3-Hydroxy-9,10-dimethoxyptercarpan, Methylnissolin
Gukoresha Methylnissolin
Methylnisolin (astrapterocarpan) yitandukanije na Astragalus membranaceus kandi irashobora kubuza ikwirakwizwa ry'uturemangingo iterwa no gukura kwa platine (PDGF) - BB, hamwe na IC50 ya 10 μ M。 Methylnisolin ibuza fosifora yerekana ibimenyetso bidasanzwe bigengwa na kinase 1/2 (eric1 / 2) mitogen ikora protein (ikarita) kinase iterwa na PDGF-BB.Methylnisolin ibuza PDGF-BB iterwa no gukwirakwira kwingirangingo zimitsi itwara imitsi ihagarika ERK1 / 2 MAP kinase cascade.
Izina rya Methylnissolin
Izina ry'icyongereza:
(-) - 6aR, 11aR-dihydro-3-hydroxy-9,10-dimethoxy-6H-benzofuro [3,2-c] [1] -benzopyran
Abashinwa Alias: 3-hydroxy-9,10-dimethoxy sandalwood itukura |Astragalus itukura
sandalwood |(6aR, 11ar) - 3-hydroxy-9,10-dimethoxy sandali itukura
Igikorwa cyibinyabuzima cya Methylnissolin
Ibisobanuro: methylnisolin (astrapterocarpan) yitandukanije na Astragalus membranaceus
kandi irashobora kubuza ikwirakwizwa ry'uturemangingo iterwa no gukura kwa platine (PDGF) - BB.
IC50 ni 10 μ M。 Methylnisolin ibuza fosifora yikimenyetso kidasanzwe
kugenga kinase 1/2 (eric1 / 2) mitogen ikora protein (ikarita) kinase iterwa na
PDGF-BB.Methylnisolin ibuza PDGF-BB iterwa no gukwirakwira kwamaraso
ingirangingo z'imitsi muguhagarika ERK1 / 2 MAP kinase cascade.
Ibyiciro bifitanye isano: umurima wubushakashatsi >> Indwara yumutima
inzira yinzira >> protein tyrosine kinase >> PDGFR
inzira y'ibimenyetso >> MAPK / ERK inzira y'ibimenyetso >> ERK
inzira yerekana inzira >> ingirabuzimafatizo hamwe na Wnt inzira >> ERK
Intego: PDGFR: 10 μM (IC50)
ERK1
ERK2
Reba: [1].Ohkawara S, n'abandi.Astrapterocarpan yitandukanije na Astragalus membranaceus ibuza ikwirakwizwa ry'uturemangingo tworoheje twimitsi.Eur J Pharmacol.2005 Ugushyingo 21; 525 (1-3): 41-7.
Imiterere ya fiziki ya chimique ya Methylnissolin
Ubucucike: 1,3 ± 0.1 g / cm3
Ingingo yo guteka: 428.9 ± 45.0 ° C kuri 760 mmHg
Inzira ya molekulari: c17h16o5
Uburemere bwa molekuline: 300.306
Ingingo ya Flash: 213.2 ± 28.7 ° C.
Misa nyayo: 300.099762
PSA: 57.15000
LogP: 2.45
Umuvuduko wamazi: 0.0 ± 1,1 mmHg kuri 25 ° C.
Ironderero: 1.612
Jiangsu Yongjian Pharmaceutical Technology Co., Ltd.
Jiangsu Yongjian Pharmaceutical Technology Co., Ltd., yashinzwe muri Werurwe 2012, ni ikigo cy’ikoranabuhanga rikomeye rihuza R & D, umusaruro no kugurisha.Ifite cyane cyane mubikorwa byo gutunganya, gutunganya no gutunganya umusaruro wibikorwa byibicuruzwa bisanzwe, ibikoresho gakondo bivura imiti yubushinwa hamwe n’ibiyobyabwenge.Isosiyete iherereye mu Bushinwa bw’imiti mu Bushinwa, Umujyi wa Taizhou, Intara ya Jiangsu, harimo n’umusaruro wa metero kare 5000 na metero kare 2000 & R & D.Ikora cyane cyane mubigo bikomeye byubushakashatsi bwa siyanse, kaminuza hamwe ninganda zitunganya ibicuruzwa mu gihugu hose.
Kugeza ubu, twateje imbere amoko arenga 1500 y’ibinyabuzima bisanzwe, kandi tugereranya kandi uhinduranya ubwoko burenga 300 bwibikoresho bifatika, bushobora kuzuza byimazeyo ubugenzuzi bwa buri munsi bwibigo bikomeye byubushakashatsi bwa siyansi, laboratoire za kaminuza hamwe n’inganda zikora ibicuruzwa.
Dushingiye ku ihame ryo kwizera kwiza, isosiyete irizera gufatanya byimazeyo nabakiriya bacu.Intego yacu ni ugukora ivugurura ry'ubuvuzi gakondo bw'Abashinwa.
Ibyiza byubucuruzi Bwisosiyete
1. R & D, gukora no kugurisha ibikoresho bivura imiti yubuvuzi gakondo bwabashinwa;
2. Guhindura imiti gakondo yubuvuzi bwa monomer ukurikije ibiranga abakiriya
3. Ubushakashatsi ku bipimo ngenderwaho no guteza imbere imiti gakondo y’Ubushinwa (ibimera)
4. Ubufatanye bwikoranabuhanga, kwimura nubushakashatsi bushya bwibiyobyabwenge niterambere.
