Cov khoom

Nqe lus piav qhia:monoammonium glycyrrhizinate hydrate muaj cov tshuaj siv tshuaj xws li tshuaj tiv thaiv kab mob, tiv thaiv kev tsis haum, tiv thaiv kab mob plab thiab tiv thaiv kab mob siab.

Cov qeb ntsig txog:
teeb liab txoj kev > > lwm yam > > lwm yam
Kev tshawb fawb teb >> mob / tiv thaiv kab mob

Hauv Vivo Study:Qhov nce ntawm lub ntsws w / D qhov hnyav piv tau txo qis los ntawm kev tswj hwm cov koob tshuaj siab thiab nruab nrab ntawm mag (10 thiab 30 mg / kg).Pretreatment nrog mag (10 thiab 30 mg / kg) zoo txo ​​TNF- α Thiab IL-1 β tiam ntawm.Mag (10,30 mg / kg) txo qis NF piv nrog LPS- κ Bp65 protein qhia.Nyob rau hauv sib piv, LPS ho txo ​​kuv piv nrog cov tswj pawg κ B- α Protein qhia, thaum mag (10 thiab 30 mg / kg) ho nce kuv κ B- α Qhia [1].Piv nrog cov pab pawg RIF thiab INH, kev kho mob tsawg thiab koob tshuaj MAG tau txo qis ast, alt, TBIL thiab TBA qib ntawm 14 thiab 21 hnub, qhia txog kev tiv thaiv ntawm MAG ntawm RIF - thiab INH -.Ua rau lub siab raug mob.MAG kho pab pawg tau nce siab GSH qib ntawm 7, 14 thiab 21 hnub, thiab txo qis MDA theem ntawm 14 thiab 21 hnub hauv RIF thiab INH kho nas, qhia txog kev tiv thaiv ntawm MAG hauv RIF - thiab.INH ua rau lub siab raug mob [2].

Kev sim tsiaj:nas [1] hauv txoj kev tshawb no, BALB / c nas (txiv neej, 6-8 lub lis piam, 20-25g) tau siv.Cov nas tau muab faib ua 5 pawg: pawg tswj hwm, LPS pawg thiab LPS + monoammonium glycyrrhizinate (Mag: 3,10 thiab 30mg / kg).Txhua pawg muaj 8 nas.Cov nas tau muab tshuaj loog nrog kev txhaj tshuaj intraperitoneal ntawm pentobarbital sodium (50 mg / kg).Cov nas tau txhaj tshuaj intraperitoneally nrog mag (3, 10 thiab 30 mg / kg) ua ntej ua rau mob ntsws mob.Tom qab 1 teev, LPS (5 mg / kg) tau txhaj tshuaj intracheal kom ua rau mob ntsws mob.Cov nas ib txwm tau muab PBS [1].Cov nas [2] siv txiv neej Wistar nas (180-220g).Cov nas tau muab faib ua 4 pawg: pawg tswj hwm, RIF thiab INH pawg, MAG pawg qis thiab MAG cov koob tshuaj siab, nrog 15 nas nyob hauv txhua pab.Cov nas tsuag hauv RIF thiab INH pawg tau muab RIF (60mg / kg) thiab INH (60mg / kg) los ntawm gavage ib hnub ib zaug;Cov nas tsuag hauv MAG pawg tau pretreated nrog MAG ntawm koob tshuaj 45 lossis 90 mg / kg, thiab RIF (60 mg / kg) thiab INH (60 mg / kg) tau muab 3 teev tom qab kev tswj hwm MAG;Cov nas nyob hauv pawg tswj hwm tau kho nrog cov ntsev ib txwm.Txhawm rau ntsuas cov txiaj ntsig zoo ntawm cov tshuaj, cov nas hauv txhua pab pawg raug tua 7, 14 thiab 21 hnub tom qab tswj hwm [2].

Siv:1].Huang X, et al.Anti-Inflammatory Effects of Monoammonium Glycyrrhizinate on Lipopolysaccharide-Induced Acute Lung Injury in Nice through Regulating Nuclear Factor-Kappa B Signaling Pathway.Evid Based Complement Alternat Med.Xyoo 2015; 2015: 272474.
[2].Zhou L, et al.Monoammonium glycyrrhizinate tiv thaiv rifampicin- thiab isoniazid-induced hepatotoxicity los ntawm kev tswj cov kev qhia ntawm transporter Mrp2, Ntcp, thiab Oatp1a4 hauv siab.Pharm Biol.2016; 54(6:931-7.