I-Isoliquiritin Apioside
Ukusetshenziswa kwe-Isoliquiritin Apioside
I-Isoliquiritin apioside, ingxenye ehlukanisiwe ne-glycorrhizae radio rhome, inciphise kakhulu ukwanda okwenziwe i-PMA kumsebenzi we-MMP9 futhi ivimbele i-PMA eyenzelwe i-MAPK kanye nokusebenza kwe-NF- κ B.I-Isoliquitin apioside ivimbela ukuhlasela kanye ne-angiogenesis yamangqamuzana omdlavuza namaseli endothelial.
Igama le-Isoliquiritin Apioside
Igama lesiShayina:I-Isoliquiritin Apioside
Igama lesiNgisi:(E)-3- [4-[(2S,3R,4S,5S,6R)-3- [(2S,3R,4R)-3,4-dihydroxy-4-(hydroxymethyl)oxolan-2-yl] oxy-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]-1-(2,4-dihydroxyphenyl)prop-2-en-1-one
I-Bioactivity ye-Isoliquiritin Apioside
Incazelo:i-isoliquitin apioside, ingxenye ehlukanisiwe ne-glycorrhizae radio rhome, inciphise kakhulu ukwanda okwenziwe i-PMA kumsebenzi we-MMP9 futhi yavimbela i-PMA eyenzelwe i-MAPK kanye nokusebenza kwe-NF- κ B.I-Isoliquitin apioside ivimbela ukuhlasela kanye ne-angiogenesis yamangqamuzana omdlavuza namaseli endothelial.
OkuhlobeneCizigaba:umkhakha wocwaningo > > umdlavuza
Indlela yesiginali > > I-MAPK / indlela yesiginali ye-ERK > > p38 MAPK
Indlela yokusayina>> i-enzyme/protease>>MMP
Ithagethi:MMP9
I-NF-kB
p38 MAPK
Isifundo se-in vitro:I-isorlicin ingavimbela ngempumelelo umsebenzi we-gelation we-MMP-9 wamaseli e-HT1080 enziwe yi-PMA.I-Isoglycyrrhizin apigenin yehlisa ukwanda kokukhiqizwa kwe-MMP-9 kumaseli e-HT1080 ethonywe yi-PMA, inamandla okulwa nokumetastasis kanye ne-anti angiogenesis kumaseli e-tumor ayingozi namaseli e-endothelial, futhi ayinayo i-cytotoxicity [1].
Ireferensi:[1].UKim A1, et al.I-Isoliquiritin Apioside Suppresses in vitro Invasiveness and Angiogenesis of Cancer Cells and Endothelial Cells.Front Pharmacol.2018 Dec 10;9:1455.
Izakhiwo ze-Physicochemical of Isoliquiritin Apioside
Ukuminyana: 1.6 ± 0.1 g / cm3
Indawo yokubilisa: 901.0 ± 65.0 ° C ku-760 mmHg
Ifomula yemolekyuli: c26h30o13
Isisindo se-molecule: 550.509
Iphoyinti elikhanyayo: 301.9 ± 27.8 ° C
Isisindo esinembile: 550.168640
I-PSA: 215.83000
I-logP:1.96
Umfutho we-steam: 0.0 ± 0.3 mmHg ku-25 ° C
Inkomba ye-refractive: 1.709
Isibizo sesiNgisi se-Isoliquiritin Apioside
2-Propen-1-one,1-(2,4-dihydroxyphenyl)-3-[4-[[2-O-[(2S,3R,4R))-tetrahydro-3,4-dihydroxy-4-(hydroxymethyl )-2-furanyl]-β-D-glucopyranosyl]oxy]phenyl]-, (2E)-
3-[(1E)-3-(2,4-Dihydroxyphenyl)-3-oxo-1-propen-1-yl]phenyl 2-O-[(2S,3R,4R)-3,4-dihydroxy-4 -(hydroxymethyl)tetrahydro-2-furanyl]-β-D-glucopyranoside
I-Neolicuroside