Methylophiopogonanone A;Opogonanone A
Ohun elo Methylophiopogonanone A
Methylophiopogonanone A jẹ flavonoid ti a fa jade lati Ophiopogon japonicas, eyiti o ni awọn ipadanu antioxidant ati awọn ipa-iredodo.
Orukọ Methylophiopogonanone A
Orukọ Gẹẹsi:
(3R) -3- (1,3-benzodioxol-5-ylmethyl) -5,7-dihydroxy-6,8-dimethyl-2,3-dihydrochromen-4-ọkan
Apejẹ Kannada:
Ophiopogon methyl flavanone a |methyl Ophiopogon dihydrohomoisoflavone a |methyl Ophiopogon flavanone a
Iṣẹ ṣiṣe ti ẹkọ ti Methylophiopogonanone A
Apejuwe: methylophiopogonanone A jẹ flavonoid ti a fa jade lati Ophiopogon japonica, eyiti o ni
antioxidant ati egboogi-iredodo ipa.
Awọn ẹka ti o jọmọ: ipa ọna ifihan agbara>> apoptosis>> apoptosis
aaye iwadi > > igbona / ajesara
Ninu Ikẹkọ Vitro: methyl aspartate a (mo-a; 10 μ Mo (L / L) dinku ni pataki apoptosis ati ikosile Caspase-3, pọsi Bcl-2 / Bax ratio ati mu pada ko si iṣelọpọ. Methylaspartate a (mo-a) pretreatment
ni ilọsiwaju imuṣiṣẹ ti PI3K / Akt / eNOS ipa ọna ni awọn sẹẹli H9c2 labẹ H / R, lakoko ti ipa aabo ti mo-a ti fagile ni iwaju PI3K inhibitor wortmannin (100 nmol / L) [1].
Ninu Ikẹkọ Vivo: ipa aabo ti methylaspartate a (mo-a; 10mg / kg / D, PO) lori iṣẹ ọkan ọkan lẹhin ipalara I / R myocardial [1].
Awọn itọkasi: [1] He F, et al.Methylophiopogonanone A n pa ischemia/apoptosis myocardial induced reperfusion ninu awọn eku nipasẹ ṣiṣiṣẹ PI3K/Akt/eNOS ipa ọna ifihan.Acta Pharmacol Ẹṣẹ.Ọdun 2016 Oṣu Kẹta;37 (6): 763-71.
Awọn ohun-ini Kemikali ti Methylophiopogonanone A
iwuwo: 1.4 ± 0.1 g / cm3
Ojuami Sise: 580.1 ± 50.0 ° C ni 760 mmHg
Ilana molikula: c19h18o6
Iwọn Molikula: 342.343
Ojuami Filasi: 212.9 ± 23.6 ° C
Gangan Ibi: 342.110352
PSA: 85.22000
LogP:5.16
Titẹ Nya si: 0.0 ± 1.7 mmHg ni 25 ° C
Atọka itọka: 1.654
Inagijẹ Gẹẹsi ti Methylophiopogonanone A
(1,3-Benzodioxol-5-ylmethyl) -5,7-dihydroxy-6,8-dimethyl-2,3-dihydro-4H-chromen-4-ọkan
4H-1-Benzopyran-4-ọkan, 3- (1,3-benzodioxol-5-ylmethyl) -2,3-dihydro-5,7-dihydroxy-6,8-dimethyl-
N1002
Methylophiopogonanone A
Yongjian Service
Iṣẹ Adani Ti Awọn Ohun elo Itọkasi Kemikali Ti Oogun Kannada Ibile
Jiangsu Yongjian Pharmaceutical Technology Co., Ltd jẹ pataki ni iwadii ipilẹ ti awọn nkan ti nṣiṣe lọwọ ti oogun Kannada ibile fun diẹ sii ju ọdun mẹwa lọ.Titi di isisiyi, ile-iṣẹ naa ti ṣe iwadii ijinle lori diẹ sii ju awọn oriṣi 100 ti oogun Kannada ibile ti a lo nigbagbogbo, ti o fa ẹgbẹẹgbẹrun awọn paati kemikali jade.
Ile-iṣẹ naa ni oṣiṣẹ R & D ti o ga julọ ati idanwo pipe ati ohun elo itupalẹ ni ile-iṣẹ naa, ati pe o ti ṣe iranṣẹ awọn ọgọọgọrun ti awọn ile-iṣẹ iwadii imọ-jinlẹ.O le ni kiakia ati daradara pade awọn aini ti awọn onibara
Iyapa Aimọ Oògùn, Igbaradi ati Iṣẹ Imudaniloju Igbekale
Awọn idoti ninu awọn oogun ni ibatan pẹkipẹki si didara, ailewu ati iduroṣinṣin ti awọn oogun.Igbaradi ati ìmúdájú igbekalẹ ti awọn idoti ninu awọn oogun le ṣe iranlọwọ fun wa lati loye awọn ọna ti awọn aimọ ati pese ipilẹ fun ilọsiwaju ti ilana iṣelọpọ.Nitorinaa, igbaradi ati ipinya ti awọn aimọ jẹ pataki pataki si iwadii oogun ati idagbasoke.
Bibẹẹkọ, akoonu ti awọn aimọ ninu oogun naa kere, orisun jẹ fife, ati pe eto naa jọra julọ si paati akọkọ.Imọ-ẹrọ wo ni a le lo lati yapa ati sọ di mimọ gbogbo awọn idoti ninu oogun naa ni ọkọọkan ati yarayara?Awọn imọ-ẹrọ ati awọn ọna wo ni a lo lati jẹrisi ilana ti awọn idoti wọnyi?Eyi ni iṣoro ati ipenija ti o dojuko nipasẹ ọpọlọpọ awọn ẹka elegbogi, paapaa awọn ile-iṣẹ elegbogi ti oogun ọgbin ati oogun itọsi Kannada.
Da lori iru awọn iwulo, ile-iṣẹ ti ṣe ifilọlẹ iyapa aimọ oogun ati awọn iṣẹ isọdọmọ.Ti o da lori isọdọtun oofa iparun, iwoye pupọ ati ohun elo miiran ati awọn imọ-ẹrọ, ile-iṣẹ le ṣe idanimọ ọna ti awọn agbo ogun ti o yapa, lati le ba awọn iwulo awọn alabara pade.
SPF Animal adanwo
Agbegbe ikole ti agbegbe esiperimenta ẹranko jẹ awọn mita onigun mẹrin 1500, pẹlu awọn mita onigun mẹrin 400 ti agbegbe idanwo ipele SPF ati awọn mita mita 100 ti yàrá ipele sẹẹli P2.Ti o ṣe itọsọna nipasẹ awọn onimọ-jinlẹ ti Ile-ẹkọ giga elegbogi China, o ṣe agbekalẹ ẹgbẹ imọ-ẹrọ mojuto pẹlu nọmba awọn ipadabọ.Pese awọn awoṣe ẹranko ti o ni agbara giga, apẹrẹ idanwo, awọn iṣẹ akanṣe gbogbogbo ati awọn iṣẹ miiran fun iwadii imọ-jinlẹ biomedical, ẹkọ ati idagbasoke ile-iṣẹ.
Dopin Of Business
1. Kekere eranko ono
2. Animal arun modeli
3. College ise agbese outsourcing
4. Pharmacodynamic igbelewọn ni vivo
5. Pharmacokinetic igbelewọn
6. Tumor cell ṣàdánwò iṣẹ
Awọn Agbara Wa
1. Fojusi lori awọn idanwo gidi
2. Muna standardize awọn ilana
3. Muna fowo si adehun asiri
4. Ti ara yàrá laisi awọn ọna asopọ agbedemeji
5. Awọn ọjọgbọn imọ egbe onigbọwọ awọn esiperimenta didara
Ayika esiperimenta SPF, ifunni eniyan pataki ti a sọtọ, ilọsiwaju esiperimenta ipasẹ akoko gidi
