Imikhiqizo

Incazelo:i-monoammonium glycyrrhizinate hydrate inemisebenzi yezemithi efana ne-anti-inflammatory, anti-allergic, anti-gastric ulcer kanye ne-anti-hepatitis.

Izigaba ezihlobene:
indlela yesignali > > enye > > enye
Inkambu yocwaningo > > ukuvuvukala / ukungatheleleki

Esifundweni Se-Vivo:ukwanda kwesilinganiso sesisindo samaphaphu w / D kwehliswe kakhulu ngokuphathwa kwemithamo ephezulu nephakathi ye-mag (10 kanye ne-30 mg / kg).Ukwelashwa kwangaphambili nge-mag (10 kanye ne-30 mg / kg) kunciphise ngempumelelo i-TNF- α Kanye ne-IL-1 β Generation of.I-Mag (10,30 mg / kg) inciphise kakhulu i-NF uma iqhathaniswa ne-LPS- κ Bp65 amaprotheni expression.Ngokuphambene, i-LPS inciphise kakhulu ngiqhathanisa neqembu lokulawula κ B- α Inkulumo yamaprotheni, kuyilapho i-mag (10 kanye ne-30 mg / kg) yanda kakhulu I κ B- α Expression [1].Uma kuqhathaniswa namaqembu e-RIF ne-INH, umthamo ophansi kanye nomthamo ophezulu we-MAG ukwelashwa kwehliswe kakhulu amazinga e-ast, alt, TBIL kanye ne-TBA ezinsukwini ezingu-14 nezi-21, okubonisa umphumela wokuvikela we-MAG ku-RIF - ne-INH -.Dala ukulimala kwesibindi.Iqembu lokwelapha le-MAG lenyuke izinga le-GSH lesibindi ku-7, i-14 nezinsuku ze-21, futhi lehla kakhulu izinga le-MDA ku-14 nezinsuku ze-21 ku-RIF kanye ne-INH ephathwa ngamagundane, okubonisa umphumela wokuvikela we-MAG ku-RIF - kanye.I-INH idale ukulimala kwesibindi [2].

Ukuhlolwa kwezilwane:amagundane [1] kulolu cwaningo, amagundane e-BALB / c (owesilisa, amasonto angu-6-8 ubudala, i-20-25g) asetshenzisiwe.Amagundane ahlukaniswe ngokungahleliwe abe amaqembu e-5: iqembu lokulawula, iqembu le-LPS ne-LPS + monoammonium glycyrrhizinate (Mag: 3,10 kanye ne-30mg / kg).Iqembu ngalinye beliqukethe amagundane angu-8.Amagundane abulawa izinzwa ngomjovo we-intraperitoneal we-pentobarbital sodium (50 mg / kg).Amagundane ajovwe nge-intraperitoneally nge-mag (3, 10 kanye ne-30 mg / kg) ngaphambi kokulimaza amaphaphu abukhali.Ngemuva kwehora elingu-1, i-LPS (5 mg/kg) yajovwa nge-intracheal ukuze idale ukulimala okukhulu kwamaphaphu.Amagundane avamile anikezwe i-PBS [1].Amagundane [2] asebenzisa amagundane angama-Wistar (180-220g).Amagundane ahlukaniswe ngokungahleliwe abe amaqembu e-4: iqembu lokulawula, iqembu le-RIF ne-INH, iqembu le-MAG eliphansi le-dose kanye neqembu le-MAG ephezulu, elinamagundane angu-15 eqenjini ngalinye.Amagundane kumaqembu e-RIF kanye ne-INH anikezwa i-RIF (60mg / kg) kanye ne-INH (60mg / kg) nge-gavage kanye ngosuku;Amagundane eqenjini le-MAG aphathwa ngaphambili nge-MAG ngethamo le-45 noma i-90 mg / kg, futhi i-RIF (60 mg / kg) ne-INH (60 mg / kg) yanikezwa amahora angu-3 ngemuva kokuphathwa kwe-MAG;Amagundane eqenjini lokulawula aphathwe nge-saline evamile.Ukuze kuhlolwe umphumela oguquguqukayo womuthi, amagundane eqenjini ngalinye abulawa 7, 14 kanye nezinsuku ezingu-21 ngemva kokuphathwa [2].

Ireferensi:1].U-Huang X, et al.Imithelela Eqeda Ukuvuvukala Ye-Monoammonium Glycyrrhizinate Ku-Lipopolysaccharide-Induced Acute Lung Injury Kumagundane Ngokulawula I-Nuclear Factor-Kappa B Signaling Pathway.I-Evid Based Complement Alternat Med.2015;2015:272474.
[2].UZhou L, et al.I-Monoammonium glycyrrhizinate ivikela i-hepatotoxicity eyenziwe yi-rifampicin ne-isoniazid ngokulawula ukubonakaliswa kwe-transporter uMrp2, Ntcp, ne-Oatp1a4 esibindi.I-Pharm Biol.2016;54(6):931-7.