Neohesperidin
Aikace-aikacen Synephrine Hydrochloride
Neohesperidin wani nau'i ne na fili na flavonoid wanda ya wanzu a cikin tsire-tsire na Cucurbitaceae kuma yana da tasirin antioxidant da anti-inflammatory./h2>
Sunan mahaifi Neohesperidin
Sunan Ingilishi: neohesperidin
Laƙabin Sinanci: neohesperidin |neohesperidin
Bioactivity na Neohesperidin
Bayani: neohesperidin wani fili ne na flavonoid da aka samu a cikin Cucurbitaceae, wanda ke da tasirin antioxidant da anti-mai kumburi.
Rukunin masu alaƙa: Hanyar sigina > > wasu > > wani
filin bincike > > kumburi / rigakafi
na halitta Products > > flavonoids
A cikin Nazarin Vitro:
Sabon hesperidin yana haifar da apoptosis a cikin ciwon nono na mutum MDA-MB-231 Kwayoyin.Ma'auni na IC50 na neohesperidin a 24 da 48 hours sun kasance 47.4 ± 2.6, bi da bi μ M da 32.5 ± 1.8 μ M. Maganar p53 da Bax sun kasance da mahimmanci a cikin kwayoyin neohesperidin da aka bi da su, yayin da bayyanar Bcl-2 ya ragu. tsari [1].Neohesperidin ya nuna aikin antioxidant a cikin DPPH radical scavenging gwajin (IC50 = 22.31 μ g / ml) [2].
A cikin Nazarin Vivo: Neohesperidin (50mg / kg) ya hana 55.0% HCl / ethanol da ke haifar da rauni na ciki.A cikin berayen pylorus ligated, neohesperidin (50 MG / kg) ya rage yawan fitowar ciki da fitowar acid na ciki da haɓaka pH [1].Maganin Neohesperidin ya rage yawan glucose na jini na azumi, glucose na jini da furotin glycosylated serum (GSP) a cikin mice.Ya ƙara haɓaka juriya na glucose na baki da haɓakar insulin, da rage juriya na insulin a cikin berayen masu ciwon sukari.Neohesperidin ya rage mahimmancin maganin triglycerides, jimlar cholesterol, matakan leptin da hanta a cikin mice [3].
Gwajin Dabbobi: beraye: Dukan beraye sun yi azumin sa'o'i 6 kafin gwajin, sannan an ciyar da su da ruwa ko neohesperidin ta hanyar ciyar da tilas.Don OGTT da ITT, an yi wa berayen allura ta ciki tare da 2G / kg BW glucose ko insulin 1iu / kg BW, bi da bi.An tattara samfuran jini daga jijiyar caudal don auna matakan glucose na jini na basal (minti 0) kafin allurar glucose ko insulin.An auna ƙarin matakan glucose na jini a minti 30, 60, 90 da 120 [3].
Magana:[1].Lee JH, et al.Abubuwan kariya na neohesperidin da poncirin keɓe daga 'ya'yan Poncirus trifoliata akan yuwuwar cututtukan ciki.Phytother Res.2009 Dec; 23 (12): 1748-53.
[2].Xu F, et al.Neohesperidin yana haifar da apoptosis na salula a cikin nono adenocarcinoma na mutum MDA-MB-231 Kwayoyin ta hanyar kunna hanyar siginar Bcl-2/Bax.Nat Prod Commun.2012 Nuwamba; 7 (11): 1475-8.
[3].Jia S, et al.Hypoglycemic da hypolipidemic sakamako na neohesperidin da aka samu daga Citrus aurantium L. a cikin ciwon sukari KK-A (y) mice.Ayyukan Abinci.2015 Maris; 6 (3): 878-86.
Abubuwan Halitta na Physicochemical Na Neohesperidin
Girma: 1.7 ± 0.1 g / cm3
Tushen tafasa: 933.7 ± 65.0 ° C a 760 mmHg
Lokacin narkewa: 239-243 º C
Tsarin kwayoyin halitta: C28H34O15
Nauyin Kwayoyin: 610.561
Wutar Wuta: 306.7 ± 27.8 ° C
Daidai Mass: 610.189758
Saukewa: 234.29000
Shafin: 2.44
Bayyanar: 0.0 ± 0.3 mmHg a 25 ° C
Matsin lamba: 0.0 ± 0.3 mmHg a 25 ° C
Fihirisar Magana: 1.695
Yanayin Ajiya: 2-8 ° C
Sabon Bayanin Tsaro na Hesperidin
Kayayyakin kariya na sirri: gashin ido;safar hannu;nau'in N95 (US);nau'in P1 (EN143) tace mai numfashi
Bayanin Tsaro (Turai): s22-s24 / 25
Lambar sufuri na kaya masu haɗari: nonh don duk hanyoyin sufuri
Jamus: 3
Lambar RTECS: dj2981400
Adabin Neohesperidin
Kwatanta na rayuwa da nazarin kwafi na diploid ninki biyu da diploid citrus rootstock (C. junos cv. Ziyang xiangcheng) yana nuna yuwuwar darajarsa don inganta juriya.
BMC Plant Biol.15, 89, (2015)
An yi la'akari da polyploidy sau da yawa don ba da tsire-tsire mafi dacewa ga matsalolin muhalli.Tetraploid citrus rootstocks ana sa ran samun ƙarfin jurewar damuwa fiye da diploid.Yawaitar...
Ougan (Citrus reticulata cv. Suavissima) flavedo tsantsa ya hana ciwon daji motsi ta hanyar tsoma baki tare da epithelial-to-mesenchymal miƙa mulki a cikin SKOV3 Kwayoyin.
ChinMed.10, 14, (2015)
Ougan (Citrus reticulata cv. Suavissima) flavedo tsantsa (OFE) ya nuna yuwuwar tasirin rigakafin ciwon daji tare da ingantattun hanyoyin da ba a sani ba.Wannan binciken yana nufin kimanta yiwuwar anti-metastatic acti ...
Hesperidin, nobiletin, da tangeretin suna da alhakin gaba ɗaya don ƙarfin anti-neuroinflammatory na kwasfa tangerine (Citri reticulatae pericarpium).
Chem abinci.Toxicol.71, 176-82, (2014)
Hana ƙaddamar da ƙwayar cuta ta microglial-matsakaici neuroinflammation ya zama manufa mai gamsarwa don haɓaka abinci mai aiki don magance cututtukan neurodegenerative.Bawon Tangerine (Citri reticulata...
Sunan Ingilishi na Neohesperidin
HESPERETIN-7-NEOHESPERIDOSIDE
Hesperetin7-neohesperidoside
4H-1-Benzopyran-4-daya, 7-[2-O- (6-deoxy-α-L-mannopyranosyl) -β-D-glucopyranosyl] -2,3-dihydro-5-hydroxy-2 (3-hydroxy-4-methoxyphenyl) -, (2S)
(2S) -5-Hydroxy-2- (3-hydroxy-4-methoxyphenyl) -4-oxo-3,4-dihydro-2H-chromen-7-yl 2-O- (6-deoxy-α-L- mannopyranosyl) β-D-glucopyranoside
hesperetin 7-O-neohesperoside
Neohesperdin
Neohesperdin
Saukewa: MFCD00017357
Hesperetin-7-O-neohesperidoside
EINECS 236-216-9
(S) -4'-Methoxy-3',5,7-trihydroxyflavanone-7-[2-O- (α-L-rhamnopyranosyl) -β-D-glucopyranoside]
4H-1-Benzopyran-4-daya, 2,3-dihydro-7-(2-O- (6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl) oxy) -5-hydroxy-2 -(3-hydroxy-4-methoxyphenyl)-, (S)
Hesperetin 7-O-neohesperidoside
