Galangin CAS No. 548-83-4
ʻAno kino a me kemika
Alias:Gaoliang Curcumin;3,5,7-trihydroxyflavone,
inoa Pelekania:galangin,
inoa Pelekane:3,5,7-trihydroxyflavone;3,5,7-trihydroxy-2-phenylchromen-4-hoʻokahi
Hoʻokumu Molecular
1. Helu kuhikuhipuʻuone mola: 69.55
2. Ka nui molar (m3 / mol): 171.1
3. Ka nui kiko'ī isotonic (90.2k): 519.4
4. ʻO ka ʻili o ka ʻili (dyne / cm): 84.9
5. Polarizability (10-24cm3): 27.57
Kemika helu
1. Waiwai kuhikuhi no ka helu ʻana i ka hoʻohālikelike hydrophobic (xlogp): ʻAʻohe
2. Ka helu o nā mea hāʻawi paʻa hydrogen: 3
3. Ka helu o nā mea hoʻopaʻa paʻa hydrogen: 5
4. Ka helu o nā mea paʻa kemika hiki ke hoʻololi: 1
5. Ka helu o nā tautomer: 24
6. Topological molecular polarity ili 87
7. Ka helu o nā ʻātoma kaumaha: 20
8. Ka uku o ka ʻili: 0
9. Paʻakikī: 424
10. Ka helu o nā ʻātoma isotopic: 0
11. E hoʻoholo i ka heluna o nā stereocenter atomika: 0
12. Ka helu o nā stereocenter atomika maopopo ʻole: 0
13. E hoʻoholo i ka heluna o nā stereocenters paʻa kemika: 0
14. Ka helu o nā stereocenters paʻa kemika paʻa ʻole: 0
15. Ka helu o nā pūʻulu pili covalent: 1
Hana lāʻau lapaʻau
Hiki i ka Galangin ke hoʻololi iā Salmonella typhimurium TA98 a me TA100 a he hopena antiviral
Haʻawina In Vitro
Ua kāohi ʻo Galangin i ka catabolism o DMBA ma ke ʻano i hilinaʻi ʻia.Ua pale aku ʻo Galangin i ka hoʻokumu ʻana o DMBA-DNA adducts a pale i ka DMBA i hoʻokomo ʻia i ka ulu ʻana o ka cell ulu.I loko o nā keena paʻa a me nā microsomes i hoʻokaʻawale ʻia mai nā cell i mālama ʻia e DMBA, ua hoʻopuka ka galangin i ka hoʻopaʻa ʻana i ka nui o ka hana CYP1A1 i ana ʻia e ka hana ethoxypurine-o-deacetylase.Ua hōʻike ʻia ka ʻike ʻana o nā kinetics inhibition e ka pākuʻi pālua i ka galangin i keʻakeʻa i ka hana CYP1A1 ma ke ʻano hoʻokūkū ʻole.Ke alakaʻi nei ʻo Galangin i ka piʻi ʻana o ka pae CYP1A1 mRNA, e hōʻike ana he agonist paha ia o ka mea hoʻokipa hydrocarbon aromatic, akā ke kāohi nei i ka CYP1A1 mRNA (TCDD) i hoʻokomo ʻia e DMBA a i ʻole 2,3,5,7-tetrachlorodibenzo-p-dioxin.Hoʻopaʻa pū ʻo Galangin i ka DMBA a i ʻole TCDD i hoʻokomo ʻia i ka transcription o nā vectors reporter i loaʻa ka mea hoʻolaha CYP1A1 [1].ʻO ka lāʻau Galangin i kāohi i ka hoʻonui ʻana o ka cell a hoʻoulu i ka autophagy (130) μ M) A me ka apoptosis (370 μ M)。 ʻO ka mea nui, ʻo ka mālama ʻana i ka galangin i nā cell HepG2 ka hopena i (1) ka hōʻiliʻili ʻana o nā autophagosome, (2) piʻi i nā pae o ka microtubule pili i ke kaulahao māmā protein. 3, a me (3) hoʻonui i ka pākēneka o nā pūnaewele me nā vacuoles. Ua hoʻonui pū ʻia ka manaʻo P53. Ua hoʻemi ʻia ka autophagy i hoʻokomo ʻia e Galangin ma ke kāohi ʻana i ka p53 i loko o nā pūnaewele HepG2, a ua hoʻihoʻi ka overexpression o p53 i loko o nā pūnaewele Hep3B i ka pākēneka kiʻekiʻe o nā cell vacuoles i hoʻoulu ʻia e ka galangin i nā pae maʻamau [2].
Hoʻokolo Pūnaewele
Hoʻopili ʻia nā kelepona (5.0 × 103) a mālama ʻia me nā manaʻo like ʻole o ka galangin i loko o 96 mau papa punawai no nā manawa like ʻole.Ma ka hoʻohui ʻana i 10 μ L o 5 mg / ml MTT solution e hoʻoholo ai i ka helu o nā cell ola i kēlā me kēia luawai.Ma hope o ka incubation ma 37 ℃ no 4 mau hola, ua hoʻoheheʻe ʻia nā cell i 100% solution i loaʻa ka 20% SDS a me 50% dimethylformamide μL solution.Ua helu ʻia ka mānoanoa optical me ka varioskan flash reader spectrophotometer ma kahi hawewe hoʻāʻo o 570 nm a me kahi hawewe kuhikuhi o 630 nm.