Galangin CAS Nọmba 548-83-4
Njirimara anụ ahụ na kemịkal
Aha aha:Gaoliang Curcumin;3,5,7-trihydroxyflavone,
Aha Bekee:galangin,
utu Bekee:3,5,7-trihydroxyflavone;3,5,7-trihydroxy-2-phenylchromen-4-otu
Ọdịdị Molecular
1. Ndekọ ntugharị molar: 69.55
2. Mpịakọta olu (m3 / mol): 171.1
3. Isotonic kpọmkwem olu (90.2k): 519.4
4. Esemokwu dị n'elu (dyne / cm): 84.9
5. Polarizability (10-24cm3): 27.57
Chemistry Mgbakọ
1. Ntụaka uru maka hydrophobic parameter ngụkọta oge (xlopp): Ọ dịghị
2. Ọnụọgụ nke ndị na-enye njikọ njikọ hydrogen: 3
3. Ọnụọgụ nke ndị nnabata hydrogen: 5
4. Ọnụọgụ nke njikọ kemịkalụ rotatable: 1
5. Ọnụ ọgụgụ ndị na-akpụ akpụ: 24
6. Topological molecular polarity surface area 87
7. Ọnụọgụ nke atọm arọ: 20
8. Ụgwọ elu: 0
9. Mgbagwoju anya: 424
10. Ọnụọgụ nke atọm isotopic: 0
11. Kpebie ọnụ ọgụgụ nke atọm stereocenters: 0
12. Ọnụọgụ nke stereocenter atomic na-ejighị n'aka: 0
13. Kpebie ọnụọgụ kemịkalụ stereocenters: 0
14. Ọnụọgụ nke stereocenter kemịkalụ na-enweghị njedebe: 0
15. Ọnụọgụ nke covalent bond units: 1
Ihe omume ọgwụ
Galangin nwere ike gbanwee Salmonella typhimurium TA98 na TA100 ma nwee mmetụta antiviral.
Na Vitro Ọmụmụ
Galangin gbochiri catabolism nke DMBA n'ụzọ dabere na dose.Galangin gbochiri guzobe DMBA-DNA adducts ma gbochie DMBA butere mgbochi mkpụrụ ndụ.N'ime mkpụrụ ndụ na-adịghị emebi emebi na microsomes dịpụrụ adịpụ na sel DMBA a na-emeso ya, galangin na-emepụta ihe mgbochi na-adabere na dose nke ọrụ CYP1A1 nke a tụrụ site na ọrụ ethoxypurine-o-deacetylase.Nyocha nke kinetics mgbochi site na eserese nkwụghachi ugboro abụọ gosiri na galangin gbochiri ọrụ CYP1A1 n'ụzọ enweghị asọmpi.Galangin na-eduga na mmụba nke ọkwa CYP1A1 mRNA, na-egosi na ọ nwere ike ịbụ agonist nke aromatic hydrocarbon receptor, ma ọ na-egbochi CYP1A1 mRNA (TCDD) nke DMBA ma ọ bụ 2,3,5,7-tetrachlorodibenzo-p-dioxin kpatara.Galangin na-egbochikwa DMBA ma ọ bụ TCDD transcript nke ndị nta akụkọ nwere onye na-akwalite CYP1A1 [1].Ngwọta Galangin gbochiri mgbasawanye cell na ịkpata autophagy (130) μM) na apoptosis (370 μM) . Karịsịa, ọgwụgwọ galangin na mkpụrụ ndụ HepG2 mere ka (1) nchịkọta nke autophagosomes, (2) ụbara ọkwa nke microtubule jikọtara protein ìhè yinye. 3, na (3) ụbara pasent nke mkpụrụ ndụ nwere vacuoles. P53 okwu mụbara. Galangin induced autophagy na-ebelata site na igbochi p53 na sel HepG2, na oke p53 na sel Hep3B weghachiri pasent dị elu nke cell vacuoles nke galangin kpatara na ọkwa nkịtị. [2].
Nnwale cell
Selụ (5.0 × 103) gbanyere ma mesoo ya dị iche iche nke galangin na efere ọma 96 maka oge dị iche iche.Site na ịgbakwunye 10 μ L nke 5 mg / ml MTT ngwọta iji chọpụta ọnụ ọgụgụ nke mkpụrụ ndụ dị ndụ na nke ọ bụla.Mgbe incubation na 37 ℃ maka awa 4, sel agbazere na 100% ngwọta nwere 20% SDS na 50% dimethylformamide μL ngwọta.Achọpụtara njupụta anya ahụ site na iji spectrophotometer varioskan flash reader na nlegharị anya ule nke 570 nm yana ogologo ntụgharị ntụaka nke 630 nm.
