3-Hydroxy-9,10-dimethoxyptercarpan,Methylnissolin
Kugwiritsa ntchito Methylnissolin
Methylnisolin (astrapterocarpan) imakhala yotalikirana ndi Astragalus membranaceus ndipo imatha kuletsa kuchuluka kwa maselo opangidwa ndi ma platelet-derived growth factor (PDGF) - BB, yokhala ndi IC50 ya 10 μ M. Methylnisolin imalepheretsa phosphorylation ya extracellular sign regulated kinase 1 / 2 2) mapuloteni opangidwa ndi mitogen (mapu) kinase opangidwa ndi PDGF-BB.Methylnisolin imalepheretsa PDGF-BB kuchulukitsa kwa maselo osalala a minofu mwa kuletsa ERK1 / 2 MAP kinase cascade.
Dzina la Methylnissolin
Dzina la Chingerezi:
(-) -6aR,11aR-dihydro-3-hydroxy-9,10-dimethoxy-6H-benzofuro[3,2-c][1]-benzopyran
Dzina lachi China: 3-hydroxy-9,10-dimethoxy red sandalwood |Astragalus wofiira
sandalwood |(6aR, 11ar) - 3-hydroxy-9,10-dimethoxy red sandalwood
Biological Activity ya Methylnissolin
Kufotokozera: methylnisolin (astrapterocarpan) yalekanitsidwa ndi Astragalus membranaceus
ndipo imatha kuletsa kuchuluka kwa maselo opangidwa ndi mapulateleti otengedwa ndi kukula kwa chinthu (PDGF) - BB.
IC50 ndi 10 μ M. Methylnisolin imalepheretsa phosphorylation ya chizindikiro cha extracellular.
regulated kinase 1 / 2 (eric1 / 2) mitogen activated protein (mapu) kinase opangidwa ndi
Chithunzi cha PDGF-BB.Methylnisolin imalepheretsa PDGF-BB kuchulukitsa kwa mitsempha yosalala
ma cell a minofu poletsa ERK1 / 2 MAP kinase cascade.
Magulu Ofananira: gawo lofufuzira>> matenda amtima
njira yolumikizira>> protein tyrosine kinase>> PDGFR
njira yolumikizira>> MAPK / ERK njira yolumikizira>> ERK
njira yolumikizira>> ma cell stem ndi njira ya Wnt>> ERK
Chikhalidwe:PDGFR:10 μM (IC50)
ERK1
ERK2
Buku:[1].Ohkawara S, et al.Astrapterocarpan yotalikirana ndi Astragalus membranaceus imalepheretsa kuchuluka kwa maselo osalala a minofu.Eur J Pharmacol.2005 Nov 21; 525 (1-3): 41-7.
Physicochemical katundu wa Methylnissolin
Kachulukidwe: 1.3 ± 0.1 g / cm3
Malo Owira: 428.9 ± 45.0 ° C pa 760 mmHg
Fomula ya mamolekyu: c17h16o5
Molecular Kulemera kwake: 300.306
Flash Point: 213.2 ± 28.7 ° C
Kuchuluka Kwambiri: 300.099762
PSA: 57.15000
Chizindikiro: 2.45
Kuthamanga kwa Steam: 0.0 ± 1.1 mmHg pa 25 ° C
Refractive Index: 1.612
Malingaliro a kampani Jiangsu Yongjian Pharmaceutical Technology Co., Ltd.
Jiangsu Yongjian Pharmaceutical Technology Co., Ltd., yomwe idakhazikitsidwa mu Marichi 2012, ndi bizinesi yapamwamba kwambiri yophatikiza R & D, kupanga ndi kugulitsa.Iwo makamaka chinkhoswe mu kupanga, makonda ndi kupanga ndondomeko chitukuko cha yogwira zigawo zikuluzikulu za zinthu zachilengedwe, chikhalidwe Chinese mankhwala Buku zipangizo ndi zosafunika mankhwala.Kampaniyo ili ku China Pharmaceutical City, Taizhou City, Province la Jiangsu, kuphatikiza malo opangira masikweya mita 5000 ndi maziko a 2000 square metre R & D.Imagwira makamaka mabungwe akuluakulu ofufuza zasayansi, mayunivesite ndi mabizinesi opanga zidutswa za decoction m'dziko lonselo.
Pakalipano, tapanga mitundu yoposa 1500 ya ma reagents achilengedwe, ndikuyerekeza ndikuyesa mitundu yopitilira 300 yazinthu zofananira, zomwe zimatha kukwaniritsa zosowa zatsiku ndi tsiku za mabungwe akuluakulu asayansi asayansi, ma laboratories aku yunivesite ndi mabizinesi opangira decoction.
Kutengera mfundo ya chikhulupiriro chabwino, kampani ikuyembekeza kugwirizana moona mtima ndi makasitomala athu.Cholinga chathu ndikupereka chithandizo chamakono chamankhwala achi China.
Ubwino Wopanga Bizinesi Yamakampani
1. R & D, kupanga ndi kugulitsa zinthu zofotokozera za mankhwala achi China;
2. Makonda chikhalidwe Chinese mankhwala monomer mankhwala malinga ndi makhalidwe kasitomala
3. Kafukufuku wamakhalidwe abwino komanso chitukuko chamankhwala achi China (chomera).
4. Kugwirizana kwaukadaulo, kusamutsa ndi kafukufuku watsopano wamankhwala ndi chitukuko.
