Methylophiopogonanone A;Opogonanone A
Aikace-aikacen Methylophiopogonanone A
Methylophiopogonanone A shine flavonoid da aka samo daga Ophiopogon japonicas, wanda ke da tasirin antioxidant da anti-mai kumburi.
Sunan Methylophiopogonanone A
Sunan Ingilishi:
(3R) -3- (1,3-benzodioxol-5-ylmethyl) -5,7-dihydroxy-6,8-dimethyl-2,3-dihydrochromen-4-daya
Laƙabin Sinawa:
Ophiopogon methyl flavanone a |methyl Ophiopogon dihydrohomoisoflavone a |methyl Ophiopogon flavanone a
Ayyukan Halitta na Methylophiopogonanone A
Bayani: methylophiopogonanone A shine flavonoid da aka samo daga Ophiopogon japonicas, wanda ya
antioxidant da anti-mai kumburi sakamako.
Rukunin da ke da alaƙa: Hanyar sigina > > apoptosis > > apoptosis
filin bincike > > kumburi / rigakafi
A cikin Nazarin Vitro: methyl aspartate a (mo-a; 10 μ Mo (L / L) ya rage raguwar apoptosis da maganganun Caspase-3, ya karu Bcl-2 / Bax rabo kuma ba a dawo da shi ba. Methylaspartate a (mo-a) pretreatment
yana haɓaka haɓakar hanyar PI3K / Akt / eNOS a cikin sel H9c2 a ƙarƙashin H / R, yayin da aka soke tasirin kariya na mo-a a gaban PI3K inhibitor wortmannin (100 nmol / L) [1].
A cikin Nazarin Vivo: Sakamakon kariya na methylaspartate a (mo-a; 10mg / kg / D, PO) akan aikin zuciya bayan rauni na I / R na myocardial [1].
Nassoshi: [1] He F, et al.Methylophiopogonanone A yana hana ischemia / reperfusion-induced myocardial apoptosis a cikin mice ta hanyar kunna hanyar siginar PI3K/Akt/eNOS.Acta Pharmacol Sin.2016 Juni;37 (6): 763-71.
Physicochemical Properties na Methylophiopogonanone A
Girma: 1.4 ± 0.1 g / cm3
Tushen tafasa: 580.1 ± 50.0 ° C a 760 mmHg
Tsarin kwayoyin halitta: c19h18o6
Nauyin Kwayoyin: 342.343
Wutar Wuta: 212.9 ± 23.6 ° C
Daidai Mass: 342.110352
Saukewa: 85.22000
Shafin: 5.16
Matsin lamba: 0.0 ± 1.7 mmHg a 25 ° C
Shafin Farko: 1.654
Sunan Ingilishi na Methylophiopogonanone A
(1,3-Benzodioxol-5-ylmethyl) -5,7-dihydroxy-6,8-dimethyl-2,3-dihydro-4H-chromen-4-daya
4H-1-Benzopyran-4-daya, 3- (1,3-benzodioxol-5-ylmethyl) -2,3-dihydro-5,7-dihydroxy-6,8-dimethyl-
N1002
Methylophiopogonanone A
Sabis na Yongjian
Sabis na Musamman Na Abubuwan Tunanin Sinadarai Na Magungunan Sinawa na Gargajiya
Jiangsu Yongjian Pharmaceutical Technology Co., Ltd. ya fi tsunduma cikin bincike na asali na abubuwa masu aiki na magungunan gargajiya na kasar Sin fiye da shekaru goma.Ya zuwa yanzu, kamfanin ya gudanar da zurfafa bincike a kan nau'o'in magungunan gargajiya na kasar Sin fiye da 100 da aka saba amfani da su, tare da hako dubban sinadarai.
Kamfanin yana da manyan ma'aikatan R & D da cikakkun kayan aikin gwaji da bincike a cikin masana'antar, kuma ya yi hidima ga ɗaruruwan cibiyoyin bincike na kimiyya.Yana iya sauri da inganci ya dace da bukatun abokan ciniki
Sabis na Tabbatar da Tsabtace Magunguna, Shirye-shiryen da Tsari
Najasa a cikin magunguna suna da alaƙa da inganci, aminci da kwanciyar hankali na magunguna.Shirye-shiryen da tsarin tabbatar da ƙazanta a cikin magunguna na iya taimaka mana mu fahimci hanyoyin ƙazanta da kuma samar da tushen inganta tsarin samarwa.Sabili da haka, shirye-shiryen da rarrabuwa na ƙazanta yana da mahimmanci ga bincike da ci gaban miyagun ƙwayoyi.
Duk da haka, abun ciki na ƙazanta a cikin miyagun ƙwayoyi yana da ƙananan, tushen yana da fadi, kuma tsarin ya fi kama da babban sashi.Wace fasaha za a iya amfani da ita don rarrabewa da tsarkake duk ƙazanta a cikin miyagun ƙwayoyi ɗaya bayan ɗaya da sauri?Wadanne dabaru da hanyoyin da ake amfani da su don tabbatar da tsarin wadannan najasa?Wannan shi ne wahalhalu da kalubalen da kamfanonin harhada magunguna da dama ke fuskanta, musamman ma kamfanonin harhada magunguna na likitanci da likitancin kasar Sin.
Dangane da irin waɗannan buƙatun, kamfanin ya ƙaddamar da ayyukan rabuwa da ƙazantar ƙwayoyi da ayyukan tsarkakewa.Dogaro da ƙarfin maganadisu na magnetic nukiliya, ƙididdigar taro da sauran kayan aiki da fasaha, kamfanin na iya hanzarta gano tsarin mahaɗan da aka raba, don biyan bukatun abokan ciniki.
Gwajin Dabbobin SPF
Wurin ginin filin gwajin dabba shine murabba'in murabba'in mita 1500, gami da murabba'in murabba'in murabba'in 400 na yanki gwajin matakin SPF da murabba'in murabba'in mita 100 na dakin gwaje-gwajen matakin salula na P2.Masana kimiyya na Jami'ar Pharmaceutical na kasar Sin ke jagoranta, ta kafa wata babbar tawagar fasaha tare da adadin masu dawowa.Samar da samfuran dabbobi masu inganci, ƙirar gwaji, ayyukan gabaɗaya da sauran ayyuka don binciken kimiyyar halittu, koyarwa da haɓaka masana'antu.
Girman Kasuwanci
1. Ƙananan ciyar da dabba
2. Tsarin cutar dabbobi
3. Koleji aikin fitar da kayayyaki
4. Pharmacodynamic kimantawa a cikin vivo
5. Pharmacokinetic kimantawa
6. Sabis na gwajin ƙwayar ƙwayar cuta
Karfin Mu
1. Mai da hankali kan gwaje-gwaje na gaske
2. Daidaita daidaitaccen tsari
3. Sanya hannu sosai kan yarjejeniyar sirri
4. Mallakar dakin gwaje-gwaje ba tare da tsaka-tsaki ba
5. Ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun masu sana'a ta tabbatar da ingancin gwaji
Wurin gwaji na SPF, ciyarwar mutum na musamman, ci gaban gwaji na sa ido na ainihi
