Zogulitsa

Kufotokozera:monoammonium glycyrrhizinate hydrate ali ndi ntchito za pharmacological monga odana ndi yotupa, anti matupi awo sagwirizana, anti gastric ulcer ndi anti hepatitis.

Magulu ofananira:
chizindikiro njira>> zina>> zina
Kafukufuku>> kutupa / chitetezo chokwanira

Mu Phunziro la Vivo:kuchuluka kwa mapapu w / D kulemera kwa chiŵerengero kunachepetsedwa kwambiri ndi makonzedwe apamwamba ndi apakati Mlingo wa mag (10 ndi 30 mg / kg).Kukonzekera ndi mag (10 ndi 30 mg / kg) kumachepetsa bwino TNF- α Ndi IL-1 β Generation ya.Mag (10,30 mg / kg) adachepetsa kwambiri NF poyerekeza ndi LPS- κ Bp65 mapuloteni.Mosiyana ndi zimenezi, LPS inachepetsa kwambiri ine poyerekeza ndi gulu lolamulira κ B- α Mawonetseredwe a mapuloteni, pamene mag (10 ndi 30 mg / kg) anawonjezera kwambiri I κ B- α Kufotokozera [1].Poyerekeza ndi magulu a RIF ndi INH, mankhwala ochepetsetsa komanso apamwamba a MAG amachepetsa kwambiri ast, alt, TBIL ndi TBA mlingo pa 14 ndi masiku 21, kusonyeza chitetezo cha MAG pa RIF - ndi INH -.Limbikitsani kuwonongeka kwa chiwindi.Gulu la mankhwala a MAG linawonjezera GSH mlingo wa chiwindi pa 7, 14 ndi 21 masiku, ndipo inachepetsa kwambiri mlingo wa MDA pa 14 ndi 21 masiku mu RIF ndi INH amachitira makoswe, kusonyeza zotsatira zotetezera MAG mu RIF - ndi.INH idapangitsa kuvulala kwachiwindi [2].

Kuyesera kwa Zinyama:mbewa [1] mu phunziro ili, BALB / c mbewa (amuna, masabata a 6-8, 20-25g) anagwiritsidwa ntchito.Mbewa zinagawidwa mwachisawawa m'magulu a 5: gulu lolamulira, gulu la LPS ndi LPS + monoammonium glycyrrhizinate (Mag: 3,10 ndi 30mg / kg).Gulu lililonse linali ndi mbewa zisanu ndi zitatu.Mbewa zinagwidwa ndi jakisoni wa intraperitoneal wa pentobarbital sodium (50 mg / kg).Mbewa zinabayidwa intraperitoneally ndi mag (3, 10 ndi 30 mg / kg) asanapweteke kwambiri m'mapapo.Pambuyo pa ola la 1, LPS (5 mg / kg) idabayidwa intracheal kuti ipweteke kwambiri m'mapapo.Makoswe wamba anapatsidwa PBS [1].Makoswe [2] ankagwiritsa ntchito makoswe aamuna a Wistar (180-220g).Makoswewa adagawidwa mwachisawawa m'magulu a 4: gulu lolamulira, gulu la RIF ndi INH, gulu la MAG otsika ndi gulu la MAG apamwamba, ndi makoswe a 15 pagulu lililonse.Makoswe m'magulu a RIF ndi INH adapatsidwa RIF (60mg / kg) ndi INH (60mg / kg) ndi gavage kamodzi patsiku;Makoswe omwe ali m'gulu la MAG adakonzedweratu ndi MAG pa mlingo wa 45 kapena 90 mg / kg, ndi RIF (60 mg / kg) ndi INH (60 mg / kg) anapatsidwa maola a 3 pambuyo pa kayendetsedwe ka MAG;Makoswe omwe ali m'gulu lolamulira amathandizidwa ndi saline wamba.Pofuna kuyesa mphamvu ya mankhwalawa, makoswe mu gulu lirilonse anaphedwa 7, 14 ndi 21 patatha masiku otsogolera [2].

Zolozera:1].Huang X, et al.Anti-Inflammatory Effects of Monoammonium Glycyrrhizinate pa Lipopolysaccharide-Induced Acute Lung Injury in Mice through Regulating Nuclear Factor-Kappa B Signaling Pathway.Evid Based Complement Alternat Med.2015;2015:272474.
[2].Zhou L, ndi al.Monoammonium glycyrrhizinate imateteza rifampicin- ndi isoniazid-induced hepatotoxicity kudzera pakuwongolera kafotokozedwe ka transporter Mrp2, Ntcp, ndi Oatp1a4 mu chiwindi.Zotsatira Pharm Biol.2016;54(6):931-7.