Neohesperidin
Kugwiritsa ntchito Synephrine Hydrochloride
Neohesperidin ndi mtundu wa flavonoid pawiri womwe umapezeka kwambiri muzomera za Cucurbitaceae ndipo uli ndi antioxidant ndi anti-inflammatory effects./h2>
Dzina la Neohesperidin
Dzina la Chingerezi: neohesperidin
Dzina lachi China: neohesperidin |neohesperidin
Bioactivity ya Neohesperidin
Kufotokozera: neohesperidin ndi flavonoid pawiri yomwe imapezeka mu Cucurbitaceae, yomwe ili ndi antioxidant ndi anti-inflammatory effects.
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Phunziro la In Vitro:
Hesperidin yatsopano imapangitsa apoptosis mu khansa ya m'mawere ya anthu MDA-MB-231 maselo.Makhalidwe a IC50 a neohesperidin pa 24 ndi maola 48 anali 47.4 ± 2.6, motsatira μ M ndi 32.5 ± 1.8 μ M. Mafotokozedwe a p53 ndi Bax anali ovomerezeka kwambiri m'maselo opangidwa ndi neohesperidin, pamene mawu a Bcl-2 anali pansi. oyendetsedwa [1].Neohesperidin inawonetsa ntchito ya antioxidant mu DPPH kuyesa kwakukulu kowononga (IC50 = 22.31 μ g/ mL) [2].
Phunziro la Vivo: neohesperidin (50mg / kg) inaletsa kwambiri 55.0% HCl / ethanol inachititsa kuvulala kwa m'mimba.Mu pylorus ligated makoswe, neohesperidin (50 mg / kg) amachepetsa kwambiri katulutsidwe ka m'mimba ndi m'mimba acid komanso kuchuluka kwa pH [1].Chithandizo cha Neohesperidin chinachepetsa kwambiri kusala shuga wamagazi, shuga wamagazi ndi glycosylated serum protein (GSP) mu mbewa.Zimawonjezera kwambiri kulolerana kwa shuga m'kamwa komanso kumva kwa insulin, ndikuchepetsa kukana kwa insulin mu mbewa za matenda ashuga.Neohesperidin idachepetsa kwambiri seramu triglycerides, cholesterol yonse, milingo ya leptin ndi index ya chiwindi mu mbewa [3].
Kuyesa kwa Zinyama: Mbewa: Makoswe onse amasala maola 6 asanayesedwe, ndiyeno amadyetsedwa ndi madzi kapena neohesperidin mwa kudyetsa mokakamiza.Kwa OGTT ndi ITT, mbewa zidabayidwa intraperitoneally ndi 2G / kg BW shuga kapena 1iu / kg BW insulin, motsatana.Zitsanzo zamagazi zidasonkhanitsidwa kuchokera mumtsempha wa caudal kuti ayeze kuchuluka kwa shuga m'magazi (mphindi 0) asanabadwe shuga kapena insulin.Miyezo yowonjezera ya shuga m'magazi idayesedwa pa 30, 60, 90 ndi 120 mphindi [3].
Buku:[1].Lee JH, et al.Chitetezo cha neohesperidin ndi poncirin chosiyana ndi zipatso za Poncirus trifoliata pa matenda omwe angakhale a m'mimba.Phytother Res.2009 Dec;23(12):1748-53.
[2].Xu F, ndi al.Neohesperidin imapangitsa ma apoptosis a cell m'mawere a munthu adenocarcinoma MDA-MB-231 maselo kudzera poyambitsa njira yowonetsera ya Bcl-2/Bax-mediated.Nat Prod Commun.2012 Nov;7(11):1475-8.
[3].Jia S, ndi al.Hypoglycemic and hypolipidemic zotsatira za neohesperidin zotengedwa ku Citrus aurantium L. mu matenda a shuga a KK-A (y) mbewa.Ntchito Yakudya.2015 Marichi 6(3):878-86.
Physicochemical katundu wa Neohesperidin
Kachulukidwe: 1.7 ± 0.1 g / cm3
Malo Owira: 933.7 ± 65.0 ° C pa 760 mmHg
Malo osungunuka: 239-243 º C
Molecular Formula: C28H34O15
Kulemera kwa mamolekyu: 610.561
Flash Point: 306.7 ± 27.8 ° C
Kulemera kwake: 610.189758
PSA: 234.29000
Chizindikiro: 2.44
Maonekedwe: 0.0 ± 0.3 mmHg pa 25 ° C
Kuthamanga kwa Steam: 0.0 ± 0.3 mmHg pa 25 ° C
Refractive Index: 1.695
Zosungirako: 2-8 ° C
Zatsopano Zachitetezo cha Hesperidin
Zida zodzitetezera: zotchingira maso;Magolovesi;mtundu wa N95 (US);lembani P1 (EN143) fyuluta yopumira
Chidziwitso cha Chitetezo (Europe): s22-s24 / 25
Khodi yamayendedwe azinthu zoopsa: nonh pamayendedwe onse
Wgk Germany: 3
Nambala ya RTECS: dj2981400
Neohesperidin Literature
Kuyerekeza kwa kagayidwe kachakudya ndi zolembera za diploid yowirikiza kawiri ndi chitsa chake cha diploid citrus (C. junos cv. Ziyang xiangcheng) kukuwonetsa phindu lake lomwe lingakhalepo pakuwongolera kukana kupsinjika.
BMC Plant Biol.15, 89, (2015)
Polyploidy nthawi zambiri imaganiziridwa kuti imathandizira zomera kuti zigwirizane ndi zovuta zachilengedwe.Mizu ya citrus ya Tetraploid ikuyembekezeka kukhala ndi kupirira kwamphamvu kuposa diploid.Zambiri...
Ougan (Citrus reticulata cv. Suavissima) flavedo extract imachepetsa kusuntha kwa khansa posokoneza kusintha kwa epithelial-to-mesenchymal mu maselo a SKOV3.
Chin.Med.10, 14, (2015)
Ougan (Citrus reticulata cv. Suavissima) flavedo extract (OFE) adawonetsa zotsatira zotsutsana ndi chotupa ndi njira zosadziwika bwino.Kafukufukuyu akufuna kuwunika zomwe zitha kukhala zotsutsana ndi metastatic acti...
Hesperidin, nobiletin, ndi tangeretin onse ali ndi udindo pa anti-neuroinflammatory mphamvu ya tangerine peel (Citri reticulatae pericarpium).
Chem Chakudya.Toxicol.71 , 176-82, (2014)
Kuletsa microglial activation-mediated neuroinflammation kwakhala chandamale chokhutiritsa pakupanga zakudya zogwira ntchito pochiza matenda a neurodegenerative.Peel ya tangerine (Citri reticulata ...
English Alias Of Neohesperidin
HESPERETIN-7-NEOHESPERIDOSIDE
Hesperetin7-neohesperidoside
4H-1-Benzopyran-4-one, 7-[[2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy] -2,3-dihydro-5-hydroxy-2 -(3-hydroxy-4-methoxyphenyl)-, (2S)-
(2S) -5-Hydroxy-2-(3-hydroxy-4-methoxyphenyl) -4-oxo-3,4-dihydro-2H-chromen-7-yl 2-O-(6-deoxy-α-L- mannopyranosyl) -β-D-glucopyranoside
hesperetin 7-O-neohesperoside
Neohesperdin
Neohesperdin
Mtengo wa MFCD00017357
Hesperetin-7-O-neohesperidoside
EINECS 236-216-9
(S) -4'-Methoxy-3',5,7-trihydroxyflavanone-7-[2-O-(α-L-rhamnopyranosyl)-β-D-glucopyranoside]
4H-1-Benzopyran-4-one, 2,3-dihydro-7-((2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl)oxy) -5-hydroxy-2 -(3-hydroxy-4-methoxyphenyl)-, (S)-
Hesperetin 7-O-neohesperidoside
