Neohesperidin
Ukusetyenziswa kwe-Synephrine Hydrochloride
I-Neohesperidin luhlobo lwekhompawundi ye-flavonoid ekhoyo ngokubanzi kwizityalo ze-Cucurbitaceae kwaye ineempembelelo ze-antioxidant kunye ne-anti-inflammatory./h2>
Igama le-Neohesperidin
Igama lesiNgesi: neohesperidin
Isi-Chinese Alias: neohesperidin |neohesperidin
I-Bioactivity ye-Neohesperidin
Inkcazo: i-neohesperidin i-compound ye-flavonoid efumaneka kwi-Cucurbitaceae, ene-antioxidant kunye ne-anti-inflammatory effects.
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inkalo yophando > > ukudumba / ukunganyangeki
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Isifundo se-In Vitro:
I-hesperidin entsha yenza i-apoptosis kumhlaza webele lomntu we-MDA-MB-231 iiseli.Iimpawu ze-IC50 ze-neohesperidin kwii-24 kunye neeyure ze-48 zaziyi-47.4 ± 2.6, ngokulandelanayo μ M kunye ne-32.5 ± 1.8 μ M. Ukubonakaliswa kwe-p53 kunye ne-Bax yayilawulwa kakhulu kwiiseli eziphathwayo ze-neohesperidin, ngelixa ukubonakaliswa kwe-Bcl-2 kwakuhla. ilawulwa [1].I-Neohesperidin ibonise umsebenzi wokulwa ne-antioxidant kwi-DPPH yokuvavanya ngokukrakra (IC50 = 22.31 μ g / mL) [2].
KwiSifundo seVivo: i-neohesperidin (50mg / kg) inqande kakhulu i-55.0% HCl / i-ethanol eyenza ukulimala kwesisu.Kwi-pylorus ligated rats, i-neohesperidin (50 mg / kg) yanciphisa kakhulu i-gastric secretion kunye ne-gastric acid output kunye nokunyuka kwe-pH [1].Unyango lwe-Neohesperidin luye lwanciphisa kakhulu i-glucose yegazi ngokukhawuleza, i-glucose yegazi kunye ne-glycosylated serum protein (GSP) kwiigundane.Yandisa kakhulu ukunyamezela kwe-glucose yomlomo kunye novelwano lwe-insulin, kunye nokunciphisa ukunganyangeki kwe-insulin kwiigundane zesifo seswekile.I-Neohesperidin yanciphisa kakhulu i-serum triglycerides, i-cholesterol epheleleyo, amanqanaba e-leptin kunye nesalathisi sesibindi kwiigundane [3].
Uvavanyo lwezilwanyana: iigundane: Zonke iigundane zizila ukutya kwiiyure ze-6 ngaphambi kovavanyo, kwaye emva koko zondliwa ngamanzi okanye i-neohesperidin ngokutya okunyanzeliswayo.Kwi-OGTT kunye ne-ITT, iigundane zafakwa kwi-intraperitoneally nge-2G / kg ye-BW glucose okanye i-1iu / kg ye-insulin ye-BW, ngokulandelanayo.Iisampulu zegazi ziqokelelwe kwi-caudal vein ukulinganisa amanqanaba e-basal glucose yegazi (imizuzu eyi-0) ngaphambi kokuba i-injection ye-glucose okanye i-insulin.Amanqanaba ongezelelweyo e-glucose yegazi alinganiswa kwi-30, i-60, i-90 kunye ne-120 imizuzu [3].
Imbekiselo:[1].U-Lee JH, kunye no-al.Iimpembelelo ezikhuselayo ze-neohesperidin kunye ne-poncirin eyedwa kwiziqhamo zePoncirus trifoliata kwisifo esinokwenzeka sesisu.Phytother Res.2009 Dec;23(12):1748-53.
[2].Xu F, kunye nabanye.I-Neohesperidin yenza i-apoptosis yeselula kwi-adenocarcinoma yebele yomntu i-MDA-MB-231 iiseli ngokusebenzisa i-Bcl-2/Bax-mediated signaling pathway.Nat Prod Commun.2012 Nov;7(11):1475-8.
[3].Jia S, et al.Imiphumo ye-Hypoglycemic kunye ne-hypolipidemic ye-neohesperidin ephuma kwi-Citrus aurantium L. kwi-diabetic KK-A (y) iigundane.Ukutya okusebenzayo.2015 Mar;6(3):878-86.
IiPropati zePhysicochemical of Neohesperidin
Ubuninzi: 1.7 ± 0.1 g / cm3
Indawo yokuBilisa: 933.7 ± 65.0 ° C kwi-760 mmHg
Indawo yokunyibilika: 239-243 º C
Ifomula yemolekyuli: C28H34O15
Ubunzima beMolekyuli: 610.561
Indawo edanyazayo: 306.7 ± 27.8 ° C
Ubunzima obuchanekileyo: 610.189758
PSA:234.29000
IlogP:2.44
Imbonakalo: 0.0 ± 0.3 mmHg kwi-25 ° C
Uxinzelelo lomphunga: 0.0 ± 0.3 mmHg ku-25 ° C
I-Refractive Index: 1.695
Iimeko zokuGcina: 2-8 ° C
Ulwazi olutsha loKhuseleko lwe-Hesperidin
Izixhobo zokuzikhusela: iikhaphethi zamehlo;Iiglavu;uhlobo lwe-N95 (US);uhlobo P1 (EN143) isihluzi sokuphefumla
Ingxelo yoKhuseleko (iYurophu): s22-s24 / 25
Ikhowudi yezothutho yempahla eyingozi: nonh kuzo zonke iindlela zothutho
Wgk eJamani: 3
Inombolo ye-RTECS: dj2981400
Neohesperidin Literature
Uhlalutyo oluthelekisayo lwemetabolism kunye nokubhaliweyo kwediploid ephindwe kabini kunye ne-diploid citrus rootstock (C. junos cv. Ziyang xiangcheng) icebisa ixabiso layo elinokubakho lokuphucula ukuxhathisa uxinzelelo.
I-BMC Plant Biol.15 , 89, (2015)
I-Polyploidy isoloko ithathwa njengenika izityalo ukulungelelaniswa okungcono kuxinzelelo lokusingqongileyo.I-Tetraploid citrus rootstocks kulindeleke ukuba ibe nokunyamezela koxinzelelo olunamandla kune-diploid.Okuninzi kwe...
I-Ougan (i-Citrus reticulata cv. Suavissima) isicatshulwa se-flavedo sicinezela i-motility yomhlaza ngokuphazamisa utshintsho lwe-epithelial-to-mesenchymal kwiiseli ze-SKOV3.
Isilevu.Med.10, 14, (2015)
I-Ougan (i-Citrus reticulata cv. Suavissima) isicatshulwa se-flavedo (OFE) ibonise iziphumo ezinokuthi zichase i-tumor kunye neendlela ezingacacanga ezingaphantsi.Olu phononongo lujolise ekuvavanyeni i-anti-metastatic acti enokubakho...
I-Hesperidin, i-nobiletin, kunye ne-tangeretin ngokudibeneyo inoxanduva lokulwa ne-neuroinflammatory umthamo we-tangerine peel (Citri reticulatae pericarpium).
Ukutya Chem.Ityhefu.71 , 176-82, (2014)
Ukuthintela i-microglial activation-mediated neuroinflammation iye yaba yinto ekujoliswe kuyo ekuphuhlisweni kokutya okusebenzayo ukunyanga izifo ze-neurodeergenerative.Amaxolo eTangerine (Citri reticulata...
Igama lesiNgesi likaNeohesperidin
I-HESPERETIN-7-NEOHESPERIDOSIDE
Hesperetin7-neohesperidoside
4H-1-Benzopyran-4-enye, 7-[[2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy] -2,3-dihydro-5-hydroxy-2 -(3-hydroxy-4-methoxyphenyl)-, (2S)-
(2S)-5-Hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-oxo-3,4-dihydro-2H-chromen-7-yl 2-O-(6-deoxy-α-L- mannopyranosyl)-β-D-glucopyranoside
hesperetin 7-O-neohesperoside
Neohesperdin
Neohesperdin
MFCD00017357
IHesperetin-7-O-neohesperidoside
I-EINECS 236-216-9
(S) -4'-Methoxy-3',5,7-trihydroxyflavanone-7-[2-O-(α-L-rhamnopyranosyl)-β-D-glucopyranoside]
4H-1-Benzopyran-4-enye, 2,3-dihydro-7- ((2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl) oxy) -5-hydroxy-2 -(3-hydroxy-4-methoxyphenyl)-, (S)-
Hesperetin 7-O-neohesperidoside
