Dimethylfraxetin;6,7,8-Trimethoxycoumarin
Tlhaloso ea Sehlahisoa
Lebitso le Tloaelehileng:molora sefate element
Nomoro ea CAS:6035-49-0
Tekano:1.2 ± 0.1 g / cm3
Foromo ea molek'hule:C12H12O5
MSDS:N/A
Lebitso la Senyesemane:dimethylfraxetin
Boima ba Molek'hule:236.221
Sebaka sa ho Bela:408.0 ± 45.0 ° C ho 760 mmHg
Melting Point:104-105 ºC
Flash point:184.3 ± 28.8 ° C
Ts'ebetso ea bioloji ea dimethylfraxetin
Tlhaloso:dimethylfraxetin ke carbonic anhydrase inhibitor e nang le boleng ba Ki ea 0.0097 μ M.
Lihlopha tse amanang:
tsela ea pontšo>> enzyme ea metabolic / protease>> carbonic anhydrase
Sebaka sa lipatlisiso> > kankere
Lihlahisoa tsa Tlhaho > > li-benzoic acid
Sepheo:ki: 0.0097 μ M (Carbonic anhydrase)[1]
Thuto ea in vitro:ho CA I, motsoako o mong o hlahelletseng ke dimethylfluoxetine (motsoako oa 17), e leng nanomolar CA I inhibitor.Trimethoxycoumarin ena ke eona e sebetsang ka ho fetisisa ho NP coumarin efe kapa efe har'a li-isozyme tse tšeletseng tsa CA thutong ena [1].
Kinase:pele ho etsoa qeto, inhibitor (ho kenyeletsoa dimethylerythromycin) le tharollo ea enzyme li ne li kentsoe pele mocheso oa kamore bakeng sa lihora tse 6 ho lumella ho thehoa ha enzyme inhibitor complex [1]
Litšupiso:[1] Davis RA, et al.Li-coumarins tsa lihlahisoa tsa tlhaho tse thibelang li-anhydrase tsa carbonic tsa motho.Bioorg Med Chem.2013 Mar 15;21(6):1539-43.
Dimethylfraxetin
Tekano:1.2 ± 0.1 g / cm3
Sebaka sa ho Bela:408.0 ± 45.0 ° C ho 760 mmHg
Melting Point:104-105 ºC
Foromo ea molek'hule:c12h12o5
Boima ba Molek'hule:236.221
Flash point:184.3 ± 28.8 ° C
'Misa o nepahetseng:236.068466
PSA:57.90000
LogP:1.75
Khatello ea Mouoane:0.0 ± 1.0 mmHg ho 25 ° C
Lenane la Refractive:1.545
Boitsebiso ba Tšireletso ea Dimethylfraxetin
Polelo ea kotsi (Europe): 22
Polelo ea polokeho (Europe):22-45
Khoutu ya Dikgetho:293220990
Dimethylfraxetin Lihlahisoa tse ka holimo le tse tlaase
Lihlahisoa tsa DDimethylfraxetin Upstream
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Lihlahisoa tsa DDimethylfraxetin Downstream
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Dimethylfraxetin Mekhoa
Khoutu ya Dikgetho:293220990
Kakaretso ea Sechaena:293220990 Sekgahla sa VAT sa lactone tse ding: 17.0% Sekgahla sa phokotso ya Lekgetho: 13.0% Maemo a taolo: ha ho na ditefiso tsa MFN: 6.5% Tefiso e akaretsang: 20.0%
Lintlha tsa phatlalatso:lebitso la sehlahiswa, tlhamo, dikahare le morero
Kakaretso:2932209090. lactone tse ling.VAT:17.0%.Sekhahla sa phokotso ea lekhetho:13.0%..Litefiso tsa MFN: 6.5%.Litefiso tse akaretsang: 20.0%
Letšoao la Senyesemane la Dimethylfraxetin
6,7,8-trimethoxychromen-2-one
6,7,8-Trimethoxy-2H-chromen-2-one
2H-1-Benzopyran-2-one, 6,7,8-trimethoxy-
