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Aconitum Glycyrrhizinum

Description:

Nomen commune: Aconitum Glycyrrhizinum English Name: glycyrrhizicum acidum ammonium sal

CAS No.: 53956-04-0

Pondus hypotheticum: 839.96

Densitas: 1.43g/cm3

Fervens: 971.4 C ad 760mmhg

Formulae hypotheticae: C42H65NO16

Punctum liquescens: 971.4 C ad 760mmhg

Mico Point: 288.1 C


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Aconitum Glycyrrhizinatum

Monoammonium hydratum glycyrrhizinatum habet operationes pharmacologicas sicut anti-inflammatorium, anti allergicum, anti ulceris gastrici et anti hepatitis.

Nomen Of Aconitum Glycyrrhizinum

Nomen Sinica:
Aconitum Glycyrrhizinum

Nomen anglicum:
glycorrhizic acid ammoniaci salis

SeresAlias:
glycyrrhizic acid monoammonium hydratum |glycyrrhizic acid monoammonium hydratum |glycyrrhizic acid monoammonium sal |glycyrrhizic acid monoammonium sal |glycyrrhizicum acidum monoammonium sal hydratum |glycyrrhizicum acidum monoammoniacum

Aconitum tuberosum

Descriptio:monoammonium hydratum glycyrrhizinatum habet operationes pharmacologicas sicut anti-inflammatorium, anti allergicum, anti ulceris gastrici et anti hepatitis.

Genera cognata:
signum iter > > alius > > alius
Investigationes campi > ​​> inflammatio / immunitas

In Vivo Study:augmentum pulmonis w / D proportio ponderis signanter redacta erat administratione magni ac mediae doses mag- (10 et 30 mg / kg).Praetractatio cum mag (10 et 30 mg / kg) efficaciter reducta TNF- α et IL-1 β Generation of.Mag (10,30 mg / kg) signanter reducitur NF cum LPS- κ Bp65 cum expressione interdum.E contra, LPS signanter redactus comparavi cum globum κ B- α cum expressione interdum, cum mag (10 et 30 mg / kg) insigniter auctus I κ B- α elocutionis [1].Comparati cum RIF et INH coetuum, dose et alta curatione MAG curationis ast, alt, TBIL et TBA signanter reducta in 14 et 21 dies, significant effectum tutelae MAG in RIF et INH -.Inducere jecur injuria.MAG treatment coetus iecoris GSH augetur in gradu 7, 14 et 21 diebus, et signanter minuitur gradu MDA in 14 et 21 diebus in RIF et INH muribus tractatis, ostendens effectum tutelae MAG in RIF - et.INH INDUCTAE iecur iniuriae [2].

Animalia experimenta:mures [1] in hoc studio Balb/m mures (masculinum, 6-8 hebdomades, 20-25g) usi sunt.Mures passim in 5 circulos divisi sunt: ​​globus moderatus, coetus LPS et LPS + monoammonium glycyrrhizinatum (Mag: 3,10 et 30mg / kg).Utrique numero aureos 8 continebant.Mures anesthetizati cum injectione intraperitoneali sodium pentobarbitalis (50 mg / kg).Mures intraperitonealiter cum mag (3, 10 et 30 mg / kg) injecti sunt antequam injuriam pulmonis acuti inducunt.Post horam 1 , LPS ( 5 mg / kg ) injectum est intratracheum ut injuriam acutum pulmonem inducat.Mures normales sunt dati PBS [1].Mures [2] mas Wistar mures usi (180-220g).Mures passim in 4 circulos divisae sunt: ​​coetus control, RIF et INH coetus, MAG coetus humilis dosis, MAG coetus summus dosis, cum XV muribus in singulis.Mures in RIF et INH catervae datae sunt RIF (60mg / kg) et INH (60mg / kg) per gavagum semel in die;Mures in MAG coetus praelati sunt cum MAG dose 45 vel 90 mg / kg, et RIF (60 mg / kg) et INH (60 mg / kg) datae sunt 3 horis post MAG administrationem;Mures in globo dicione saline normali tractati sunt.Ad aestimandum effectum dynamicum venefici, mures in singulis gregibus interfecti sunt 7, 14 et 21 dies post administrationem [2].

Relatio:1].Huang X, et al.Anti-inflammatoriae effectus Monoammonium Glycyrrhizinatum in Lipopolysaccharide-inductum Laesio acuta pulmonis in Muribus per nuclei Factor-Kappa Regulans B signans Pathway.Evid Based Complement Alternat Med.2015;2015:272474.
[2].Zhou L, et al.Monoammonium glycyrrhizinatum tuetur rifampicin- et isoniazid-inducta hepatotoxicity per regulantem expressionem transportator Mrp2, Ntcp, et Oatp1a4 in hepate.Phorm Biol.2016, 54 (6): 931-7.

Physicochemical Properties of Aconitum Glycyrrhizinate

Densitas: 1.43g/cm

Fervens punctum: 971.4 C ad 760mmhg

Exustio Point: 209 C

Formulae hypotheticae: c42h65no16

Pondus hypotheticum: 839.96

Mico Point: 288.1 C

PSA:272.70000

LogP:0.32860

Species: album crystallinum pulveris

Index refractivus: 49 ° (C = 1.5, EtOH)

Repono Conditiones: obsignatas et reconditas in 2 C - 8 C

Stabilitas: si usus et repositus secundum speciem, non corrumpetur nec notum est reactionem periculosam

Aqua Solubilitas: in aqua leviter solubilis, lentissime solubilis in ethanolo anhydroso, in acetono fere solubilis, in solutionibus acidarum et alcali hydroxidis dilutis solvit.

Aconitum Glycyrrhizinum MSDS

Aconitum Glycyrrhizinum MSDS

1,1 productum identifier

Aconitum glycyrrhizinum est ex radice liquiritiae (licoricae)

Product nomen

1.2 aliis modis idem

Glycyrrhizin

3-O-(2-O- β- D-Glucopyranuronosyl- α- D-glucopyranuronosyl)-18 β- glycyrrhetinicum acidammonium salis

1.3 pertinet identified usus substantiarum vel mixtionum et idoneos usus

Solum ad investigationes scientificas proposita, non sicut medicamenta, familia medicamenta vel alia proposita.

Aconitum Glycyrrhizinum Salutis Information

Personalis armorum tutela: eyeshields;Gloves;typus N95 (US);type P1 (EN143) respirator filter

Periculo bona oneraria codice: UN 3077 9 / pgiii

Wgk Germania: 2

RTECS No.: lz6500000

Praeparatio Aconitum Glycyrrhizinatum

Depurari potest cum ethanolo acido ut materia rudis.

Aconitum glycyrrhizinum litterae

Dapibus HMGB1 sentit carcinoma coloniae cellae ad mortem cellulae agentibus pro-apoptoticis Urguet.

Int.J. Oncol.46(2), 667-76, (2014)

Dapibus HMGB1 multa munera habet in tumore biologiae et agere potest tum ut factor transcriptionis et sicut cytokinus.HMGB1 per cellam mortem liberatur et in studiis nostris superioribus demonstravimus...

TLR9 activum excitat excessum stimulatorii versuum inhibitoriarum motivirum quae in Trypanosomatid DNA habentur.

Glycyrrhizin secretionem HMGB1 reducit in lipopolysaccharide-activo RAW 264.7 cellulis et muribus endotoxemic ab inductione HO-1.

Int.Immunopharmacol.26, 112-8, (2015).

Alta mobilitas archa coetus 1 (HMGB1) nunc agnoscitur ut nuper mediatrix saepsis.Etsi glycyrrhizin nota erat inhibitor of HMGB1, nondum patet mechanismum subesse (s).Invenimus glyc...

Alias ​​Aconitum glycyrrhizinum

GLYCAMIL

Aconitumglycynhizinato

glycyrrhizicum acidum monoammonium sal

Ammonium glycyrrhizinum

MCD00167400

Glycyrrhizin Monoammonium Sal Hydrate

Acidum Glycyrrhizicum Monoammonium Sal Hydrate

glucopyranuronosyl-α-D glucopyranuronosyl-α-D-glucopyranosiduronicum 12-en-3-yl 2-O-β-D-acidi glucopyranuronosyl-α-D

GLYCYRRHIZICAMMONIUM

Magnasweet

ammoniatus

Monoammonium Glycyrrhizinum Hydrate

Glycyrrhizate monoammonium


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