Ophiopogonin D Cas Nru.945619-74-9
Ophiopogon Saponin D Isem
Isem Ingliż:(1β,3β,25R)-3-Hydroxyspirost-5-en-1-yl 6-deoxy-α-L-mannopiranosil-(1->2)-[β-D-xylopyranosyl-(1->3)] -6-deoxy-β-D-galactopyranoside
Il-bijoattività ta' Ophiopogon Japonicus Saponin D
Deskrizzjoni:Ophiopogon D huwa glycoside sterojdi naturali rari C29 iżolat mit-tuberu ta 'Ophiopogon japonicus.Ophiopogonin D huwa induttur CYP2J3 li jżid CYP2J2 / eets u PPAR fiċ-ċelluli endoteljali tal-vini umbilikali tal-bniedem (HUVECs) α L-espressjoni ta 'Ang II inibit b'mod sinifikanti t-traslokazzjoni nukleari NF- κ B indotta minn Ang II, I κ B α Down regulation, Ca2 + intraċellulari tagħbija żejda u attivazzjoni ta 'ċitokini proinfjammatorji.Ophiopogonin D intuża biex jikkura infjammazzjoni u mard kardjovaskulari għal eluf ta 'snin.
Kategoriji Rilevanti
Mogħdija tas-sinjalar >> trasport transmembrana >> kanal tal-kalċju
Qasam tar-riċerka >> mard kardjovaskulari
Mogħdija tas-sinjalar >> ċiklu taċ-ċelluli / ħsara fid-DNA >> PPAR
Qasam tar-riċerka >> infjammazzjoni / immunità
Mira
PPARα
NF-κB
Ca2+
Dokumenti ta' Referenza:[1].Wang L, et al.Homo-aro-cholestane, furostane u spirostane saponins mit-tuberi ta 'Ophiopogonjaponicus.Fitokimika.2017 Apr;136:125-132.
[2].Huang X, et al.Ophiopogonin D u EETs itejbu r-risponsi infjammatorji indotti minn Ang II permezz tal-attivazzjoni ta' PPARα f'HUVECs.Biochem Biophys Res Commun.2017 Awissu 19;490(2):123-133.
Psewdonimu Ingliż ta' Ophiopogon saponin D
(1β,3β,25R)-3-Hydroxyspirost-5-en-1-yl 6-deoxy-α-L-mannopiranosil-(1->2)-[β-D-xylopyranosyl-(1->3)] -6-deoxy-β-D-galactopyranoside β-D-Galactopyranoside, (1β,3β,25R)-3-hydroxyspirost-5-en-1-yl O-6-deoxy-α-L-mannopyranosyl-(1- >2)-O-[β-D-xylopyranosyl-(1->3)]-6-deoxy-
(2S,3R,4R,5R,6S)-2-(((2R,3R,4S,5S,6R)-5-idrossi-2-(((4R,5'R,6R,6aR,6bS,8aS) ,8bR,9S,10R,11aS,12aS,12bS)-4-idrossi-5',6a,8a,9-tetramethyl-1,3,3',4,4',5,5',6,6a, 6b,6',7,8,8a,8b,9,11a,12,12a,12b-icosahydrospiro[naphtho[2',1':4,5]indeno[2,1-b]furan-10,2 '-piran]-6-il)ossi)-6-metil-4-(((2S,3R,4S,5R)-3,4,5-triidrossitetraidro-2H-piran-2-il)ossi)tetraidro- 2H-pyran-3-il)ossi)-6-metiltetraidro-2H-piran-3,4,5-triol
Ophiopogonin D
Deacetylophiopogonin C
