Neohesperidin
Kushandiswa kweSynephrine Hydrochloride
Neohesperidin imhando ye flavonoid compound inowanikwa zvakanyanya muCucurbitaceae zvirimwa uye ine antioxidant uye anti-inflammatory effects./h2>
Zita reNeohesperidin
Chirungu Zita: neohesperidin
Chinese Alias: neohesperidin |neohesperidin
Bioactivity yeNeohesperidin
Tsanangudzo: neohesperidin is a flavonoid compound inowanikwa muCucurbitaceae, ine antioxidant uye anti-inflammatory effects.
Zvikamu zvinoenderana: chiratidzo nzira>> zvimwe>> zvimwe
research field > > kuzvimba / kusadzivirirwa
natural Products > > flavonoids
In Vitro Chidzidzo:
Nyowani hesperidin induces apoptosis mumunhu kenza yemazamu MDA-MB-231 masero.Iko IC50 tsika dze neohesperidin pa24 uye maawa 48 dzaive 47.4 ± 2.6, maererano μ M uye 32.5 ± 1.8 μ M. Kutaura kwe p53 neBax kwakanyatsogadziriswa mumasero akabatwa neohesperidin, apo kutaura kweBcl-2 kwaiva pasi. inodzorwa [1].Neohesperidin yakaratidza antioxidant basa muDPPH radical scavenging test (IC50 = 22.31 μ g/ mL) [2].
MuVivo Chidzidzo: neohesperidin (50mg / kg) yakanyanya kuvharirwa 55.0% HCl / ethanol inokonzera gastric kukuvara.Mune pylorus ligated rats, neohesperidin (50 mg / kg) yakaderedza zvakanyanya gastric secretion uye gastric acid kubuda uye kuwedzera pH [1].Neohesperidin kurapwa zvakanyanya kuderedza kutsanya kweropa reglucose, shuga yeropa uye glycosylated serum protein (GSP) mumakonzo.Yakawedzera zvakanyanya kushivirira kweglucose yemuromo uye insulin senitivity, uye yakaderedza insulin kusagadzikana mumakonzo ane chirwere cheshuga.Neohesperidin yakaderedza zvakanyanya serum triglycerides, cholesterol yakazara, leptin mazinga uye chiropa index mumakonzo [3].
Mhuka Kuedza: Mice: Mbeva dzose dzakatsanya maawa matanhatu isati yaedzwa, uye dzakadyiswa nemvura kana neohesperidin nekudyisa kumanikidzirwa.Kune OGTT uye ITT, mbeva dzakabaiwa intraperitoneally ne 2G / kg BW glucose kana 1iu / kg BW insulin, zvichiteerana.Zviyero zveropa zvakaunganidzwa kubva kune caudal vein kuyera basal blood glucose levels (0 maminetsi) isati yaiswa glucose kana insulini.Mamwe mazinga eglucose eropa akayerwa pa30, 60, 90 uye 120 maminitsi [3].
Reference:[1].Lee JH, nevamwe.Dziviriro mhedzisiro ye neohesperidin uye poncirin yakaparadzaniswa nemichero yePoncirus trifoliata pane inogona kuitika gastric chirwere.Phytother Res.2009 Dec;23(12):1748-53.
[2].Xu F, nevamwe.Neohesperidin induces cellular apoptosis muzamu remunhu adenocarcinoma MDA-MB-231 masero kuburikidza ne activating iyo Bcl-2/Bax-mediated signing nzira.Nat Prod Commun.2012 Nov;7(11):1475-8.
[3].Jia S, nevamwe.Hypoglycemic uye hypolipidemic zvinokonzerwa neohesperidin yakabva kuCitrus aurantium L. mune chirwere cheshuga KK-A (y) mice.Food Funct.2015 Mar;6(3):878-86.
Physicochemical Properties yeNeohesperidin
Density: 1.7 ± 0.1 g / cm3
Boiling Point: 933.7 ± 65.0 ° C pa 760 mmHg
Kunyungudika: 239-243 º C
Molecular Formula: C28H34O15
Molecular uremu: 610.561
Flash Point: 306.7 ± 27.8 ° C
Chaiyo Misa: 610.189758
PSA:234.29000
LogP:2.44
Chitarisiko: 0.0 ± 0.3 mmHg pa25 ° C
Steam Pressure: 0.0 ± 0.3 mmHg pa25 ° C
Refractive Index: 1.695
Kuchengetedza Mamiriro: 2-8 ° C
Nyowani Hesperidin Chengetedzo Ruzivo
Zvishandiso zvekuzvidzivirira nazvo: zvidzitiro zvemaziso;Gloves;mhando N95 (US);mhando P1 (EN143) respirator sefa
Chirevo Chekuchengetedza (Europe): s22-s24 / 25
Kodhi yekufambisa yezvinhu zvine njodzi: nonh yemhando dzese dzekutakura
Wgk Germany: 3
RTECS Nhamba: dj2981400
Neohesperidin Literature
Kuenzanisa kwemetabolism uye kunyorwa kwekuongorora kwe diploid yakapetwa kaviri uye diploid citrus rootstock (C. junos cv. Ziyang xiangcheng) inoratidza kukosha kwayo kunogona kuita kuti kusagadzikana kusagadzikana.
BMC Plant Biol.15 , 89, (2015)
Polyploidy yagara ichionekwa sekupa zvidyarwa kuchinjika zviri nani kune kushushikana kwezvakatipoteredza.Tetraploid citrus rootstocks inotarisirwa kuve nechisimba chakasimba kushivirira kupfuura diploid.Zvakawanda zve...
Ougan (Citrus reticulata cv. Suavissima) flavedo inobvisa inodzvinyirira kenza motility nekuvhiringidza epithelial-to-mesenchymal shanduko muSKOV3 masero.
Chin.Med.10 , 14, (2015)
Ougan (Citrus reticulata cv. Suavissima) flavedo extract (OFE) yakaratidza zvingangoita anti-bundu zvinokonzerwa nemaitiro asina kujeka ari pasi.Ichi chidzidzo chine chinangwa chekuongorora inogona kuita anti-metastatic acti ...
Hesperidin, nobiletin, uye tangeretin pamwe chete vanoita basa rekurwisa-neuroinflammatory simba re tangerine peel (Citri reticulatae pericarpium).
Food Chem.Toxicol.71 , 176-82, (2014)
Inhibiting microglial activation-mediated neuroinflammation yave chinangwa chinogutsa chekugadzirwa kwechikafu chinoshanda kurapa neurodegenerative zvirwere.Tangerine peel (Citri reticulata ...
Chirungu Alias Of Neohesperidin
HESPERETIN-7-NEOHESPERIDOSIDE
Hesperetin7-neohesperidoside
4H-1-Benzopyran-4-one, 7-[[2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy] -2,3-dihydro-5-hydroxy-2 -(3-hydroxy-4-methoxyphenyl)-, (2S)-
(2S)-5-Hydroxy-2-(3-hydroxy-4-methoxyphenyl) -4-oxo-3,4-dihydro-2H-chromen-7-yl 2-O-(6-deoxy-α-L- mannopyranosyl) -β-D-glucopyranoside
hesperetin 7-O-neohesperoside
Neohesperdin
Neohesperdin
MFCD00017357
Hesperetin-7-O-neohesperidoside
EINECS 236-216-9
(S) -4'-Methoxy-3',5,7-trihydroxyflavanone-7-[2-O-(α-L-rhamnopyranosyl)-β-D-glucopyranoside]
4H-1-Benzopyran-4-one, 2,3-dihydro-7-((2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl)oxy) -5-hydroxy-2 -(3-hydroxy-4-methoxyphenyl)-, (S)-
Hesperetin 7-O-neohesperidoside
