Jujuboside A CAS No. 55466-04-1
Notitia essentialis
Seres alias:jujube nuclei saponin A, jujube nuclei saponin A;Jujube kernel saponin A (standard)
Nomen Anglicum:Jujuboside A
Fons plantarum:fit ex seminibus jujube silvestrium, etiam quae dicitur nucleus jujube et silvestris jujube core
Formulae hypotheticae:C58H94O26
Pondus hypotheticum:1207.35
CAS Non.55466-04-1
Bioactivity de Jujuboside A
Scopum:GABA receptor, mTOR, PI3K, Akt [1] [2]
In vitro studio;humilis dosis 41 μ Jujuboside A of M (circiter 0.05 g / L) receptores in 24 et 72 h receptores inductos α 1， α 5， β 2 laevis variante auctus est.Maximum dosis 82 μ M (circiter 0,1 g / L) Jujuboside A receptacula insigniter aucta GABA (a) receptacula in 24 h α 1， α 5 subunit variant gradus et decrescentes β 2 subunit variant GABA (a) receptacula subunita α 1， β 2 variant phrasis tractata 72 h [1].Jujuboside A praetractatio decrementum cellae viability invertere potest et ISO melius induci iniuriam cellae H9c2.Jujuboside A accelerare potest phosphorylationem PI3K, Akt et mTOR.Jujuboside A signanter reducere potest proportionem microtubuli adiuncti dapibus LC3-II / I in cellulis H9c2 [2].
in studio vivo;interdiu (9:00-15:00), jujubosides signanter augentur somnus totalis et celeris oculi motus (REM) somnus, sed nullum momentum in non REM (NREM) somnus habuit.Nocte (21:00-3:00), jujubosides signanter augentur totalem somnum et NREM somnus, praesertim lenis somnus, sed nihil significant effectus in REM somno et in unda tardus ad somnum (SWS) [3].Curatio intraventricularis cum jjuboside a signanter sublevata est per Y-maze, activa fuga et Morris aqua mensurarum errorum β 1-42 inducta doctrina et memoria detrimentum in muribus.Iniectio intracerebroventricularis de Jujuboside A β 1-42 gradus hippocampalorum decrevit signanter actiones acetylcholinesterasis (ACHE) et nullas inhibuit, et auctum in hippocampi malindialdehydis (MDA) contentum decrevit et cortex cerebri murium in ventriculum lateralem injectum β 1-42 [4]。
Experimentum cellae:post 7 dies culturae in vitro, cellae continue expositae sunt per 24 horas vel 72 horas, nec expositae erant medio continenti Jujuboside A vel diazepam vel utrumque.Vector ad imperium coetus adiectus est;Circulus diazepam adiecit 10 µ M diazepam;Jujuboside A82 µ M (circa 0.1g/L) et 41 µ M (circiter 0.05 g/L) addita est jua-h (dosis altitudinis A) et jua-l (dosis humilis A jujuboside) coetus respective.Totalis RNA a cellulis ad ulteriorem analysim separata est [1].
Experimentum animale:mures: a injecta per ICV β 1-42 inducta cognitiva indigestione murium.Mures deinde intraventriculares (ICV) per 5 dies injecti sunt (0.02 et 0,2 mg / kg).Y maze, fuga activa et Mauricius aqua probata error fiebat in muribus [1].
Anglicus Alias of Jujuboside A
α-L-arabinopyranoside,(3β,16β,23R)-16,23:16,30-diepoxy-20-hydroxydammar-24-en-3-yl O-6-deoxy-α-L-mannopyranosyl-(1- >2)-O. )]-
( 3 β, 16β,23R)-20-Hydroxy-16,23:16,30-diepoxydammar-24-en-3-yl 6-deoxy-α-L-mannopyranosyl-(1->2)-[β-D -glucopyranosyl-(1->6)-[β-D-xylopyranosyl-(1->2)]-β-D-glucopyranosyl-(1->3)]-α -L-arabinopyranosyl.
jujuboside C
α-L-Arabinopyranoside,(3β,16β,23R)-16,23:16,30-diepoxy-20-hydroxydammar-24-en-3-yl O-6-deoxy-α-L-mannopyranosyl-(1- >2)-O. )]-
JujubosideA
( 3 β, 16β,23R)-20-Hydroxy-16,23:16,30-diepoxydammar-24-en-3-yl 6-deoxy-α-L-mannopyranosyl-(1->2)-[β-D -glucopyranosyl-(1->6)-[β-D-xylopyranosyl-(1->2)]-β-D-glucopyranosyl-(1->3)]
