinembile:236.068466
I-PSA:57.90000
I-LogP:1.75
I-Steam Pressure:0.0 ± 1.0 mmHg ku-25 ° C
Inkomba ye-refractive:1.545
Ulwazi Lokuphepha lwe-Dimethylfraxetin
Isitatimende sobungozi (eYurophu): 22
Isitatimende sokuphepha (eYurophu):22-45
Ikhodi Yesiko:293220990
Imikhiqizo ye-Dimethylfraxetin Upstream And Downstream
Imikhiqizo ye-DDimethylfraxetin Upstream
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Imikhiqizo ye-DDimethylfraxetin Downstream
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I-Dimethylfraxetin Customs
Ikhodi Yesiko:293220990
Uhlolojikelele lwesiShayina:293220990 Izinga le-VAT lamanye ama-lactones: 17.0% Izinga lesaphulelo sentela: 13.0% Izimo zokulawula: ayikho Imali ye-MFN: 6.5% Intengo evamile: 20.0%
Izici zesimemezelo:igama lomkhiqizo, ukwakheka, okuqukethwe kanye nenjongo
Isifinyezo:2932209090. amanye ama-lactone.I-VAT:17.0%.Izinga lesaphulelo sentela:13.0%..Intengo ye-MFN:6.5%.Intengo ejwayelekile:20.0%
I-Alias yesiNgisi ye-Dimethylfraxetin
6,7,8-trimethoxychromen-2-one
6,7,8-Trimethoxy-2H-chromen-2-one
2H-1-Benzopyran-2-one, 6,7,8-trimethoxy-
