I-Neohesperidin
Ukusetshenziswa kwe-Synephrine Hydrochloride
I-Neohesperidin iwuhlobo lwenhlanganisela ye-flavonoid etholakala kabanzi ezitshalweni ze-Cucurbitaceae futhi inemiphumela elwa nokuvuvukala kanye ne-anti-inflammatory./h2>
Igama le-Neohesperidin
Igama lesiNgisi: neohesperidin
Isibizo sesiShayina: neohesperidin |neohesperidin
I-Bioactivity ye-Neohesperidin
Incazelo: i-neohesperidin iyinhlanganisela ye-flavonoid etholakala ku-Cucurbitaceae, ene-antioxidant ne-anti-inflammatory effects.
Izigaba ezihlobene: indlela yesiginali > > okunye > > okunye
inkundla yocwaningo > > ukuvuvukala / ukungatheleleki
imikhiqizo yemvelo > > flavonoids
Isifundo se-In Vitro:
I-hesperidin entsha yenza i-apoptosis kumdlavuza webele womuntu we-MDA-MB-231 amaseli.Amanani e-IC50 e-neohesperidin ku-24 namahora angu-48 ayengu-47.4 ± 2.6, ngokulandelana μ M kanye no-32.5 ± 1.8 μ M. Ukuvezwa kwe-p53 ne-Bax kwakumiswe phezulu kakhulu kumaseli aphathwe neohesperidin, kuyilapho ukubonakaliswa kwe-Bcl-2 kwakuphansi. kulawulwa [1].I-Neohesperidin ibonise umsebenzi we-antioxidant ekuhlolweni kwe-DPPH okuqothulayo (IC50 = 22.31 μ g/ mL) [2].
Esifundweni se-Vivo: i-neohesperidin (50mg / kg) ivimbele kakhulu i-55.0% ye-HCl / i-ethanol ebangele ukulimala kwesisu.Kumagundane ane-pylorus ligated, i-neohesperidin (50 mg / kg) inciphise kakhulu ukukhishwa kwesisu kanye nokukhishwa kwe-asidi yesisu kanye nokwanda kwe-pH [1].Ukwelashwa kwe-Neohesperidin kwehlise kakhulu i-blood glucose esheshayo, i-blood glucose kanye ne-glycosylated serum protein (GSP) kumagundane.Yandisa kakhulu ukubekezelelwa kweglucose yomlomo kanye nokuzwela kwe-insulin, futhi yanciphisa ukumelana ne-insulin kumagundane anesifo sikashukela.I-Neohesperidin inciphise kakhulu i-serum triglycerides, i-cholesterol ephelele, amazinga e-leptin kanye nenkomba yesibindi kumagundane [3].
Ukuhlolwa Kwezilwane: Amagundane: Wonke amagundane azila ukudla amahora angu-6 ngaphambi kokuhlolwa, bese ephakelwa ngamanzi noma nge-neohesperidin ngokuphakelwa ngenkani.Ku-OGTT ne-ITT, amagundane ajovwa nge-intraperitoneally nge-glucose engu-2G / kg BW noma i-1iu / kg BW insulin, ngokulandelana.Amasampula egazi aqoqwa emthanjeni we-caudal ukukala amazinga eglucose e-basal (imizuzu engu-0) ngaphambi kokujova i-glucose noma i-insulin.Izinga le-glucose engeziwe likalwa ku-30, 60, 90 kanye nemizuzu engu-120 [3].
Inkomba:[1].U-Lee JH, et al.Imiphumela yokuzivikela ye-neohesperidin ne-poncirin ehlukanisiwe nezithelo ze-Poncirus trifoliata ngesifo esingase sibe khona esiswini.I-Phytother Res.2009 Dec;23(12):1748-53.
[2].Xu F, et al.I-Neohesperidin yenza i-apoptosis yeselula kumaseli womuntu we-adenocarcinoma MDA-MB-231 ngokwenza kusebenze indlela yokusayina ye-Bcl-2/Bax-mediated.I-Nat Prod Commun.2012 Nov;7(11):1475-8.
[3].Jia S, et al.Imiphumela ye-Hypoglycemic kanye ne-hypolipidemic ye-neohesperidin etholakala ku-Citrus aurantium L. kumagundane e-KK-A(y) yesifo sikashukela.Umsebenzi Wokudla.2015 Mar;6(3):878-86.
Izakhiwo Ze-Physicochemical Of Neohesperidin
Ukuminyana: 1.7 ± 0.1 g / cm3
Indawo yokubilisa: 933.7 ± 65.0 ° C ku-760 mmHg
Indawo Encibilikayo: 239-243 º C
I-Molecular Formula: C28H34O15
Isisindo se-molecule: 610.561
I-Flash Point: 306.7 ± 27.8 ° C
IMisa ngqo: 610.189758
I-PSA: 234.29000
I-logP:2.44
Ukubukeka: 0.0 ± 0.3 mmHg ku-25 ° C
I-Steam Pressure: 0.0 ± 0.3 mmHg ku-25 ° C
Inkomba ye-Refractive: 1.695
Izimo Zokugcina: 2-8 ° C
Ulwazi Olusha Lokuphepha lwe-Hesperidin
Izinto zokuzivikela: izihlangu zamehlo;Amagilavu;uhlobo lwe-N95 (US);uhlobo P1 (EN143) isihlungi sokuphefumula
Isitatimende Sokuphepha (Europe): s22-s24 / 25
Ikhodi yokuthutha yezimpahla eziyingozi: i-nonh yazo zonke izindlela zokuthutha
I-Wgk Germany: 3
Inombolo ye-RTECS: dj2981400
Neohesperidin Literature
Ukuhlaziya okuqhathaniswayo kwe-metabolic kanye nokubhala phansi kwe-diploid ephindwe kabili kanye ne-diploid citrus rootstock (C. junos cv. Ziyang xiangcheng) kuphakamisa inani layo elingaba khona lokuthuthukisa ukumelana nokucindezeleka.
I-BMC Plant Biol.15, 89, (2015)
I-Polyploidy ivame ukubhekwa njengenikeza izitshalo ukuzivumelanisa kangcono nezingcindezi zemvelo.I-Tetraploid citrus rootstocks kulindeleke ukuthi ibe nokubekezelela ukucindezeleka okunamandla kune-diploid.Okunungi kwe...
I-Ougan (Citrus reticulata cv. Suavissima) i-flavedo ekhishwe icindezela ukuhamba komdlavuza ngokuphazamisa uguquko lwe-epithelial-to-mesenchymal kumaseli e-SKOV3.
Isilevu.Med.10, 14, (2015)
I-Ougan (Citrus reticulata cv. Suavissima) i-flavedo extract (OFE) ibonise imiphumela engaba khona yokulwa nesimila ngezindlela ezingacacile eziyisisekelo.Lolu cwaningo luhlose ukuhlola amandla e-anti-metastatic acti...
I-Hesperidin, i-nobiletin, ne-tangeretin ngokuhlangene yibo ababhekele amandla e-anti-neuroinflammatory wekhasi le-tangerine (Citri reticulatae pericarpium).
Ukudla Chem.I-Toxicol.71 , 176-82, (2014)
Ukuvimbela ukuvuvukala kwe-microglial activation-mediated neuroinflammation sekube yithagethi ekholisayo yokuthuthukiswa kokudla okusebenzayo ukwelapha izifo ze-neurodegenerative.Ikhasi leTangerine (Citri reticulata...
I-Alias yesiNgisi ye-Neohesperidin
I-HESPERETIN-7-NEOHESPERIDOSIDE
I-Hesperetin7-neohesperidoside
4H-1-Benzopyran-4-one, 7-[[2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy] -2,3-dihydro-5-hydroxy-2 -(3-hydroxy-4-methoxyphenyl)-, (2S)-
(2S)-5-Hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-oxo-3,4-dihydro-2H-chromen-7-yl 2-O-(6-deoxy-α-L- mannopyranosyl) -β-D-glucopyranoside
i-hesperetin 7-O-neohesperoside
I-Neohesperdin
I-Neohesperdin
I-MFCD00017357
I-Hesperetin-7-O-neohesperidoside
I-EINECS 236-216-9
(S) -4'-Methoxy-3',5,7-trihydroxyflavanone-7-[2-O-(α-L-rhamnopyranosyl)-β-D-glucopyranoside]
4H-1-Benzopyran-4-one, 2,3-dihydro-7-((2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl)oxy)-5-hydroxy-2 -(3-hydroxy-4-methoxyphenyl)-, (S)-
I-Hesperetin 7-O-neohesperidoside
