Methylophiopogonanone A;Opogonanone A.
Gukoresha Methylophiopogonanone A.
Methylophiopogonanone A ni flavonoide yakuwe muri japonicas ya Ophiopogon, ifite antioxydeant na anti-inflammatory.
Izina rya Methylophiopogonanone A.
Izina ry'icyongereza:
(3R) -3-.
Abashinwa Alias:
Ophiopogon methyl flavanone a |methyl Ophiopogon dihydrohomoisoflavone a |methyl Ophiopogon flavanone a
Igikorwa cyibinyabuzima cya Methylophiopogonanone A.
Ibisobanuro: methylophiopogonanone A ni flavonoide yakuwe muri japonicas ya Ophiopogon, ifite
antioxydeant na anti-inflammatory ingaruka.
Ibyiciro bifitanye isano: inzira yinzira >> apoptose >> apoptose
umurima wubushakashatsi >> gutwika / ubudahangarwa
Mu bushakashatsi bwa Vitro: methyl aspartate a (mo-a; 10 μ Mo (L / L) yagabanutse cyane imvugo ya apoptose na Caspase-3, yongera igipimo cya Bcl-2 / Bax kandi ntigarura umusaruro. Methylaspartate a (mo-a) kwitegura.
yazamuye cyane ibikorwa bya PI3K / Akt / eNOS inzira muri selile H9c2 munsi ya H / R, mugihe ingaruka zo gukingira mo-a zahagaritswe imbere ya PI3K inhibitor wortmannin (100 nmol / L) [1].
Mu bushakashatsi bwa Vivo: ingaruka zo gukingira methylaspartate a (mo-a; 10mg / kg / D, PO) kumikorere yumutima nyuma yimvune ya myocardial I / R [1].
Reba: [1] We F, n'abandi.Methylophiopogonanone A irwanya ischemia / reperfusion-iterwa na myocardial apoptose mu mbeba ikoresheje PI3K / Akt / eNOS yerekana inzira.Acta Pharmacol Icyaha.2016 Jun;37 (6): 763-71.
Imiterere ya fiziki ya Himiki ya Methylophiopogonanone A.
Ubucucike: 1.4 ± 0.1 g / cm3
Ingingo yo guteka: 580.1 ± 50.0 ° C kuri 760 mmHg
Inzira ya molekulari: c19h18o6
Uburemere bwa molekuline: 342.343
Ingingo ya Flash: 212.9 ± 23,6 ° C.
Misa nyayo: 342.110352
PSA: 85.22000
LogP: 5.16
Umuvuduko wamazi: 0.0 ± 1,7 mmHg kuri 25 ° C.
Ironderero: 1.654
Icyongereza Alias Ya Methylophiopogonanone A.
(1,3-Benzodioxol-5-ylmethyl) -5,7-dihydroxy-6,8-dimethyl-2,3-dihydro-4H-chromen-4-imwe
4H-1-Benzopyran-4-imwe, 3- (1,3-benzodioxol-5-ylmethyl) -2,3-dihydro-5,7-dihydroxy-6,8-dimethyl-
N1002
Methylophiopogonanone A.
Yongjian Service
Serivisi yihariye Yibikoresho Byifashishwa mubuvuzi gakondo bwabashinwa
Jiangsu Yongjian Pharmaceutical Technology Co., Ltd akora cyane cyane mubushakashatsi bwibanze bwibintu bikora byubuvuzi gakondo bwabashinwa mumyaka irenga icumi.Kugeza ubu, isosiyete imaze gukora ubushakashatsi bwimbitse ku bwoko burenga 100 bw’imiti gakondo ikoreshwa mu Bushinwa, kandi ikuramo ibihumbi n’ibigize imiti.
Isosiyete ifite abakozi bakuru ba R & D nibikoresho byiza byo gupima no gusesengura mu nganda, kandi imaze gukorera ibigo byubushakashatsi amagana.Irashobora kwihuta kandi neza ibyifuzo byabakiriya
Gutandukanya Ibiyobyabwenge, Gutegura no Kwemeza Serivisi
Umwanda mubi biyobyabwenge bifitanye isano rya bugufi nubwiza, umutekano n’umutekano w’ibiyobyabwenge.Gutegura no kwemeza imiterere yanduye mu biyobyabwenge birashobora kudufasha kumva inzira zanduye kandi bigatanga umusingi wo kunoza imikorere.Kubwibyo, gutegura no gutandukanya umwanda bifite akamaro kanini mubushakashatsi bwibiyobyabwenge niterambere.
Nyamara, ibirimo umwanda uri mu biyobyabwenge ni bike, isoko ni nini, kandi imiterere isa cyane ningenzi.Ni ubuhe buryo bw'ikoranabuhanga bwakoreshwa mu gutandukanya no kweza umwanda wose uri mu biyobyabwenge umwe umwe kandi vuba?Ni ubuhe buryo n'uburyo bukoreshwa mu kwemeza imiterere y'iyi myanda?Ngiyo ingorane ningorabahizi byugarije imiti myinshi yimiti, cyane cyane imishinga yimiti yubuvuzi bwibimera nubuvuzi bwa patenti mubushinwa.
Hashingiwe kubyo bikenewe, isosiyete yatangije serivisi zo gutandukanya no kwanduza ibiyobyabwenge.Isosiyete ishingiye kuri magnetiki resonance, mass spectrometrie nibindi bikoresho na tekinoroji, isosiyete irashobora kumenya byihuse imiterere yibintu bitandukanijwe, kugirango ibone ibyo abakiriya bakeneye.
Ubushakashatsi bw'inyamaswa
Ubuso bwubatswe bwahantu ho kugerageza inyamaswa ni metero kare 1500, harimo metero kare 400 zubushakashatsi bwa SPF kurwego na metero kare 100 za laboratoire ya P2.Iyobowe nabahanga bo muri kaminuza yimiti yubushinwa, ikora itsinda ryibanze rya tekinike hamwe nabatahutse.Tanga icyitegererezo cyiza cyinyamanswa, igishushanyo mbonera, imishinga rusange nizindi serivisi zubushakashatsi bwa siyanse yubumenyi bwibinyabuzima, kwigisha no guteza imbere inganda.
Umubare w'ubucuruzi
1. Kugaburira amatungo mato
2. Kwerekana indwara zinyamaswa
3. Gutanga umushinga wa kaminuza
4. Isuzuma rya farumasi muri vivo
5. Isuzuma rya farumasi
6. Serivisi yo kugerageza selile
Imbaraga zacu
1. Wibande ku bushakashatsi nyabwo
2. Kuringaniza byimazeyo inzira
3. Shyira umukono kumasezerano yibanga
4. Laboratoire yawe idafite aho ihurira
5. Itsinda rya tekinike yabigize umwuga ryemeza ubuziranenge bwubushakashatsi
SPF ibidukikije byubushakashatsi, byagenwe byabantu kugaburira, igihe-gikurikirana iterambere ryikigereranyo
