Ibicuruzwa

Ibisobanuro:monoammonium glycyrrhizinate hydrate ifite ibikorwa bya farumasi nka anti-inflammatory, anti allergic, ibisebe byo mu nda na hepatite.

Ibyiciro bifitanye isano:
inzira y'ibimenyetso >> izindi >> izindi
Umwanya wubushakashatsi >> gutwika / ubudahangarwa

Mu Kwiga Vivo:ubwiyongere bwibipimo byibihaha w / D byagabanutse cyane nubuyobozi bwa dosiye ndende kandi yo hagati ya mag (10 na 30 mg / kg).Kwitegura hamwe na mag (10 na 30 mg / kg) byagabanije neza TNF- α Na IL-1 β Igisekuru cya.Mag (10,30 mg / kg) yagabanije cyane NF ugereranije na LPS- κ Bp65 imvugo ya poroteyine.Ibinyuranye, LPS yagabanutse cyane nagereranije nitsinda rishinzwe kugenzura κ B- α Imvugo ya poroteyine, mugihe mag (10 na 30 mg / kg) yiyongereye cyane I κ B- α Imvugo [1].Ugereranije nitsinda rya RIF na INH, ubuvuzi buke bwa MAG bwagabanutse cyane urugero rwa ast, alt, TBIL na TBA muminsi 14 na 21, byerekana ingaruka zo gukingira MAG kuri RIF - na INH -.Tera igikomere cy'umwijima.Itsinda rivura MAG ryongereye umwijima GSH kurwego rwiminsi 7, 14 na 21, kandi ryagabanutse cyane urwego rwa MDA muminsi 14 na 21 muri RIF na INH zavuwe nimbeba, byerekana ingaruka zo gukingira MAG muri RIF - na.INH yateye umwijima umwijima [2].

Ubushakashatsi ku nyamaswa:imbeba [1] muri ubu bushakashatsi, hakoreshejwe imbeba za BALB / c (umugabo, ibyumweru 6-8, 20-25g).Imbeba zagabanyijwemo amatsinda 5: itsinda rishinzwe kugenzura, itsinda rya LPS na LPS + monoammonium glycyrrhizinate (Mag: 3,10 na 30mg / kg).Buri tsinda ryarimo imbeba 8.Imbeba zatewe aneste hamwe no gutera intraperitoneal ya sodium ya pentobarbital (50 mg / kg).Imbeba zatewe mu buryo butemewe na mag (3, 10 na 30 mg / kg) mbere yo gukomeretsa cyane ibihaha.Nyuma yisaha 1, LPS (5 mg / kg) yatewe inshinge kugirango itere ibihaha bikabije.Imbeba zisanzwe zahawe PBS [1].Imbeba [2] yakoresheje imbeba za Wistar (180-220g).Imbeba zagabanyijwemo amatsinda 4: itsinda rishinzwe kugenzura, itsinda RIF na INH, itsinda rya MAG rito rito hamwe na MAG itsinda ryinshi, hamwe nimbeba 15 muri buri tsinda.Imbeba mu matsinda ya RIF na INH zahawe RIF (60mg / kg) na INH (60mg / kg) na gavage rimwe kumunsi;Imbeba zo mu itsinda rya MAG zabanjirijwe na MAG ku kigero cya 45 cyangwa 90 mg / kg, naho RIF (60 mg / kg) na INH (60 mg / kg) bahabwa amasaha 3 nyuma y'ubuyobozi bwa MAG;Imbeba zo mu itsinda zishinzwe kugenzura zavuwe hamwe na saline isanzwe.Mu rwego rwo gusuzuma ingaruka z’ibiyobyabwenge, imbeba muri buri tsinda zishwe nyuma yiminsi 7, 14 na 21 nyuma yubuyobozi [2].

Reba:1].Huang X, n'abandi.Ingaruka zo Kurwanya Indwara ya Monoammonium Glycyrrhizinate kuri Lipopolysaccharide-Yatewe no gukomeretsa ibihaha bikabije mu mbeba binyuze mu kugenzura inzira ya kirimbuzi-Kappa B Inzira yerekana inzira.Ibimenyetso Bishingiye Kwuzuza Ubundi Med.2015; 2015: 272474.
[2].Zhou L, n'abandi.Monoammonium glycyrrhizinate irinda rifampicin- na isoniazid iterwa na hepatotoxicity ikoresheje kugenzura imiterere yabatwara Mrp2, Ntcp, na Oatp1a4 mu mwijima.Pharm Biol.2016; 54 (6): 931-7.