Ophiopogonin D Cas No.945619-74-9
Ophiopogon Saponin D Navn
Engelsk navn:(1β,3β,25R)-3-Hydroxyspirost-5-en-1-yl-6-deoxy-α-L-mannopyranosyl-(1->2)-[β-D-xylopyranosyl-(1->3)] -6-deoxy-β-D-galactopyranosid
Bioaktivitet af Ophiopogon Japonicus Saponin D
Beskrivelse:Ophiopogon D er et sjældent naturligt C29 steroid glycosid isoleret fra knolden af Ophiopogon japonicus.Ophiopogonin D er en CYP2J3-inducer, der øger CYP2J2 / eets og PPAR i humane umbilical vene endotelceller (HUVEC'er) α Ekspressionen af Ang II hæmmede signifikant Ang II induceret NF- κ B nuklear translokation, I κ B α α Down regulering, intracellulær Ca Down regulering, overbelastning og aktivering af proinflammatoriske cytokiner.Ophiopogonin D er blevet brugt til at behandle inflammation og hjerte-kar-sygdomme i tusinder af år.
Relevante kategorier
Signalvej > > transmembran transport > > calciumkanal
Forskningsområde >> hjerte-kar-sygdomme
Signaleringsvej > > cellecyklus / DNA-skade > > PPAR
Forskningsområde >> inflammation/immunitet
Mål
PPARa
NF-KB
Ca2+
Referencedokumenter:[1].Wang L, et al.Homo-aro-cholestane, furostane og spirostane saponiner fra knoldene af Ophiopogonjaponicus.Fytokemi.2017 Apr;136:125-132.
[2].Huang X, et al.Ophiopogonin D og EET'er forbedrer Ang II-inducerede inflammatoriske reaktioner via aktivering af PPARα i HUVEC'er.Biochem Biophys Res Commun.2017 19. august;490(2):123-133.
Engelsk alias for Ophiopogon saponin D
(1β,3β,25R)-3-Hydroxyspirost-5-en-1-yl-6-deoxy-α-L-mannopyranosyl-(1->2)-[β-D-xylopyranosyl-(1->3)] -6-deoxy-β-D-galactopyranosid β-D-Galactopyranosid, (1β,3β,25R)-3-hydroxyspirost-5-en-1-yl O-6-deoxy-α-L-mannopyranosyl-(1- >2)-O-[β-D-xylopyranosyl-(1->3)]-6-deoxy-
(2S,3R,4R,5R,6S)-2-(((2R,3R,4S,5S,6R)-5-hydroxy-2-(((4R,5'R,6R,6aR,6bS,8aS) ,8bR,9S,10R,11aS,12aS,12bS)-4-hydroxy-5',6a,8a,9-tetramethyl-1,3,3',4,4',5,5',6,6a, 6b,6',7,8,8a,8b,9,11a,12,12a,12b-icosahydrospiro[naphtho[2',1':4,5]indeno[2,1-b]furan-10,2 '-pyran]-6-yl)oxy)-6-methyl-4-(((2S,3R,4S,5R)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)oxy)tetrahydro- 2H-pyran-3-yl)oxy)-6-methyltetrahydro-2H-pyran-3,4,5-triol
Ophiopogonin D
Deacetylophiopogonin C
