Eyona 3-Hydroxy-9,10-dimethoxyptercarpan,Methylnissolin Manufacturer kunye neFactory |Yongjian

3-Hydroxy-9,10-dimethoxyptercarpan,Methylnissolin

Inkcazelo emfutshane:

Igama eliqhelekileyo: iMeidi red sandalwood element

Igama lesiNgesi: methylnissolin

Inombolo yeCAS: 73340-41-7

Ubunzima beMolekyuli: 300.306

Ubuninzi: 1.3 ± 0.1 g / cm3

Indawo yokuBilisa: 428.9 ± 45.0 ° C kwi-760 mmHg

Ifomula yemolekyuli: C17H16O5

Indawo ekunyibilika kuyo: nN/ A

I-MSDS: N/A

Indawo eDibanisayo: 213.2 ± 28.7 ° C

Thumela i-imeyile kuthi

Iinkcukacha zeMveliso

Iithegi zeMveliso

Ukusetyenziswa kweMethylnissolin

I-Methylnisolin (astrapterocarpan) ihlukaniswe kwi-Astragalus membranaceus kwaye inokuthintela ukwanda kweeseli ezibangelwa yi-platelet-derived growth factor (PDGF) - BB, kunye ne-IC50 ye-10 μ M. I-2) iprotheni esebenzayo ye-mitogen (imephu) kinase eyenziwa yi-PDGF-BB.I-Methylnisolin inqanda i-PDGF-BB eyenza ukwanda kweeseli ze-vascular smooth muscle ngokuvimbela i-ERK1 / 2 MAP kinase cascade.

Igama leMethylnissolin

Igama lesiNgesi:

(-)-6aR,11aR-dihydro-3-hydroxy-9,10-dimethoxy-6H-benzofuro[3,2-c][1]-benzopyran

I-Alias yaseTshayina: i-3-hydroxy-9,10-dimethoxy ebomvu ye-sandalwood |I-Astragalus ebomvu

sandalwood |(6aR, 11ar) - 3-hydroxy-9,10-dimethoxy sandalwood ebomvu

Umsebenzi webhayoloji weMethylnissolin

Inkcazo: i-methylnisolin (astrapterocarpan) ihlukaniswe kwi-Astragalus membranaceus

kwaye inokuthintela ukwanda kweeseli ezibangelwa yi-platelet-derived growth factor (PDGF) - BB.

I-IC50 yi-10 μ M. I-Methylnisolin inqanda i-phosphorylation ye-extracellular signal

i-regulated kinase 1/2 (eric1 / 2) mitogen activated protein (map) kinase eyenziwa ngu

PDGF-BB.I-Methylnisolin inqanda i-PDGF-BB eyenza ukwanda kwe-vascular smooth

iiseli zezihlunu ngokuthintela ERK1 / 2 MAP kinase cascade.

Iindidi ezinxulumeneyo: intsimi yophando > > isifo senhliziyo

indlela yomqondiso > > iprotheni tyrosine kinase > > PDGFR

indlela yomqondiso > > MAPK / indlela yesignali ye-ERK > > ERK

indlela yokubonisa > > iiseli zestem kunye ne-Wnt pathway > > ERK

Umbaliso:PDGFR:10 μM (IC50)

ERK1

ERK2

Imbekiselo:[1].Ohkawara S, et al.I-Astrapterocarpan eyedwa kwi-Astragalus membranaceus inqanda ukwanda kweeseli ze-vascular smooth muscle.Eur J Pharmacol.2005 Nov 21;525(1-3):41-7.

Iimpawu zePhysicochemical zeMethylnissolin

Ubuninzi: 1.3 ± 0.1 g / cm3

Indawo yokuBilisa: 428.9 ± 45.0 ° C kwi-760 mmHg

Ifomula yemolekyuli: c17h16o5

Ubunzima beMolekyuli: 300.306

Indawo eDibanisayo: 213.2 ± 28.7 ° C

Ubunzima obuchanekileyo: 300.099762

PSA:57.15000

IlogP:2.45

Uxinzelelo lomphunga: 0.0 ± 1.1 mmHg ku-25 ° C

Refractive Index: 1.612

Jiangsu Yongjian Pharmaceutical Technology Co., Ltd.

I-Jiangsu Yongjian Pharmaceutical Technology Co., Ltd., esekwe ngoMatshi ka-2012, lishishini lobugcisa obuphezulu elidibanisa i-R & D, imveliso kunye neentengiso.Isebenza ikakhulu kwimveliso, uhlengahlengiso kunye nophuhliso lwenkqubo yemveliso yamacandelo asebenzayo emveliso yendalo, izixhobo zesalathiso samayeza esintu kunye nokungcola kweziyobisi.Inkampani ifumaneka kwisiXeko sase-China se-Pharmaceutical City, kwisiXeko saseTaizhou, kwiPhondo laseJiangsu, kubandakanywa nesiseko sokuvelisa i-5000 ye-square meter kunye ne-2000 ye-square meter ye-R & D isiseko.Isebenza ikakhulu kumaziko ophando lwenzululwazi, iiyunivesithi kunye namashishini emveliso ye-decoction kwilizwe lonke.

Ukuza kuthi ga ngoku, siye savelisa ngaphezu kwe-1500 iintlobo ze-reagents zekhompawundi zendalo, kwaye sithelekisa kwaye salinganisa ngaphezu kwe-300 iintlobo zezixhobo zereferensi, ezinokuhlangabezana ngokupheleleyo neemfuno zokuhlolwa kwemihla ngemihla zamaziko ophando lwenzululwazi, iilebhu zeyunivesithi kunye namashishini okuvelisa amaqhekeza e-decoction.

Ngokusekwe kumgaqo wokholo oluhle, inkampani inethemba lokusebenzisana ngokunyanisekileyo nabathengi bethu.Injongo yethu kukusebenzela ukuphuculwa kwamayeza emveli aseTshayina.