Jujuboside A CAS No.. 55466-04-1
Émbaran ésénsial
landian Cina:jujube kernel saponin A, jujube kernel saponin A;Jujube kernel saponin A (standar)
Ngaran Inggris:Jujuboside A
Sumber tutuwuhan:asalna tina siki jujube liar, ogé katelah kernel jujube sareng inti jujube liar
Rumus molekul:C58H94O26
Beurat molekular:1207.35
CAS No.55466-04-1
Bioaktivitas Jujuboside A
Sasaran:Reséptor GABA, mTOR, PI3K, Akt [1] [2]
Ulikan in vitro:dosis low 41 μ Jujuboside A of M (kira 0,05 g / L) ngainduksi GABA (a) reséptor salila 24 na 72 h perlakuan α 1, α 5, β 2 subunit mRNA ngaronjat sacara signifikan.Dosis tinggi 82 μ M (kira-kira 0,1 g / L) Jujuboside A nyata ningkat reséptor GABA (a) dina 24 h α 1, α 5 tingkat subunit mRNA jeung turun β 2 subunit tingkat mRNA jeung turun GABA (a) subunit reséptor α 1， Éksprési β2 mRNA dirawat dina 72 jam [1].Jujuboside A pretreatment tiasa ngabalikeun panurunan viability sél jeung hadé ngainduksi ISO ngainduksi tatu sél H9c2.Jujuboside A tiasa ngagancangkeun fosforilasi PI3K, Akt sareng mTOR.Jujuboside A nyata bisa ngurangan proporsi microtubule pakait protéin LC3-II / I dina sél H9c2 [2]
Studi in vivo:beurang (9:00-15:00), jujubosides nyata ngaronjat total sare jeung gerakan panon gancang (REM) sare, tapi teu boga pangaruh signifikan dina non REM (NREM) sare.Peuting (21:00-3:00), jujubosides nyata ngaronjat total sare jeung NREM sare, utamana hampang sare, tapi teu boga pangaruh signifikan dina sare REM jeung slow wave sleep (SWS) [3].perlakuan Intraventricular kalawan jjuboside a ieu nyata alleviated ku ngaliwatan Y-maze, dijauhkeun aktip tur Morris ukuran Maze cai β 1-42 ngainduksi learning jeung impairment memori dina mencit.Suntikan intracerebroventricular Jujuboside A turun tingkat hippocampal a β 1-42 sacara signifikan ngahambat kagiatan acetylcholinesterase (AChE) sareng henteu, sareng ngirangan paningkatan eusi malondialdehida (MDA) dina hippocampus sareng korteks cerebral mencit disuntik kana ventrikel gurat β 1-42. [4].
percobaan sél:saatos 7 dinten kultur in vitro, sél terus-terusan kakeunaan 24 jam atanapi 72 jam, sareng henteu kakeunaan médium anu ngandung Jujuboside A atanapi diazepam atanapi duanana.Véktor ditambahkeun kana grup kontrol;Grup Diazepam ditambahkeun 10 μ M diazepam;Jujuboside A82 μ M (kira-kira 0.1g / L) jeung 41 μ M (kira-kira 0.05 g / L) ditambahkeun kana jua-h (dosis tinggi Jujuboside A) jeung jua-l (dosis low Jujuboside A) grup, masing-masing.Total RNA diisolasi tina sél pikeun analisis salajengna [1].
percobaan sato:mencit: a ieu nyuntik ngaliwatan ICV β 1-42 ngainduksi impairment kognitif di mencit.Lajeng, mencit disuntik kalawan Jujuboside A (0,02 jeung 0,2 mg / kg) intraventricular (ICV) salila 5 poé.Y maze, dijauhkeun aktip sareng tés maze cai Morris dilakukeun dina beurit [1].
Alias Inggris tina Jujuboside A
α-L-arabinopyranoside, (3β,16β,23R) -16,23:16,30-diepoxy-20-hydroxydammar-24-en-3-yl O-6-deoxy-α-L-mannopyranosyl-(1- >2)-O-[O-β-D-glucopyranosyl-(1->6)-O-[β-D-xylopyranosyl-(1->2)]-β-D-glucopyranosyl-(1->3 )]-
(3β,16β,23R)-20-Hydroxy-16,23:16,30-diepoxydammar-24-en-3-yl 6-déoxy-α-L-mannopyranosyl-(1->2)-[β-D -glucopyranosyl-(1->6)-[β-D-xylopyranosyl-(1->2)]-β-D-glucopyranosyl-(1->3)]-α -L-arabinopyranoside
jujuboside C
α-L-Arabinopyranoside, (3β,16β,23R)-16,23:16,30-diepoxy-20-hydroxydammar-24-en-3-yl O-6-deoxy-α-L-mannopyranosyl-(1- >2)-O-[O-β-D-glucopyranosyl-(1->6)-O-[β-D-xylopyranosyl-(1->2)]- β-D-glucopyranosyl-(1->3 )]-
JujubosideA
(3β,16β,23R)-20-Hydroxy-16,23:16,30-diepoxydammar-24-en-3-yl 6-déoxy-α-L-mannopyranosyl-(1->2)-[β-D -glucopyranosyl-(1->6)-[β-D-xylopyranosyl-(1->2)]-β-D-glucopyranosyl-(1->3)]-α-L-arabinopyranoside
