3-Hydroxy-9,10-dimethoxyptercarpan,Methylnissolin
Ohun elo Methylnissolin
Methylnisolin (astrapterocarpan) ti ya sọtọ lati Astragalus membranaceus ati pe o le ṣe idiwọ imugboroja sẹẹli ti o fa nipasẹ ipadabọ idagbasoke ti platelet (PDGF) - BB, pẹlu IC50 ti 10 μ M. 2) amuaradagba ti a mu ṣiṣẹ mitogen (maapu) kinase ti a fa nipasẹ PDGF-BB.Methylnisolin ṣe idiwọ PDGF-BB ti o fa ilọsiwaju ti awọn sẹẹli isan iṣan ti iṣan nipa didi ERK1 / 2 MAP kinase cascade.
Orukọ Methylnissolin
Orukọ Gẹẹsi:
(-)-6aR,11aR-dihydro-3-hydroxy-9,10-dimethoxy-6H-benzofuro[3,2-c] [1] -benzopyran
Chinese inagijẹ: 3-hydroxy-9,10-dimethoxy pupa sandalwood |Astragalus pupa
sandalwood |(6aR, 11ar) - 3-hydroxy-9,10-dimethoxy pupa sandalwood
Iṣẹ iṣe ti Methylnissolin
Apejuwe: methylnisolin (astrapterocarpan) ti ya sọtọ lati Astragalus membranaceus
ati pe o le ṣe idiwọ ilọsiwaju sẹẹli ti o fa nipasẹ ipadabọ idagbasoke ti platelet (PDGF) - BB.
IC50 jẹ 10 μM. Methylnisolin ṣe idiwọ phosphorylation ti ifihan agbara extracellular
kinase ti a ṣe ilana 1/2 (eric1/2) amuaradagba mitogen ti a mu ṣiṣẹ (maapu) kinase fa nipasẹ
PDGF-BB.Methylnisolin ṣe idiwọ PDGF-BB ti o ni ilọsiwaju ti iṣan ti iṣan
awọn sẹẹli iṣan nipa didi ERK1 / 2 MAP kinase cascade.
Awọn ẹka ti o jọmọ: aaye iwadii> Arun inu ọkan ati ẹjẹ
ọna ifihan agbara > > amuaradagba tyrosine kinase > > PDGFR
Ona ifihan agbara > > MAPK / Ona ifihan agbara ERK > ERK
ipa ọna ifihan>> awọn sẹẹli yio ati ọna Wnt>> ERK
Ipalara: PDGFR: 10 μM (IC50)
ERK1
ERK2
Itọkasi:[1].Ohkawara S, et al.Astrapterocarpan ti o ya sọtọ lati Astragalus membranaceus ṣe idiwọ ilọsiwaju ti awọn sẹẹli isan dan ti iṣan.Eur J Pharmacol.2005 Kọkànlá Oṣù 21; 525 (1-3): 41-7.
Awọn ohun-ini kẹmika ti Methylnissolin
iwuwo: 1.3 ± 0.1 g / cm3
Ojuami Sise: 428.9 ± 45.0 ° C ni 760 mmHg
Ilana molikula: c17h16o5
Iwọn Molikula: 300.306
Ojuami Filasi: 213.2 ± 28.7 ° C
Iwọn deede: 300.099762
PSA: 57.15000
LogP:2.45
Titẹ Nya si: 0.0 ± 1.1 mmHg ni 25 ° C
Atọka itọka: 1.612
Jiangsu Yongjian Pharmaceutical Technology Co., Ltd.
Jiangsu Yongjian Pharmaceutical Technology Co., Ltd., ti iṣeto ni Oṣu Kẹta 2012, jẹ ile-iṣẹ imọ-ẹrọ giga ti o ṣepọ R & D, iṣelọpọ ati tita.O ti wa ni o kun npe ni isejade, isọdi ati gbóògì ilana idagbasoke ti nṣiṣe lọwọ irinše ti adayeba awọn ọja, ibile Chinese oogun itọkasi ohun elo ati ki o oògùn impurities.Ile-iṣẹ naa wa ni Ilu elegbogi Ilu China, Ilu Taizhou, Agbegbe Jiangsu, pẹlu ipilẹ iṣelọpọ 5000 square mita ati ipilẹ 2000 square mita R & D.O kun ṣe iranṣẹ awọn ile-iṣẹ iwadii imọ-jinlẹ pataki, awọn ile-ẹkọ giga ati awọn ile-iṣẹ iṣelọpọ nkan decoction kọja orilẹ-ede naa.
Nitorinaa, a ti ni idagbasoke diẹ sii ju awọn iru 1500 ti awọn ohun elo idapọmọra adayeba, ati ṣe afiwe ati ṣe iwọn diẹ sii ju awọn iru awọn ohun elo itọkasi 300, eyiti o le ni kikun pade awọn iwulo ayewo ojoojumọ ti awọn ile-iṣẹ iwadii imọ-jinlẹ pataki, awọn ile-ẹkọ giga ile-ẹkọ giga ati awọn ile-iṣẹ iṣelọpọ awọn ege decoction.
Da lori ilana ti igbagbọ to dara, ile-iṣẹ nireti lati ṣe ifowosowopo pẹlu awọn alabara wa.Ero wa ni lati sin isọdọtun ti oogun Kannada ibile.
Anfani Business Dopin Of The ile-
1. R & D, iṣelọpọ ati tita awọn ohun elo itọkasi kemikali ti oogun Kannada ibile;
2. Awọn agbo ogun monomer oogun Kannada ti aṣa ni ibamu si awọn abuda alabara
3. Iwadi lori boṣewa didara ati idagbasoke ilana ti oogun Kannada ibile (ọgbin) jade
4. Ifowosowopo ọna ẹrọ, gbigbe ati iwadi titun oògùn ati idagbasoke.
