3-Hydroxy-9,10-dimethoxyptercarpan,Methylnissolin
Te tono mo te Methylnissolin
Ko te Methylnisolin (astrapterocarpan) ka wehea mai i te Astragalus membranaceus ka taea te aukati i te tipu o te pūtau i whakaawehia e te tauwehe tipu i ahu mai i te platelet (PDGF) - BB, me te IC50 o te 10 μ M. Ka whakakorehia e te Methylnisolin te phosphorylation o te tohu extracellular kinase 1 / 2 (ericed kinase 1 / 2). 2) mitogen activated protein (mahere) kinase na te PDGF-BB.Ko te Methylnisolin te aukati i te PDGF-BB i te whakanui i te tipu o nga uaua maeneene maeneene ma te aukati i te ERK1 / 2 MAP kinase cascade.
Ingoa o Methylnissolin
Ingoa Ingarihi:
(-)-6aR,11aR-dihydro-3-hydroxy-9,10-dimethoxy-6H-benzofuro[3,2-c][1]-benzopyran
Ingoa Hainamana: 3-hydroxy-9,10-dimethoxy red sandalwood |Astragalus whero
aramuka |(6aR, 11ar) - 3-hydroxy-9,10-dimethoxy aramuka whero
Mahi Koiora o Methylnissolin
Whakaahuatanga: Ko te methylnisolin (astrapterocarpan) ka wehea mai i te Astragalus membranaceus
a ka taea te aukati i te pikinga o te pūtau i whakaawehia e te tauwehe tipu i ahu mai i te platelet (PDGF) - BB.
Ko te IC50 he 10 μ M. Methylnisolin te aukati i te phosphorylation o te tohu extracellular.
kinase kua whakaritea 1/2 (eric1/2) pūmua whakahohe mitogen (mapi) kinase i whakaawehia e
PDGF-BB.Ko te Methylnisolin te aukati i te PDGF-BB i te tipu o te maeneene vascular
pūtau uaua mā te aukati i te ERK1 / 2 MAP kinase cascade.
Nga waahanga e pa ana: rangahau mara > > mate ngakau
ara tohu > > pūmua tyrosine kinase > > PDGFR
ara tohu > > MAPK / ERK ara tohu > > ERK
ara tohu > > pūtau kakau me te ara Wnt > > ERK
Traget:PDGFR:10 μM (IC50)
ERK1
ERK2
Tohutoro:[1].Ohkawara S, et al.Ko te Astrapterocarpan kua wehea mai i te Astragalus membranaceus ka aukati i te tipu o nga pūtau uaua maeneene.Eur J Pharmacol.2005 Whiringa-ā-rangi 21;525(1-3):41-7.
Nga ahuatanga matū tinana o Methylnissolin
Kiato: 1.3 ± 0.1 g / cm3
Kohuatanga: 428.9 ± 45.0 ° C i te 760 mmHg
Tātai rāpoi: c17h16o5
Taumaha rāpoi: 300.306
Ira Kohiko: 213.2 ± 28.7 ° C
Papatipu Tika: 300.099762
PSA:57.15000
RangitakiP:2.45
Te Peehanga Maamaa: 0.0 ± 1.1 mmHg i te 25 ° C
Taurangi Whakaata: 1.612
Jiangsu Yongjian Pharmaceutical Technology Co., Ltd.
Ko Jiangsu Yongjian Pharmaceutical Technology Co., Ltd., i whakapumautia i te Maehe 2012, he hinonga hangarau-nui e whakauru ana i te R&D, te whakaputa me te hoko.Ko te nuinga o te mahi i roto i te hanga, te whakarite me te whakawhanaketanga tukanga whakaputa o nga waahanga kaha o nga hua taiao, nga taonga tohutoro rongoa Hainamana tuku iho me nga poke tarukino.Ko te kamupene kei roto China Pharmaceutical City, Taizhou City, Jiangsu Province, tae atu ki te 5000 mita tapawha turanga hanga me te 2000 mita tapawha R & D turanga.Ko te nuinga kei te mahi i nga whare rangahau putaiao nui, whare wananga me nga hinonga whakangao hupa puta noa i te motu.
I tenei wa, kua whakawhanakehia e matou neke atu i te 1500 nga momo reagents taiao, me te whakataurite me te whakataurite neke atu i te 300 momo rauemi tohutoro, ka taea te whakatutuki i nga hiahia tirotiro o ia ra o nga whare rangahau putaiao nui, whare taiwhanga whare wananga me nga hinonga whakaputa decoction.
I runga i te kaupapa o te whakapono pai, e tumanako ana te kamupene ki te mahi tahi me o taatau kaihoko.Ko ta matou whainga ko te mahi i te whakahoutanga o nga rongoa Hainamana tuku iho.
Te Mahinga Pakihi Painga o te kamupene
1. R & D, hanga me te hoko o nga rauemi tohutoro matū o te rongoa Hainamana tuku iho;
2. Whakaritea nga pūhui monomer rongoa Hainamana tuku iho kia rite ki nga ahuatanga o te kaihoko
3. Te rangahau mo te paerewa kounga me te whakawhanaketanga tukanga o te rongoa Hainamana (tipu) tangohanga
4. Hangarau mahi tahi, whakawhiti me te rangahau tarukino hou me te whanaketanga.
