Galangin CAS No. 548-83-4
Zvenyama uye zvemakemikari zvinhu
Zita rezita:Gaoliang Curcumin;3,5,7-trihydroxyflavone,
Chirungu Zita:galangin,
Zita rechirungu:3,5,7-trihydroxyflavone;3,5,7-trihydroxy-2-phenylchromen-4-imwe
Molecular Structure
1. Molar refractive index: 69.55
2. Molar volume (m3 / mol): 171.1
3. Isotonic chaiyo vhoriyamu (90.2k): 519.4
4. Kushungurudzika kwepamusoro (dyne / cm): 84.9
5. Polarizability (10-24cm3): 27.57
Computational Chemistry
1. Reference value ye hydrophobic parameter calculation (xlogp): Hapana
2. Nhamba yevanopa hydrogen bond: 3
3. Nhamba yehydrogen bond receptors: 5
4. Nhamba yezvisungo zvemakemikari zvinotenderera: 1
5. Nhamba yematautomers: 24
6. Topological molecular polarity surface area 87
7. Nhamba yemaatomu anorema: 20
8. Surface charge: 0
9. Kuoma kunzwisisa: 424
10. Nhamba ye isotopic maatomu: 0
11. Sarudza nhamba yeatomic stereocenters: 0
12. Nhamba yeatomic stereocenters asina chokwadi: 0
13. Sarudza huwandu hwemakemikari bond stereocenters: 0
14. Nhamba ye indeterminate chemical bond stereocenters: 0
15. Nhamba yecovalent bond units: 1
Pharmacological Action
Galangin inogona kuchinja Salmonella typhimurium TA98 uye TA100 uye ine antiviral effect.
In Vitro Kudzidza
Galangin inhibited the catabolism yeDMBA nenzira inoenderana nedosi.Galangin zvakare yakarambidza kuumbwa kweDMBA-DNA adducts uye yakadzivirira DMBA yakakonzera masero kukura inhibition.Mumasero akasimba uye mamicrosomes akaparadzaniswa kubva kuDMBA akarapwa maseru, galangin yakagadzira inoshanda-inotsamira dosed inhibition yeCYP1A1 chiitiko chinoyerwa ne ethoxypurine-o-deacetylase chiitiko.Kuongororwa kweinhibition kinetics nekaviri reciprocal diagram yakaratidza kuti galangin inhibited CYP1A1 chiitiko nenzira isina kukwikwidza.Galangin inotungamirira kukuwedzera kweCYP1A1 mRNA level, zvichiratidza kuti inogona kunge iri agonist yekunhuhwirira kwehydrocarbon receptor, asi inodzivisa CYP1A1 mRNA (TCDD) inokonzerwa neDMBA kana 2,3,5,7-tetrachlorodibenzo-p-dioxin.Galangin zvakare inhibisa DMBA kana TCDD induced transcription ye reporter vectors ine CYP1A1 mutsigiri [1].Galangin kurapwa kwakadzivirira kupararira kwesero uye induced autophagy (130) μ M) Uye apoptosis (370 μ M) Kunyanya, kurapwa kwegalangi mumasero eHepG2 kwakakonzera (1) kuunganidzwa kwe autophagosomes, (2) kuwedzera mazinga e microtubule akabatana neprotein light chain. 3, uye (3) yakawedzera muzana yemasero ane vacuoles. P53 kutaura kwakawedzerawo. [2].
Sero Kuedza
Masero (5.0 × 103) anoculated uye anobatwa neakasiyana-siyana egalangin mu96 tsime mahwendefa kwenguva dzakasiyana.Nekuwedzera 10 μ L ye5 mg / ml MTT mhinduro yekuona huwandu hwemasero mapenyu mutsime rega rega.Mushure mekuvhara pa 37 ℃ kwemaawa mana, masero akanyungudutswa mu100% mhinduro ine 20% SDS uye 50% dimethylformamide μ L mhinduro.The optical density yakaverengerwa pachishandiswa varioskan flash reader spectrophotometer pabvunzo wavelength ye570 nm uye referensi wavelength ye630 nm.
