Kayayyaki

Naringin shine aglycone na naringin kuma yana cikin dihydroflavonoids.Yana yana da ayyuka na antibacterial, anti-mai kumburi, free radical scavenging, antioxidant, tari da expectorant, jini ragewan jini, anti-cancer, anti-tumor, antispasmodic da cholagogic, rigakafi da kuma lura da hanta cututtuka, hana platelet coagulation, anti-mai kumburi. atherosclerosis da sauransu.Ana iya amfani da shi sosai a magani, abinci da sauran fannoni.

Kwayoyin cuta
Yana da tasirin antibacterial mai ƙarfi akan Staphylococcus aureus, Escherichia coli, dysentery da typhoid bacillus.Naringin kuma yana da tasiri akan fungi.Fesa 1000ppm akan shinkafa na iya rage kamuwa da cutar Magnaporthe grisea da kashi 40-90%, kuma ba shi da wani guba ga mutane da dabbobi.

Anti kumburi
An yi wa berayen allura ta ciki da 20mg/kg a kowace rana, wanda ya hana aiwatar da kumburin ƙwayar cuta ta hanyar sanya ƙwallon ulu.Galati et al.An gano cewa kowane rukunin kashi na naringin yana da tasirin anti-mai kumburi ta hanyar gwajin kwamfutar hannu ta linzamin kwamfuta, kuma tasirin anti-mai kumburi ya karu tare da karuwar kashi.Matsakaicin hani na babban kashi shine 30.67% tare da bambancin kauri da 38% tare da bambancin nauyi.[4] Feng Baomin et al.Ƙaddamar da lokaci na 3 dermatitis a cikin mice ta hanyar DNFB, sa'an nan kuma ya ba da naringin baki don 2 ~ 8 kwanaki don kiyaye ƙimar hanawa na lokaci-lokaci (IPR), ƙarshen lokaci (LPR) da ultra late lokaci (VLPR).Naringin zai iya hana kumburin kunne na IPR da VLPR yadda ya kamata, kuma yana da ƙimar ci gaba a cikin maganin kumburi.

Tsarin rigakafi
Naringin yana kula da ma'auni mai dacewa na matsa lamba oxidative a cikin takamaiman lokaci da takamaiman yankuna ta hanyar daidaita kwararar electrons a cikin mitochondria.Saboda haka, aikin immunomodulatory na naringin ya bambanta da masu haɓaka rigakafi masu sauƙi na gargajiya ko magungunan rigakafi.Halinsa shine zai iya mayar da yanayin rashin daidaituwa (jihar pathological) zuwa yanayin ma'auni na rigakafi na kusa (jihar ilimin lissafi), Maimakon haɓakawa gaba ɗaya ko hana amsawar rigakafi.

Tsarin hailar mace
Naringin yana da aiki mai kama da waɗanda ba steroidal anti-inflammatory kwayoyi.Yana iya rage kira na prostaglandin PGE2 ta hanyar hana cyclooxygenase Cox, kuma yana taka rawar antipyretic, analgesic da rage kumburi.
Dangane da isrogen kamar tasirin naringin, naringin za a iya amfani dashi don maganin maye gurbin estrogen a cikin matan da suka shude don guje wa mummunan halayen da ke haifar da amfani da estrogen na dogon lokaci.

Tasiri akan kiba
Naringin yana da tabbataccen tasirin warkewa akan hyperlipidemia da kiba.
Naringin na iya inganta haɓakar ƙwayar cholesterol mai girma a cikin plasma, taro na TG (triglyceride) da kuma tattarawar fatty acid kyauta a cikin berayen masu kiba.An gano cewa naringin zai iya daidaita mai karɓar mai karɓa na monocyte peroxisome proliferator a cikin berayen ƙirar ƙiba δ, Rage matakin lipid na jini.
Ta hanyar gwaje-gwajen asibiti, an gano cewa marasa lafiya da ke da hypercholesterolemia sun ɗauki capsule guda ɗaya mai ɗauke da 400mg naringin kowace rana har tsawon makonni 8.Matsakaicin TC da LDL cholesterol a cikin jini ya ragu, amma yawan adadin cholesterol na TG da HDL bai canza sosai ba.
A ƙarshe, naringin zai iya inganta hyperlipidemia, wanda aka tabbatar da kyau a cikin gwaje-gwajen dabba da gwaji na asibiti.

Scavenging free radicals da antioxidation
DPPH (dibenzo mai ɗaci acyl radical) tsayayyiyar tsattsauran ra'ayi ne.Za a iya kimanta ikonta na ɓata radicals kyauta ta hanyar rage ɗaukar nauyin 517 nm.[6] Kroyer yayi nazarin tasirin antioxidant na naringin ta hanyar gwaje-gwaje kuma ya tabbatar da cewa naringin yana da tasirin antioxidant.[7] Zhang Haide et al.An gwada aikin lipid peroxidation na LDL ta hanyar launi da kuma ikon hana gyaran oxidative na LDL.Naringin yafi chelates Cu2 + ta 3-hydroxyl da 4-carbonyl kungiyoyin, ko samar da proton da free radical neutralization, ko kare LDL daga lipid peroxidation ta hanyar iskar oxygenation.Zhang Haide da sauransu sun gano cewa naringin yana da kyakkyawan sakamako mai kyawu ta hanyar DPPH.Za'a iya samun tasirin ɓarkewar ɓacin rai ta hanyar iskar hydrogen oxidation na naringin kanta.[8] Peng Shuhui et al.An yi amfani da samfurin gwaji na haske riboflavin (IR) - nitrotetrazolium chloride (NBT) - spectrophotometry don tabbatar da cewa naringin yana da tasiri mai banƙyama akan nau'in oxygen mai amsawa O2 -, wanda ya fi ƙarfin ascorbic acid a cikin ingantaccen iko.Sakamakon gwaje-gwajen dabba sun nuna cewa naringin yana da tasirin hanawa mai ƙarfi akan lipid peroxidation a cikin kwakwalwar linzamin kwamfuta, zuciya da hanta, kuma yana iya haɓaka aikin superoxide dismutase (SOD) a cikin jini gaba ɗaya.

Kariyar zuciya
Naringin da naringin na iya haɓaka ayyukan acetaldehyde reductase (ADH) da acetaldehyde dehydrogenase (ALDH), rage abubuwan da ke cikin triglycerides a cikin hanta da jimlar cholesterol a cikin jini da hanta, haɓaka abun ciki na babban adadin lipoprotein cholesterol (HDLC), haɓaka rabo. na HDLC zuwa jimlar cholesterol, da kuma rage alamar atherogenic a lokaci guda, Naringin na iya inganta jigilar cholesterol daga plasma zuwa hanta, zubar da bile da fitarwa, kuma ya hana canza HDL zuwa VLDL ko LDL.Don haka, naringin na iya rage haɗarin arteriosclerosis da cututtukan zuciya.Naringin na iya rage abun ciki na jimlar cholesterol a cikin jini kuma yana ƙarfafa metabolism.

Tasirin Hypolipidemie
Zhang Haide et al.Tested serum cholesterol (TC), low density lipoprotein cholesterol (LDL-C), plasma high density lipoprotein cholesterol (HDL-C), triglyceride (TG) da sauran abubuwa na berayen bayan gudanarwa ta cikin jini ta hanyar gwaje-gwajen dabba. serum TC, TG da LDL-C da ingantacciyar ƙara yawan maganin HDL-C a wani ƙayyadadden kashi, yana nuna cewa naringin yana da tasirin rage lipid na jini a cikin mice.[

Ayyukan Antitumor
Naringin na iya daidaita aikin rigakafi kuma yana hana ci gaban ƙari.Naringin yana da aiki akan cutar sankarar bera L1210 da sarcoma.Sakamakon ya nuna cewa girman thymus / nauyin jikin beraye ya karu bayan gudanar da naringin na baki, wanda ke nuna cewa naringin na iya inganta aikin rigakafi na jiki.Naringin na iya daidaita matakin T lymphocytes, gyara raunin garkuwar jiki na biyu wanda ƙari ko radiotherapy da chemotherapy ke haifarwa, da haɓaka tasirin kashe ƙwayoyin cutar kansa.An ba da rahoton cewa naringin na iya ƙara nauyin thymus a cikin ascites ciwon daji masu ɗauke da berayen, yana nuna cewa zai iya inganta aikin rigakafi da kuma motsa ƙarfin maganin ciwon daji na ciki.An gano cewa cirewar kwasfa na pomelo yana da tasiri mai hanawa akan S180 sarcoma, kuma adadin hana ƙwayar ƙwayar cuta shine 29.7%.

Antispasmodic da cholagogic
Yana da tasiri mai karfi a cikin flavonoids.Naringin kuma yana da tasiri mai ƙarfi akan haɓaka ƙwayar bile na dabbobin gwaji.

Antitussive And Expectorant Tasiri
Yin amfani da phenol ja a matsayin mai nuna alamar kawar da cututtuka, gwajin ya nuna cewa naringin yana da tari mai karfi da kuma tasirin fata.

Aikace-aikacen asibiti
Ana amfani da shi don magance cututtukan ƙwayoyin cuta, maganin kwantar da hankali da magungunan ciwon daji.
Tsarin sashi na aikace-aikacen: suppository, lotion, allura, kwamfutar hannu, capsule, da sauransu.