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Methylophiopogonanone A;Opogonanone A

Tsanangudzo Pfupi

Common Name: Ophiopogon japonicus high isoflavone a

Shona Zita: methylophiopogonnone a

Nhamba yeCAS: 74805-92-8

Molecular uremu: 342.343

Density: 1.4 ± 0.1 g / cm3

Boiling Poindi: 580.1 ± 50.0 ° C pa760 mmHg

Molecular Formula: c19h18o6

Melting Point: N/ A

MSDS: N/ A

Flash Point: 212.9 ± 23.6 ° C


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Kushandiswa kweMethylophiopogonanone A

Methylophiopogonanone A is flavonoid yakatorwa muOphiopogon japonicas, ine antioxidant uye anti-inflammatory effects.

Zita reMethylophiopogonanone A

Chirungu Zita:
(3R)-3-(1,3-benzodioxol-5-ylmethyl)-5,7-dihydroxy-6,8-dimethyl-2,3-dihydrochromen-4-imwe

Chine zita reChinese:
Ophiopogon methyl flavanone a |methyl Ophiopogon dihydrohomoisoflavone a |methyl Ophiopogon flavanone a

Biological Chiitiko cheMethylophiopogonanone A

Tsanangudzo: methylophiopogonanone A is flavonoid yakatorwa kubva kuOphiopogon japonicas, ine
antioxidant uye anti-inflammatory effects.
Related Categories: chiratidzo nzira>> apoptosis>> apoptosis
research field > > kuzvimba / kusadzivirirwa

MuVitro Chidzidzo: methyl aspartate a (mo-a; 10 μ Mo (L / L) yakanyanya kuderera apoptosis uye Caspase-3 kutaura, yakawedzera Bcl-2 / Bax chiyero uye yakadzoreredza kugadzirwa. Methylaspartate a (mo-a) pretreatment.

yakawedzera zvakanyanya kushandiswa kwePI3K / Akt / eNOS nzira muH9c2 masero pasi peH / R, nepo kudzivirira kwe mo-a kwakabviswa pamberi pePI3K inhibitor wortmannin (100 nmol / L) [1].

MuVivo Chidzidzo: kudzivirira maitiro emethylaspartate a (mo-a; 10mg / kg / D, PO) pamwoyo webasa mushure mekukuvara kwemyocardial I / R [1].

Zvinyorwa: [1] He F, et al.Methylophiopogonanone A inodzvanya ischemia/reperfusion-induced myocardial apoptosis mumakonzo kuburikidza ne activating PI3K/Akt/eNOS signing nzira.Acta Pharmacol Chivi.2016 Jun;37(6):763-71.

Physicochemical zvimiro zveMethylophiopogonanone A

Density: 1.4 ± 0.1 g / cm3

Boiling Poindi: 580.1 ± 50.0 ° C pa760 mmHg

Molecular Formula: c19h18o6

Molecular uremu: 342.343

Flash Point: 212.9 ± 23.6 ° C

Chaiyo Misa: 342.110352

PSA:85.22000

LogP:5.16

Steam Pressure: 0.0 ± 1.7 mmHg pa25 ° C

Refractive Index: 1.654

Chirungu Alias ​​Of Methylophiopogonanone A

(1,3-Benzodioxol-5-ylmethyl)-5,7-dihydroxy-6,8-dimethyl-2,3-dihydro-4H-chromen-4-imwe

4H-1-Benzopyran-4-imwe, 3-(1,3-benzodioxol-5-ylmethyl)-2,3-dihydro-5,7-dihydroxy-6,8-dimethyl-

N1002

Methylophiopogonanone A

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4. Pharmacodynamic evaluation in vivo

5. Pharmacokinetic evaluation

6. Tumor cell experimental service

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