3-Hydroxy-9,10-dimethoxyptercarpan,Methylnissolin
Isticmaalka Methylnissolin
Methylnisolin (astrapterocarpan) ayaa ka go'an Astragalus membranaceus waxayna joojin kartaa kororka unugyada ee ay keento factor koritaanka platelet-derived factor (PDGF) - BB, oo leh IC50 ee 10 μM. 2) mitogen activated protein (map) kinase ay keentay PDGF-BB.Methylnisolin waxay joojisaa kororka PDGF-BB ee unugyada murqaha siman ee xididdada xididada iyadoo la joojinayo ERK1/2 MAP kinase cascade.
Magaca Methylnissolin
Magaca Ingiriisiga:
(-)-6aR,11aR-dihydro-3-hydroxy-9,10-dimethoxy-6H-benzofuro[3,2-c] [1]-benzopyran
Magaca Shiinaha: 3-hydroxy-9,10-dimethoxy sandalwood cas |Astragalus casaan
sandalwood |(6aR, 11ar) - 3-hydroxy-9,10-dimethoxy sandalwood cas
Dhaqdhaqaaqa noole ee Methylnissolin
Sharaxaad: methylnisolin (astrapterocarpan) ayaa ka go'an Astragalus membranaceus
waxayna joojin kartaa kororka unugga ee ay keento xuubka koritaanka platelet-derived (PDGF) - BB.
IC50 waa 10 μM. Methylnisolin waxay joojisaa fosforyaalka calaamadaha unugga ka baxsan
kinase nidaamsan 1/2 (eric1/2) borotiinka firfircoon ee mitogen (map) kinase ay keentay
PDGF-BB.Methylnisolin waxay xakameysaa faafinta PDGF-BB ee xididdada dhiigga oo siman
Unugyada murqaha iyagoo joojinaya ERK1/2 MAP kinase cascade.
Qaybaha la xidhiidha: goobta cilmi-baarista > > Cudurrada wadnaha iyo xididdada
Jidka signalka > > borotiinka tyrosine kinase>> PDGFR
Jidka calaamadda>> Waddada calaamadda MAPK / ERK>> ERK
dariiqa calaamadaynta>> unugyada asliga ah iyo jidka Wnt>> ERK
Masiibo:PDGFR:10 μM (IC50)
ERK1
ERK2
Tixraac:[1].Ohkawara S, iyo al.Astrapterocarpan oo ka go'doonsan Astragalus membranaceus waxay joojisaa kororka unugyada muruqyada siman ee xididdada dhiigga.Eur J Farmashiyaha.2005 Nof 21;525 (1-3): 41-7.
Astaamaha physicochemical ee Methylnissolin
Cufnaanta: 1.3 ± 0.1 g / cm3
Barta karkarinta: 428.9 ± 45.0 ° C at 760 mmHg
Qaacidada molecular: c17h16o5
Miisaanka Molecular: 300.306
Barta Tooshka ah: 213.2 ± 28.7 ° C
Tirada saxda ah: 300.099762
PSA:57.15000
LogP:2.45
Cadaadiska Uumiga: 0.0 ± 1.1 mmHg at 25 ° C
Tusmada dib-u-celinta: 1.612
Jiangsu Yongjian Pharmaceutical Technology Co., Ltd.
Jiangsu Yongjian Pharmaceutical Technology Co., Ltd., oo la aasaasay bishii Maarso 2012, waa shirkad farsamo sare ah oo isku dhafan R & D, wax soo saarka iyo iibinta.Waxay inta badan ku hawlan tahay wax soo saarka, habaynta iyo horumarinta habka wax soo saarka ee qaybaha firfircoon ee alaabta dabiiciga ah, alaabta tixraaca daawada dhaqameed ee Shiinaha iyo wasakhda daroogada.Shirkaddu waxay ku taal Shiinaha Pharmaceutical City, Taizhou City, Gobolka Jiangsu, oo ay ku jiraan 5000 mitir oo laba jibbaaran saldhigga wax soo saarka iyo 2000 mitir oo laba jibbaaran R & D.Waxay inta badan u adeegtaa machadyada cilmi-baarista sayniska ee waaweyn, jaamacadaha iyo shirkadaha wax soo saarka goos gooska ee dalka oo dhan.
Ilaa hadda, waxaan soo saarnay in ka badan 1500 nooc oo reagents xarunta dabiiciga ah, iyo barbar dhig iyo calibrated in ka badan 300 nooc oo qalabka tixraaca, kaas oo si buuxda u buuxin kara baahida kormeerka maalinlaha ah ee machadyada cilmi sayniska waaweyn, shaybaarada jaamacadda iyo qaybaha decoction shirkadaha wax soo saarka.
Iyada oo ku saleysan mabda'a niyad-wanaagga, shirkaddu waxay rajaynaysaa inay si daacad ah ula shaqeyso macaamiisheena.Hadafkayagu waa in aan u adeegno casriyaynta dawo dhaqameedka Shiinaha.
Baaxadda Ganacsiga Faa'iidada leh ee Shirkadda
1. R & D, wax soo saarka iyo iibinta alaabta tixraaca kiimikada ee daawada dhaqameed ee Shiinaha;
2. Iskudhisyada monomer ee daawada dhaqameed ee Shiineeska ah ee la habeeyey iyadoo loo eegayo sifooyinka macaamiisha
3. Cilmi-baadhis ku saabsan heerka tayada iyo horumarinta habka ee daawada dhaqameed ee Shiinaha (geedka).
4. Iskaashiga tignoolajiyada, wareejinta iyo cilmi baarista iyo horumarinta daroogada cusub.
