Fraxin;Paviin;Fraxoside;Fraxetol-8-glucoside CAS No.524-30-1
Macluumaadka Muhiimka ah
Lambarka CAS:524-30-1 [1]
Lambarka EINECS:208-355-5
Qaanuunka molecular:c16h18o10
Miisaanka Molecular:370.3081
Qaab-dhismeedka Molecular:(Jaantuska 1)
Guryaha:crystal acicular huruud khafiif ah ama crystal flake.
Cufnaanta:1.634g/cm3
Barta Karkari:722.2 ° C at 760 mmHg
Barta Tooshka ah:267 ° C
Cadaadiska Uumiga:6.87e-22mmhg at 25 ° C
Bioactivity ee Fraxin
Sharaxaad:Fraxin waa laga go'doomin karaa Acer tegmentosum, F. ornus iyo a.hippocastanum.Waa glycoside of fraxine [1] waxayna leedahay antioxidant, anti-bararka iyo hawlaha ka hortagga metastasis.Fraxin waxay soo bandhigtaa firfircoonida antioxidant-ka iyadoo la xakameynayo adenylate phosphodiesterase cyclic [2].
Bartilmaameedka:cyclo AMP phosphodiesterase enzyme [2]
Barashada Vitro dhexdeeda:Fraxin (100 μM) kuma laha cytotoxicity unugyada Hep G2.Fraxin marka la eego uruurinta cytotoxic-ka aan si weyn hoos ugu dhicin t-BHP waxay keentay soosaarka ROS qaab ku-tiirsanaan [1].Fraxin (0.5 mm) waxay ka takhalusi kartaa xagjirnimada xorta ah ee xoogga badan waxayna leedahay saameyn cytoprotective ah oo ku saabsan H2O2 diiqada oksaydhka ee dhexdhexaadka ah [2].
In vivo waxbarashada:Fraxin (50 mg / kg, PO) ayaa si weyn u xannibay kor u qaadista CCl4 ee ALT iyo AST.Fraxin (10 iyo 50 mg / kg, PO) ayaa si weyn hoos ugu dhacay heerarka GSSG (1.7 ± 0.3 iyo 1.5 ± 0.2 nm / g beerka, siday u kala horreeyaan) marka la barbar dhigo heerarka GSSG ee kooxda la daweeyay CCl4
Tixraac:.Fraxin (50 mg/kg, po) waxay si weyn u xannibaysaa kor u kaca ay CCl4 keentay ee ALT iyo AST.Fraxin (10 iyo 50 mg / kg, po) waxay si weyn u yaraynaysaa heerarka GSSG (1.7 ± 0.3 iyo 1.5 ± 0.2 nM / g beerka, siday u kala horreeyaan) marka la barbardhigo heerarka GSSG ee kooxda CCl4-daaweeyay [1].
[2].Whang WK, iyo al.Iskudhisyada dabiiciga ah,fraxin iyo kiimikooyinka qaab dhismeedka la xidhiidha fraxin waxay unugyada ka ilaaliyaan diiqada oksaydhka.Exp Mol Med.2005 Oct 31;37(5):436-46.
