Kayayyaki

Bayani:glucoridin shine isoflavane daga glycorrhiza glabra, wanda zai iya ɗaure da kunna PPAR γ, ƙimar EC50 shine 6115 nm.Glabridin yana da antioxidant, antibacterial, anti glomerulonephritis, anti diabetes, anti-tumor, anti-inflammatory, anti osteoporosis, kare zuciya da jijiyoyin jini, kare jijiyoyi, scavenge free radicals da sauran ayyuka.

Rukunin masu alaƙa:filin bincike > > ciwon daji
Hanyar sigina > > sake zagayowar salula / lalata DNA > > PPAR
Filin bincike > > kumburi / rigakafi

A cikin Nazarin Vitro:glabridin yana ɗaure kuma yana kunna PPAR γ, EC50 shine 6115 nm [1].Glabridin (40,80 μ M) An hana yaduwar layin salula na SCC-9 da SAS a cikin kashi da kuma dogara da lokaci bayan 24 da 48 hours na jiyya [2].Glabridin (0-80 μM) Hakanan yana haifar da apoptosis, wanda ke haifar da kama tsarin kwayar halittar G1 a cikin SCC-9 da layin salula na SAS [2].Glabridin (0,20,40 da 80 μM) Kashi mai dogaro da aiki yana kunna Caspase-3, - 8 da - 9 kuma ya karu da raguwar PARP, mahimmancin phosphorylating ERK1 / 2, JNK1 / 2 da P-38 MAPK a cikin SCC-9.Kwayoyin halitta [2].

A cikin Nazarin Vivo:glabridin (50 MG / kg, Po sau ɗaya kowace rana) ya nuna aikin anti-mai kumburi mai ƙarfi kuma ya inganta sauye-sauyen kumburin da dextran sodium sulfate (DSS) ya haifar [3]

Magana:[1] Rebhun JF, et al.Gano glabridin a matsayin fili mai bioactive a cikin licorice (Glycyrrhiza glabra L.) tsantsa wanda ke kunna gamma mai karɓa na peroxisome proliferator-activated gamma (PPAR γ).Fitoterapia.2015 Oct;106:55-61.
[2].Chen CT, et al.Glabridin yana haifar da apoptosis da kama sake zagayowar tantanin halitta a cikin ƙwayoyin kansa na baka ta hanyar siginar JNK1/2.Environ Toxicol.2018 Yuni;33 (6): 679-685.
[3].El-Ashmawy NE, et al.Rage ƙa'idar iNOS da haɓakar cAMP suna daidaita tasirin anti-mai kumburi na glabridin a cikin berayen tare da ulcerative colitis.Inflammopharmacology.2018 Afrilu;26 (2): 551-559.