Naringenin-7-O-neohesperidoside;Naringin;Isonaringenin CAS No.: 10236-47-2
Lus Taw Qhia
Lub npe Askiv:naringin
Kev siv:nws tuaj yeem siv los ua zaub mov ntxiv, feem ntau yog rau cov pos hniav qab zib, dej txias, thiab lwm yam.
Physicochemical zog:Naringin yog ib qho complex ntawm qabzib, rhamnose thiab naringin.Nws yog dawb mus rau lub teeb daj crystalline hmoov.Feem ntau, nws muaj 6 ~ 8 siv lead ua dej nrog lub melting point ntawm 83 ℃.Ua kom qhuav kom qhov hnyav tas li ntawm 110 ℃ kom tau cov khoom siv lead ua muaj 2 cov dej siv lead ua, nrog rau qhov chaw melting ntawm 171 ℃.Naringin muaj ib tug heev iab saj, thiab aqueous tov nrog ib tug concentration ntawm 20mg / kg tseem muaj ib tug iab saj.Me ntsis soluble hauv dej, yooj yim soluble hauv dej kub, ethanol, acetone thiab sov glacial acetic acid.Muaj phenolic hydroxyl pawg nyob rau hauv cov qauv, thiab nws cov aqueous tov yog weakly acidic.Cov khoom "citrus glucoside dihydrochalcone" tom qab hydrolysis thiab hydrogenation yog cov khoom qab zib, thiab qab zib yog ntau tshaj 150 npaug ntawm sucrose.
Numbering System
CAS Nr .: 10236-47-2
MDL No.: mfcd00149445
EINECS No.: 233-566-4
RTECS No.: qn6340000
PIB No.: 102012
Cov ntaub ntawv khoom ntiag tug
1. Cov cwj pwm: naringin yog ib qho complex ntawm qabzib, rhamnose thiab txiv kab ntxwv gametophyte.Nws yog dawb mus rau lub teeb daj crystalline hmoov.
2. Melting point (º C): 171
3. Refractive Performance index: -84
4. Kev sib hloov tshwj xeeb (º): - 91
5. Solubility: me ntsis soluble hauv dej, yooj yim soluble hauv dej kub, ethanol, acetone thiab sov glacial acetic acid.
Cov ntaub ntawv Toxicology
1. Txoj kev kuaj: plab kab noj hniav
Kev noj tshuaj: 2 mg / kg
Test object: nas nas
Hom toxicity: mob
Toxic teebmeem: cov ncauj lus kom ntxaws txog tshuaj lom thiab cov kev mob tshwm sim tsis tau tshaj tawm tshwj tsis yog rau lwm qhov txiaj ntsig ntawm kev ua kom tuag taus
2. Txoj kev kuaj: plab kab noj hniav
Kev noj tshuaj: 2 mg / kg
Test object: nas guinea npua
Hom toxicity: mob
Toxic teebmeem: cov ncauj lus kom ntxaws txog tshuaj lom thiab cov kev mob tshwm sim tsis tau tshaj tawm tshwj tsis yog rau lwm qhov txiaj ntsig ntawm kev ua kom tuag taus
Cov ntaub ntawv ecological
Cov tshuaj no yuav ua rau muaj kev phom sij rau ib puag ncig, yog li kev saib xyuas tshwj xeeb yuav tsum tau them rau lub cev dej.
Molecular Structure Data
1. Molar refractive index: 135.63
2. Molar ntim (cm3 / mol): 347.8
3. Isotonic tshwj xeeb ntim (90.2k): 1103.4
4. Nto nro (dyne / cm): 101.2
5.Polarizability (10-24cm3): 53.76 [2]
Xam cov ntaub ntawv tshuaj
1. Tus nqi siv rau hydrophobic parameter xam (xlogp): - 0.5
2. Tus naj npawb ntawm cov nyiaj pub dawb hydrogen: 8
3. Tus naj npawb ntawm hydrogen bond receptors: 14
4. Number of rotatable chemical bonds: 6
5. Topological molecular polar nto cheeb tsam (TPSA): 225
6. Tus naj npawb ntawm cov atom hnyav: 41
7. Nto nqi: 0
8. :884
9. Tus naj npawb ntawm isotopic atoms: 0
10. Txiav txim seb tus naj npawb ntawm atomic stereocenters: 11
11. Tus naj npawb ntawm cov tsis paub meej atomic stereocenters: 0
12. Txiav txim seb tus naj npawb ntawm cov tshuaj stereocenters: 0
13. Number of indeterminate chemical bond stereocenters: 0
14. Number of covalent bond units: 1
Khoom thiab Stability
Yog siv thiab khaws cia raws li specifications, nws yuav tsis decompose.
Txoj kev khaws cia
Khoom noj khoom haus qib hnab yas yog them nrog kraft ntawv hnab rau ntim ntim.Khaws rau hauv qhov chaw txias thiab qhuav.
Lub hom phiaj
Grapefruit txiv hmab txiv ntoo yog nplua nuj nyob rau hauv naringin, uas yog hais txog 1%.Nws tsuas yog muaj nyob rau hauv tev, capsule thiab noob.Nws yog lub ntsiab lus iab hauv cov txiv hmab txiv ntoo.Naringin muaj txiaj ntsig zoo ntawm kev lag luam thiab tuaj yeem siv los ua cov khoom qab zib dihydrochalcone tshiab, nrog rau cov tshuaj tiv thaiv thiab kho cov kab mob plawv, kev ua xua thiab mob.
1. Nws tuaj yeem siv los ua cov khoom siv ntxiv, feem ntau yog rau cov pos hniav qab zib, dej txias, thiab lwm yam.
2. Nws tuaj yeem siv los ua cov khoom siv raw rau kev sib txuas ntawm cov khoom qab zib tshiab dihydronaringin chalcone thiab neohesperidin dihydrochalcone nrog siab qab zib, tsis muaj tshuaj lom thiab tsis muaj zog.
Txoj kev Extraction
Naringin yog yooj yim soluble nyob rau hauv cawv thiab alkali tov, thiab kuj yuav yaj nyob rau hauv dej kub.Raws li tus yam ntxwv no, naringin feem ntau yog muab rho tawm los ntawm txoj kev alkali thiab dej kub.Cov txheej txheem ntau lawm yog raws li nram no: Pomelo Peel → crushing → leaching nrog txiv qaub dej los yog dej kub → pom → txias thiab nag los nag → sib cais → ziab thiab crushing → tiav cov khoom.
Txoj Kev Kub Kub
Cov txheej txheem dej kub rho tawm yog raws li hauv qab no: tom qab pomelo tev yog crushed, ntxiv 3 ~ 4 zaug dej, kub thiab boil rau 30min, thiab nias kom tau cov filtrate.Cov kauj ruam no tuaj yeem rov ua dua 2 ~ 3 zaug.Tom qab cov filtrate yog concentrated rau 3 ~ 5 zaug, nws tseem yog (0 ~ 3 ℃) rau precipitate thiab crystallize, lim thiab sib cais, thiab precipitate yog cov khoom crude.Nws tuaj yeem ua kom zoo nrog cawv lossis dej kub.Txoj kev no muaj tsawg rov qab thiab lub sij hawm los nag ntev.Tsis ntev los no, Citrus Research Institute ntawm Suav Academy ntawm Agricultural Sciences tau txhim kho txoj kev, uas yog, cov extract yog kho nrog poov xab los yog pectinase, uas shortens lub sij hawm los nag thiab txhim kho cov yield thiab purity li ntawm 20% ~ 30%.Cov seem tev tawm tuaj yeem siv los rho tawm pectin.
Cov txheej txheem Alkali
Txoj kev alkali yog tsau cov tawv residue nyob rau hauv cov dej txiv qaub (pH12) rau 6 ~ 8h thiab nias nws kom tau cov filtrate.Muab cov lim dej tso rau hauv lub lauj kaub tais diav, nruab nrab nrog 1: 1 hydrochloric acid rau pH 4.1 ~ 4.4, kub rau 60 ~ 70 ℃, thiab ua kom sov rau 40 ~ 50min.Tom qab ntawd txias ntawm qhov kub qis kom precipitate naringin, sau cov precipitate, qhuav cov dej nrog centrifuge, muab tso rau hauv chav tsev kom qhuav, qhuav ntawm 70 ~ 80 ℃, zuaj thiab zom rau hauv cov hmoov zoo, uas yog cov khoom nyoos.Rov ua crystallization nrog cawv kub rau 2 ~ 3 zaug kom tau txais cov khoom ntshiab.
Txhim kho txheej txheem
Nrog rau txoj kev saum toj no, cov piam thaj, pectin, protein, pigment thiab lwm yam khoom nyob rau hauv pomelo tev nkag mus rau extraction tov tib lub sij hawm, ua rau cov khoom uas tsis muaj purity thiab multi-kauj ruam recrystallization rau purification.Yog li ntawd, lub sij hawm rho tawm yog ntev, cov txheej txheem yog complex, thiab cov kuab tshuaj, lub zog thiab tus nqi yog nce.Txhawm rau ua kom cov txheej txheem yooj yim dua, txhim kho cov purity ntawm cov khoom thiab txo tus nqi, ntau cov kev tshawb fawb tau ua rau cov txheej txheem rov qab los ntawm naringin.Li Yan et al.(1997) siv ultrafiltration kom paub meej naringin extract.Lub purity ntawm cov khoom tau los ntawm crystallization yuav nce los ntawm 75% ntawm cov tsoos alkali txoj kev mus rau 95%.Kev ua haujlwm ntawm ultrafiltration yog raws li nram no: siab 0.15 ~ 0.25MPa, circulating flux 180L / h, pH 9 ~ 10 thiab kub txog 50 ℃.Nyiv Itoo (1988) ua tiav purified naringin nrog macroporous adsorption resin diaion HP-20.Wu houjiu et al.(1997) kuj tau tshaj tawm tias ob peb lub teb chaws macroporous adsorption resins muaj qhov zoo adsorption thiab analytical zog rau naringin, uas yuav siv tau rau kev sib cais thiab purification ntawm naringin.Hauv cov ntsiab lus, tus sau tso rau hauv cov txheej txheem txhim kho hauv qab no.Daim ntawv qhia ntws yog raws li nram no: Pomelo Peel → crushing → dej kub extraction → pom → ultrafiltration → ultrafiltration permeate → resin adsorption → analytical solution → concentration → txias nag los nag → sib cais → txhiab ziab → khoom tiav.