Methylophiopogonanone A;Opogonanone A
Codsiga Methylophiopogonanone A
Methylophiopogonanone A waa flavonoid laga soo saaro Ophiopogon japonicas, kaas oo leh saameyn antioxidant iyo anti-bararka.
Magaca Methylophiopogonanone A
Magaca Ingiriisiga:
(3R) -3- (1,3-benzodioxol-5-ylmethyl) -5,7-dihydroxy-6,8-dimethyl-2,3-dihydrochromen-4-hal
Magaca Shiinaha:
Ophiopogon methyl flavanone a |methyl Ophiopogon dihydrohomoisoflavone a |methyl Ophiopogon flavanone a
Waxqabadka Nafleyda ee Methylophiopogonanone A
Sharaxaad: methylophiopogonanone A waa flavonoid laga soo saaray Ophiopogon japonicas, kaas oo leh
antioxidant iyo saamaynta anti-bararka.
Qaybaha laxidhiidha: jidka calaamada > > apoptosis > > apoptosis
goobta cilmi-baarista > > caabuq / difaac
Daraasadda Vitro: methyl aspartate a (mo-a; 10 μ Mo (L / L) ayaa si weyn hoos ugu dhacay apoptosis iyo muujinta Caspase-3, waxay kordhisay saamiga Bcl-2 / Bax mana soo celin wax soo saar. Methylaspartate a (mo-a) pretreatment
Waxay si weyn u wanaajisay firfircoonida PI3K / Akt / eNOS ee unugyada H9c2 ee hoos yimaada H / R, halka saamaynta ilaalinta mo-a la joojiyay iyadoo ay jirto PI3K inhibitor wortmannin (100 nmol / L) [1].
Daraasadda Vivo: Saamaynta ilaalinta methylaspartate a (mo-a; 10mg / kg / D, PO) ee shaqada wadnaha ka dib dhaawaca myocardial I / R [1].
Tixraacyada: [1] He F, et al.Methylophiopogonanone A waxay xakameysaa ischemia/dib-u-celinta apoptosis myocardial apoptosis ee jiirarka iyada oo la dhaqaajinayo PI3K/Akt/eNOS dariiqa calaamadaynta.Acta Pharmacol Sin.2016 Juun;37 (6): 763-71.
Sifooyinka kiimikaad ee Methylophiopogonanone A
Cufnaanta: 1.4 ± 0.1 g / cm3
Barta karkarinta: 580.1 ± 50.0 ° C at 760 mmHg
Qaacidada molecular: c19h18o6
Miisaanka Molecular: 342.343
Barta Tooshka ah: 212.9 ± 23.6 ° C
Tirada saxda ah: 342.110352
PSA:85.22000
LogP:5.16
Cadaadiska Uumiga: 0.0 ± 1.7 mmHg at 25 ° C
Tusmada dib-u-celinta: 1.654
Magaca Ingiriisiga ee Methylophiopogonanone A
(1,3-Benzodioxol-5-ylmethyl)-5,7-dihydroxy-6,8-dimethyl-2,3-dihydro-4H-chromen-4-hal
4H-1-Benzopyran-4-kow, 3- (1,3-benzodioxol-5-ylmethyl) -2,3-dihydro-5,7-dihydroxy-6,8-dimethyl-
N1002
Methylophiopogonanone A
Adeegga Yongjian
Adeegga Habboon ee Qalabka Tixraaca Kiimikada ee Daawada Dhaqanka ee Shiinaha
Jiangsu Yongjian Pharmaceutical Technology Co., Ltd. ayaa inta badan ku hawlan cilmi-baarista aasaasiga ah ee walxaha firfircoon ee daawada dhaqameed ee Shiinaha in ka badan toban sano.Ilaa hadda, shirkaddu waxay cilmi-baadhis qoto-dheer ku samaysay in ka badan 100 nooc oo ah dawo-dhaqameedka Shiinaha ee inta badan la isticmaalo, waxaanay soo saartay kumannaan qaybood oo kiimiko ah.
Shirkaddu waxay leedahay shaqaale sare oo R & D ah iyo qalab tijaabo iyo falanqayn sax ah oo ku jira warshadaha, waxayna u adeegtay boqolaal machadyo cilmi baaris cilmiyeed.Waxay si dhakhso ah oo hufan u dabooli kartaa baahida macaamiisha
Kala-saar Xumo-xumo Daroogada, Diyaarinta iyo Adeegga Xaqiijinta Qaab-dhismeedka
Wasakhda daroogooyinka waxay si dhow ula xiriiraan tayada, badbaadada iyo xasiloonida daroogada.Xaqiijinta diyaarinta iyo qaab dhismeedka wasakhda daroogooyinka waxay naga caawin kartaa inaan fahamno hababka wasakhda iyo bixinta aasaaska hagaajinta habka wax soo saarka.Sidaa darteed, diyaarinta iyo kala-soocidda wasakhdu waxay muhiimad weyn u leedahay cilmi-baarista iyo horumarinta daroogada.
Si kastaba ha ahaatee, waxa ku jira wasakhda daawadu way yar tahay, isha waa ballaadhan tahay, qaab-dhismeedkuna inta badan wuxuu la mid yahay qaybta ugu muhiimsan.Tignoolajiyada noocee ah ayaa loo isticmaali karaa in lagu kala saaro oo lagu nadiifiyo dhammaan wasakhda daawada mid mid iyo si degdeg ah?Waa maxay farsamooyinka iyo hababka loo isticmaalo si loo xaqiijiyo dhismaha wasakhdaas?Tani waa dhibka iyo caqabada ay la kulmaan qaybo badan oo dawooyin ah, gaar ahaan shirkadaha dawooyinka ee dawooyinka dhirta iyo daawaynta patent-ka Shiinaha.
Iyada oo ku saleysan baahiyaha noocaas ah, shirkaddu waxay bilawday adeegyada kala soocida wasakhda iyo nadiifinta daroogada.Ku tiirsanaanta nukliyeerka magnetic nukliyeerka, spectrometry mass iyo qalabka kale iyo teknoolajiyada, shirkaddu waxay si dhakhso ah u aqoonsan kartaa qaab-dhismeedka xeryahooda kala go'ay, si loo daboolo baahiyaha macaamiisha.
Tijaabada Xayawaanka ee SPF
Bedka dhismaha ee goobta tijaabada xayawaanku waa 1500 mitir oo laba jibbaaran, oo ay ku jiraan 400 mitir oo laba jibbaaran oo aag tijaabo ah oo heerka SPF ah iyo 100 mitir oo laba jibbaaran oo ah shaybaadhka unugyada heerka P2.Oo ay hogaaminayaan saynisyahano ka tirsan Jaamacadda Pharmaceutical ee Shiinaha, waxay samaysaa koox farsamo oo xudun u ah tiro dad ah oo soo noqday.Bixi noocyo xayawaan oo tayo sare leh, naqshadeynta tijaabada, mashaariicda guud iyo adeegyada kale ee cilmi-baarista cilmiga noolaha, barida iyo horumarinta warshadaha.
Baaxadda Ganacsiga
1. quudinta xoolaha yar
2. Qaabaynta cudurada xoolaha
3. Dib-u-soo-saarka mashruuca kulliyadda
4. Qiimaynta Pharmacodynamic in vivo
5. Qiimaynta farmashiyaha
6. Adeegga tijaabada unugyada burada
Awoodeena
1. Diirada saar tijaabooyinka dhabta ah
2. Si adag u habeeyaan habka
3. Si adag u saxiix heshiiska sirta
4. Shaybaadh u gaar ah oo aan lahayn xiriiriye dhexdhexaad ah
5. Kooxda farsamada ee xirfadlayaasha ah ayaa dammaanad qaadaya tayada tijaabada ah
Deegaanka tijaabada SPF, quudinta qofka si gaar ah loo xilsaaray, la socodka wakhtiga dhabta ah ee horumarka tijaabada ah
