Fraxin;ePaviin;iFraxoside;Fraxetol- 8-glucoside CAS No.524-30-1
Ulwazi oluBalulekileyo
Inombolo yeCAS:524-30-1 [1]
Inombolo ye-EINECS:208-355-5
Ifomula yemolekyuli:c16h18o10
Ubunzima beMolekyuli:370.3081
Ulwakhiwo lweMolekyuli:(Umfanekiso 1)
Iinkcazelo ngeempawu:Ikristale yeacicular etyheli ekhanyayo okanye ikristale yeflake.
Ubuninzi:1.634g/cm3
Indawo yokuBilisa:722.2 ° C kwi-760 mmHg
Indawo yokuflasha:267°C
Uxinzelelo lomphunga:6.87e-22mmhg ku-25 ° C
I-Bioactivity yeFraxin
Inkcazo:I-Fraxin inokwahlulwa kwi-Acer tegmentosum, F. ornus kunye ne-a.ihippocastanum.Yi-glycoside ye-fraxine [1] kwaye ine-antioxidant, i-anti-inflammatory kunye ne-anti metastasis imisebenzi.UFraxin ubonisa umsebenzi we-antioxidant ngokuthintela i-cyclic adenylate phosphodiesterase [2].
Ekujoliswe kuko:icyclo AMP phosphodiesterase enzyme [2]
Isifundo se-In Vitro:I-Fraxin (100 μ M) Ayinayo i-cytotoxicity kwiiseli ze-Hep G2.I-Fraxin ekugxininiseni okungeyona i-cytotoxic yanciphisa kakhulu i-t-BHP eyenza imveliso ye-ROS ngendlela exhomekeke kwidosi [1].I-Fraxin (i-0.5 mm) inokukhupha i-radicals yamahhala ekugxininiseni okuphezulu kwaye ibe nefuthe le-cytoprotective kwi-H2O2 yoxinzelelo oludibeneyo lwe-oxidative [2].
Isifundo se-vivo:I-Fraxin (50 mg / kg, PO) ivalwe kakhulu i-CCl4 eyenza ukuphakama kwe-ALT kunye ne-AST.I-Fraxin (i-10 kunye ne-50 mg / kg, i-PO) yanciphisa kakhulu amanqanaba e-GSSG (1.7 ± 0.3 kunye ne-1.5 ± 0.2 nm / g isibindi, ngokulandelanayo) xa kuthelekiswa namanqanaba e-GSSG kwiqela eliphathwayo le-CCl4
Isalathiso:.I-Fraxin (50 mg / kg, po) ivimba kakhulu i-CCl4-induced elevation ye-ALT kunye ne-AST.I-Fraxin (i-10 kunye ne-50 mg / kg, i-po) iyanciphisa kakhulu amanqanaba e-GSSG (1.7±0.3 kunye ne-1.5± 0.2 nM / g isibindi, ngokulandelanayo) xa kuthelekiswa namanqanaba e-GSSG yeqela eliphathwa nge-CCl4 [1].
[2].Whang WK, et al.Iikhompawundi zendalo, i-fraxin kunye neekhemikhali ezinxulumene ne-fraxin zikhusela iiseli kuxinzelelo lwe-oxidative.Exp Mol Med.2005 Okt 31;37(5):436-46.
