Fraxin;Pavin;Fraxoside;Fraxetol- 8-glucoside CAS No.524-30-1
Zambiri Zofunikira
Nambala ya CAS:524-30-1 [1]
EINECS No.:208-355-5
Molecular formula:c16h18o10
Kulemera kwa Molecular:370.3081
Kapangidwe ka Molecular:(Chithunzi 1)
Katundu:Makristalo opepuka achikasu acicular kapena flake crystal.
Kachulukidwe:1.634g/cm3
Malo Owiritsa:722.2 ° C pa 760 mmHg
Pophulikira:267 ° C
Steam Pressure:6.87e-22mmhg pa 25 ° C
Bioactivity ya Fraxin
Kufotokozera:Fraxin akhoza kupatulidwa ku Acer tegmentosum, F. ornus ndi a.hippocastanum.Ndi glycoside wa fraxine [1] ndipo ali ndi antioxidant, anti-inflammatory and anti metastasis activities.Fraxin amawonetsa antioxidant ntchito poletsa cyclic adenylate phosphodiesterase [2].
Zolinga:cyclo AMP phosphodiesterase enzyme [2]
Phunziro la In Vitro:Fraxin (100 μ M) Ilibe cytotoxicity ku maselo a Hep G2.Fraxin pamagulu osakhala a cytotoxic amachepetsa kwambiri t-BHP yopanga ROS m'njira yodalira mlingo [1].Fraxin (0.5 mm) imatha kuwononga ma radicals aulere pamlingo waukulu ndipo imakhala ndi cytoprotective effect pa H2O2 mediated oxidative stress [2].
Maphunziro a vivo:Fraxin (50 mg / kg, PO) adatsekereza kwambiri CCl4 kukwera kwa ALT ndi AST.Fraxin (10 ndi 50 mg / kg, PO) adachepetsa kwambiri milingo ya GSSG (1.7 ± 0.3 ndi 1.5 ± 0.2 nm / g chiwindi, motsatana) poyerekeza ndi milingo ya GSSG mu gulu lothandizidwa ndi CCl4
Zolozera:.Fraxin (50 mg/kg, po) imalepheretsa kwambiri kukwera kwa CCl4 kwa ALT ndi AST.Fraxin (10 ndi 50 mg/kg, po) amachepetsa kwambiri milingo ya GSSG (1.7±0.3 ndi 1.5±0.2 nM/g chiwindi, motsatana) poyerekeza ndi magulu a GSSG a gulu lothandizidwa ndi CCl4 [1].
[2].Whang WK, et al.Zinthu zachilengedwe, fraxin ndi mankhwala ogwirizana ndi fraxin amateteza ma cell kupsinjika kwa okosijeni.Exp Mol Med.2005 Oct 31;37(5):436-46.
