Galangin CAS No. 548-83-4
sifooyinka jirka iyo kiimikaad
Magaciisa:Gaoliang Curcumin;3,5,7-trihydroxyflavone,
Magaca Ingiriisiga:galangin,
Ingiriis oo loo yaqaan:3,5,7-trihydroxyflavone;3,5,7-trihydroxy-2-phenylchromen-4-kow
Qaab-dhismeedka Molecular
1. Tilmaanta dib u soo celinta Molar: 69.55
2. Mugga molar (m3 / mol): 171.1
3. Isotonic mugga gaarka ah (90.2k): 519.4
4. Dusha sare (dyne / cm): 84.9
5. Polarizability (10-24cm3): 27.57
Kiimikada Xisaabinta
1. Qiimaha tixraaca ee xisaabinta halbeegga hydrophobic (xlopp): Midna
2. Tirada ku-deeqayaasha dammaanadda hydrogen-ka: 3
3. Tirada dabaylaha hydrogen-ka: 5
4. Tirada curaarta kiimikaad ee wareegta: 1
5. Tirada tatoorada: 24
6. Meesha dusha sare ee molicular polarity 87
7. Tirada atamka culus: 20
8. Lacagta dusha sare: 0
9. Kakanaanta: 424
10. Tirada atamka isotopic: 0
11. Go'aami tirada atomiga stereocenters: 0
12. Tirada aan la hubin ee stereocenters atomi: 0
13. Go'aami tirada curaarta kiimikada stereocenters: 0
14. Tirada stereocenter-ka curaarta kiimikada aan la cayimin: 0
15. Tirada cutubyada dabaajiga ah: 1
Falka dawooyinka
Galangin waxa uu wax ka bedeli karaa Salmonella typhimurium TA98 iyo TA100 waxana uu leeyahay saamayn fayraska
In Vitro Barashada
Galangin wuxuu hakiyay catabolism-ka DMBA qaab ku-tiirsanaan ah.Galangin waxa kale oo uu hakiyay samaynta DMBA-DNA-ducts oo uu ka hortagay DMBA ka-hortagga koritaanka unugyada.Unugyada saxda ah iyo microsomes ka go'doonsan unugyada DMBA ee la daweeyay, galangin waxay soo saartay xannibaad ku-tiirsanaan waxtar leh ee waxqabadka CYP1A1 oo lagu qiyaaso waxqabadka ethoxypurine-o-deacetylase.Falanqaynta kinetics-ka-hortagga ee jaantuska laba-geesoodka ah ayaa muujiyay in galangin uu joojiyay dhaqdhaqaaqa CYP1A1 si aan tartan ahayn.Galangin waxay keenaysaa korodhka heerka CYP1A1 mRNA, taasoo muujinaysa inay noqon karto agonist of reseptor hydrocarbon, laakiin waxay joojisaa CYP1A1 mRNA (TCDD) oo ay keentay DMBA ama 2,3,5,7-tetrachlorodibenzo-p-dioxin.Galangin waxa kale oo uu hor istaagaa DMBA ama TCDD qoraal-ku-qoris oo ku saabsan vectors-ka weriyeyaasha ka kooban CYP1A1 dhiirrigeliye [1].Daaweynta Galangin waxay joojisay kororka unugyada waxayna keentay autophagy (130) μM) Iyo apoptosis (370 μM) 3, iyo (3) korodhka boqolkiiba unugyada leh vacuoles, P53 muujinta ayaa sidoo kale kor u kacday, Galangin induced autophagy waxaa lagu yareeyey xakamaynta p53 ee unugyada HepG2, iyo xad-dhaafka p53 ee unugyada Hep3B waxay dib u soo celisay boqolkiiba sare ee vacuoles unugyo ay keentay galangin heerar caadi ah. [2].
Tijaabada Unugyada
Unugyada (5.0 × 103) ayaa lagu tallaalay oo lagu daweeyay uruurin kala duwan oo galangin ah 96 saxan oo ceel ah waqtiyo kala duwan.Marka lagu daro 10 μ L ee 5 mg / ml MTT xal si loo go'aamiyo tirada unugyada nool ee ceel kasta.Ka dib markii la kariyey at 37 ℃ muddo 4 saacadood ah, unugyada waxaa lagu milmay 100% xal ka kooban 20% SDS iyo 50% dimethylformamide μL xal.Cufnaanta indhaha ayaa lagu qiyaasey iyadoo la isticmaalayo spectrophotometer varioskan flash reader spectrophotometer dhererka tijaabada ah 570 nm iyo mawjadda tixraaca ee 630 nm.
