3-Hydroxy-9,10-dimethoxyptercarpan, Methylnissolin.
Ngwa nke Methylnissolin
Methylnisolin (astrapterocarpan) dịpụrụ adịpụ site na Astragalus membranaceus ma nwee ike igbochi mgbasawanye cell na-ebute site na ihe na-eto eto na-emepụta platelet (PDGF) - BB, na IC50 nke 10 μ M. 2) protein mitogen na-arụ ọrụ (map) kinase nke PDGF-BB kpatara.Methylnisolin na-egbochi PDGF-BB na-ebute mmụba nke mkpụrụ ndụ akwara dị nro site na igbochi ERK1 / 2 MAP kinase cascade.
Aha nke Methylnissolin
Aha Bekee:
(-)-6aR,11aR-dihydro-3-hydroxy-9,10-dimethoxy-6H-benzofuro[3,2-c] [1]-benzopyran
Utu aha Chinese: 3-hydroxy-9,10-dimethoxy red sandalwood |Astragalus uhie
sandalwood |(6aR, 11ar) - 3-hydroxy-9,10-dimethoxy red sandalwood
Ọrụ ndu nke Methylnissolin
Nkọwa: methylnisolin (astrapterocarpan) dịpụrụ adịpụ na Astragalus membranaceus
ma nwee ike igbochi mgbasawanye cell nke sitere na ihe na-eto eto na-enweta platelet (PDGF) - BB.
IC50 bụ 10 μM. Methylnisolin na-egbochi phosphorylation nke mgbaàmà extracellular.
kinase 1/2 na-achịkwa (eric1/2) protein mitogen na-arụ ọrụ (map) kinase kpatara ya.
PDGF-BB.Methylnisolin na-egbochi PDGF-BB na-ebute mmụba nke akwara dị nro
mkpụrụ ndụ akwara site na igbochi ERK1 / 2 MAP kinase cascade.
Ụdị emetụtara: ubi nyocha > > ọrịa obi
ụzọ mgbama > > protein tyrosine kinase > > PDGFR
Ụzọ mgbama > > MAPK / ERK ụzọ mgbama > > ERK
Ụzọ mgbaama >> sel stem na ụzọ Wnt>> ERK
Ihe kpatara: PDGFR: 10 μM (IC50)
ERK1
ERK2
Ntụaka:[1].Ohkawara S, et al.Astrapterocarpan dịpụrụ adịpụ na Astragalus membranaceus na-egbochi mmụba nke mkpụrụ ndụ akwara dị nro.Eur J Pharmacol.2005 Nov 21;525 (1-3): 41-7 .
Njirimara physicochemical nke Methylnissolin
Njupụta: 1.3 ± 0.1 g / cm3
Ebe esi esi: 428.9 ± 45.0 ° C na 760 mmHg
Ụdị ihe omimi: c17h16o5
Arọ Molecular: 300.306
Ebe ọkụ: 213.2 ± 28.7 Celsius C
Mass ziri ezi: 300.099762
PSA: 57.15000
Ihe ndekọ: 2.45
Nrụgide Steam: 0.0 ± 1.1 mmHg na 25 Celsius
Ndekọ ntụgharị: 1.612
Ụgwọ nke ụlọ ọrụ Jiangsu Yongjian Pharmaceutical Technology Co., Ltd.
Jiangsu Yongjian Pharmaceutical Technology Co., Ltd., guzosie ike na March 2012, bụ a elu-tech Enterprise integrating R & D, mmepụta na ahịa.A na-etinyekarị aka na mmepụta, nhazi na mmepụta usoro mmepụta nke ihe ndị na-arụ ọrụ nke ngwaahịa ndị sitere n'okike, ihe ntụaka ọgwụ ndị China omenala na adịghị ọcha ọgwụ.Ụlọ ọrụ dị na China Pharmaceutical City, Taizhou City, Jiangsu Province, gụnyere 5000 square mita mmepụta isi na 2000 square mita R & D isi.Ọ na-eje ozi bụ isi ụlọ ọrụ nyocha sayensị, mahadum na ụlọ ọrụ mmepụta ihe decoction n'ofe mba ahụ.
Ka ọ dị ugbu a, anyị na-emepụta ihe karịrị 1500 iche iche nke eke compound reagents, na tụnyere na calibrated karịa 300 ụdị akwụkwọ ntụaka, nke nwere ike n'ụzọ zuru ezu izute kwa ụbọchị nnyocha mkpa nke isi sayensị nnyocha institutes, mahadum laboratories na decoction iberibe mmepụta ụlọ ọrụ.
Dabere na ụkpụrụ nke ezi okwukwe, ụlọ ọrụ na-atụ anya iji ezi obi na-akwado ndị ahịa anyị.Ebumnobi anyị bụ iji kwalite ọgwụ ọdịnala ndị China.
Uru azụmahịa oke nke ụlọ ọrụ
1. R & D, mmepụta na ire nke ihe ntụaka kemịkalụ nke ọgwụ ndị China omenala;
2. Ogige monomer ọgwụ ndị China ahaziri ahaziri dị ka njirimara ndị ahịa si dị
3. Nnyocha na ụkpụrụ dị mma na usoro mmepe nke ọgwụ ndị China omenala (osisi) wepụ
4. Teknụzụ imekọ ihe ọnụ, ịnyefe na nchọpụta ọgwụ ọhụrụ na mmepe.
