Methylophiopogonanone A;Opogonanone A
Faʻaaogaina o le Methylophiopogonanone A
Methylophiopogonanone A o se flavonoid na maua mai le Ophiopogon japonicas, o loʻo i ai le antioxidant ma le anti-inflammatory effects.
Igoa ole Methylophiopogonanone A
Igoa Igilisi:
(3R) -3-(1,3-benzodioxol-5-ylmethyl) -5,7-dihydroxy-6,8-dimethyl-2,3-dihydrochromen-4-one
Fa'aigoa Saina:
Ophiopogon methyl flavanone a |methyl Ophiopogon dihydrohomoisoflavone a |methyl Ophiopogon flavanone a
Gaoioiga faʻaola ole Methylophiopogonanone A
Fa'amatalaga: methylophiopogonanone A o se flavonoid na maua mai le Ophiopogon japonicas, lea e iai
a'afiaga o le antioxidant ma le anti-inflammatory.
Vaega Fa'atatau: ala fa'ailoga > > apoptosis > > apoptosis
matā'upu su'esu'e > > fula / fa'ama'i
Su'esu'ega In Vitro: methyl aspartate a (mo-a; 10 μ Mo (L / L) na matua fa'aitiitia ai le apoptosis ma le fa'aaliga Caspase-3, fa'ateleina le Bcl-2 / Bax ratio ma toe fa'afo'isia leai se gaosiga. Methylaspartate a (mo-a) mua'i togafitiga
faʻaleleia atili le faʻagaoioia o le ala PI3K / Akt / eNOS i sela H9c2 i lalo o le H / R, aʻo faʻaleaogaina le puipuiga o le mo-a i le i ai o le PI3K inhibitor wortmannin (100 nmol / L) [1].
I Vivo Suʻesuʻega: aʻafiaga puipuia o le methylaspartate a (mo-a; 10mg / kg / D, PO) i luga o le gaioiga o le fatu pe a maeʻa le myocardial I / R manua [1].
Fa'amatalaga: [1] He F, et al.Methylophiopogonanone A e taofiofia le ischemia / reperfusion-induced myocardial apoptosis i isumu e ala i le faʻagaoioia PI3K / Akt / eNOS ala faʻailoga.Acta Pharmacol Agasala.2016 Iuni;37(6):763-71.
Amioga fa'aletino ole Methylophiopogonanone A
Malosi: 1.4 ± 0.1 g / cm3
Fa'asao: 580.1 ± 50.0 ° C ile 760 mmHg
Fuafuaga mole: c19h18o6
Molecular Weight: 342.343
Fa'asao: 212.9 ± 23.6 ° C
Misasa'o: 342.110352
PSA:85.22000
LogP:5.16
O'omiga ausa: 0.0 ± 1.7 mmHg ile 25°C
Fa'asino Upu: 1.654
Fa'aigoa Igilisi ole Methylophiopogonanone A
(1,3-Benzodioxol-5-ylmethyl) -5,7-dihydroxy-6,8-dimethyl-2,3-dihydro-4H-chromen-4-one
4H-1-Benzopyran-4-tasi, 3-(1,3-benzodioxol-5-ylmethyl) -2,3-dihydro-5,7-dihydroxy-6,8-dimethyl-
N1002
Methylophiopogonanone A
Auaunaga a Yongjian
Au'aunaga Fa'apitoa O Mea Fa'asinoala Vailaau Fa'asaienisi Fa'afomai Saina
Jiangsu Yongjian Pharmaceutical Technology Co., Ltd. o lo'o fa'atino tele i su'esu'ega fa'avae o vaila'au fa'aSaina masani mo le silia ma le sefulu tausaga.I le taimi nei, o loʻo faʻatautaia e le kamupani suʻesuʻega loloto i luga o le sili atu i le 100 ituaiga o vailaʻau faʻaSaina masani masani, ma maua mai le faitau afe o vaega vailaʻau.
O le kamupani o loʻo i ai tagata faigaluega R & D sili ma suʻega atoatoa ma auʻiliʻili meafaigaluega i totonu o le alamanuia, ma sa tautuaina le faitau selau o faʻalapotopotoga suʻesuʻe faasaienisi.E mafai ona vave ma fetaui lelei manaʻoga o tagata faʻatau
Tu'ueseeseina o Vailaau Fa'aleaga, Tapenaga ma Au'aunaga Fa'amautuga
O mea leaga i vailaʻau e fesoʻotaʻi vavalalata ma le lelei, saogalemu ma le mautu o vailaʻau.O le sauniuniga ma le faʻamautuina o le fausaga o mea le mama i vailaʻau e mafai ona fesoasoani ia i tatou ia malamalama i auala o le mama ma maua ai se faʻavae mo le faʻaleleia o le gaosiga o gaioiga.O le mea lea, o le sauniuniga ma le vavaeeseina o mea le mama e taua tele i suʻesuʻega ma atinaʻe vailaʻau.
Ae ui i lea, o mea o loʻo i totonu o le vailaʻau e maualalo, o le puna e lautele, ma o le fausaga e tele lava e tutusa ma le vaega autu.O le a le tekinolosi e mafai ona faʻaaogaina e vavae ese ai ma faʻamamā uma mea leaga i totonu o le vailaʻau taʻitasi ma vave?O a metotia ma metotia o loʻo faʻaaogaina e faʻamaonia ai le fausaga o nei mea leaga?O le faigata lea ma le luʻitau o loʻo feagai ma le tele o vailaʻau faʻapitoa, aemaise lava pisinisi faʻafomaʻi o vailaʻau o laau ma vailaʻau pateni Saina.
Faʻavae i luga o ia manaʻoga, ua faʻalauiloa e le kamupani le vavaeeseina o vailaʻau leaga ma le faʻamamaina o auaunaga.Faʻalagolago i le faʻamaneta faaniukilia resonance, tele spectrometry ma isi meafaigaluega ma tekinolosi, e mafai e le kamupani ona vave iloa le fausaga o le tuufaatasiga eseese, ina ia fetaui ma manaoga o tagata faatau.
SPF Fa'ata'ita'iga Manu
O le vaega fau o le nofoaga faataitai manu e 1500 sikuea mita, e aofia ai le 400 sikuea mita o le SPF tulaga faʻataʻitaʻiga nofoaga ma 100 sikuea mita o P2 tulaga suʻesuʻe sela.Ta'ita'ia e saienitisi a Saina Pharmaceutical University, o lo'o fausia ai se 'au fa'apitoa fa'apitoa ma le tele o tagata toe fo'i mai.Tuuina atu faʻataʻitaʻiga manu sili ona lelei, faʻataʻitaʻiga faʻataʻitaʻiga, galuega lautele ma isi auaunaga mo suʻesuʻega faʻasaienisi biomedical, aʻoaʻoga ma atinaʻe fale gaosi oloa.
Avanoa o Pisinisi
1. Fafaga manu laiti
2. Fa'ata'ita'iga fa'ama'i manu
3. Poloketi Kolisi outsourcing
4. Iloiloga Pharmacodynamic i vivo
5. Iloiloga Pharmacokinetic
6. Tumor cell su'esu'e auaunaga
O Tatou Malosi
1. Taulai atu i suʻega moni
2. Fa'ata'atia lelei le faiga
3. Saini maoti le maliega e le faalauaiteleina
4. Lava fale su'esu'e e aunoa ma so'otaga va'ava'ai
5. O le 'au faʻapitoa faʻapolofesa faʻamaonia le tulaga faʻataʻitaʻi
Si'osi'omaga fa'ata'ita'i SPF, fafaga fa'apitoa a le tagata, su'esu'e fa'ata'ita'i fa'ata'ita'iga
