Jujuboside A CAS No.: 55466-04-1
Cov ntaub ntawv tseem ceeb
Suav alias:jujube ntsiav saponin A, jujube kernel saponin A;Jujube kernel saponin A (tus qauv)
Lub npe Askiv:Jujuboside A
Qhov chaw cog:Nws yog los ntawm cov noob ntawm qus jujube, tseem hu ua jujube kernel thiab qus jujube core.
Molecular formula:C58H94O26
Molecular Luj:1207.35 Nws
CAS Nr.55466-04-1
Bioactivity ntawm Jujuboside A
Hom phiaj:GABA receptor, mTOR, PI3K, Akt [1] [2]
Kev tshawb nrhiav hauv vitro:koob tshuaj tsawg 41 μ Jujuboside A ntawm M (txog 0.05 g / L) induced GABA (a) receptors thaum 24 thiab 72 h kev kho mob α 1, α 5, β 2 subunit mRNA nce ntau.Cov koob tshuaj siab 82 μ M (kwv yees 0.1 g / L) Jujuboside A nce ntxiv GABA (a) receptors ntawm 24 h α 1, α 5 subunit mRNA qib thiab txo qis β 2 subunit mRNA qib thiab txo GABA (a) receptor subunit α 1, β 2 mRNA qhia tau kho ntawm 72 h [1].Jujuboside Kev kho ua ntej tuaj yeem thim rov qab txo qis ntawm cell viability thiab zoo dua induce ISO induced H9c2 cell raug mob.Jujuboside A tuaj yeem ceev cov phosphorylation ntawm PI3K, Akt thiab mTOR.Jujuboside A tuaj yeem txo qhov kev faib ua feem ntawm microtubule txuam nrog cov protein LC3-II / I hauv H9c2 hlwb [2]
Hauv kev tshawb nrhiav vivo:thaum nruab hnub (9:00-15:00), jujubosides tau nce tag nrho pw tsaug zog thiab ceev qhov muag txav (REM) pw tsaug zog, tab sis tsis muaj qhov cuam tshuam tseem ceeb rau kev pw tsaug zog tsis yog REM (NREM).Thaum tsaus ntuj (21: 00-3: 00), jujubosides tau nce tag nrho kev pw tsaug zog thiab NREM pw tsaug zog, tshwj xeeb tshaj yog pw tsaug zog, tab sis tsis muaj qhov cuam tshuam rau REM pw tsaug zog thiab pw tsaug zog qeeb (SWS) [3].Kev kho mob intraventricular nrog jjuboside a tau txo qis los ntawm Y-maze, kev tiv thaiv kev ua haujlwm thiab Morris dej maze ntsuas β 1-42 induced kev kawm thiab kev nco tsis zoo hauv cov nas.Kev txhaj tshuaj Intracerebroventricular ntawm Jujuboside A txo qis hippocampal a β 1-42 qib cuam tshuam rau kev ua haujlwm ntawm acetylcholinesterase (AChE) thiab tsis muaj, thiab txo qis cov ntsiab lus ntawm malondialdehyde (MDA) hauv hippocampus thiab cerebral cortex ntawm cov nas tsuag 1-2 β ob sab. [4].
Kev sim ntawm tes:Tom qab 7 hnub ntawm kab lis kev cai nyob rau hauv vitro, lub hlwb raug txuas ntxiv mus rau 24 teev lossis 72 teev, thiab tsis raug rau qhov nruab nrab uas muaj Jujuboside A lossis diazepam lossis ob qho tib si.Vector tau ntxiv rau pawg tswj hwm;Diazepam pawg ntxiv 10 μ M diazepam;Jujuboside A82 μ M (kwv yees 0.1g / L) thiab 41 μ M (kwv yees 0.05 g / L) tau ntxiv rau jua-h (siab koob tshuaj Jujuboside A) thiab jua-l (tsawg koob Jujuboside A) pawg, feem.Tag nrho RNA raug cais tawm ntawm cov hlwb rau kev tshuaj xyuas ntxiv [1].
Tsiaj kev sim:nas: ib tug tau txhaj los ntawm ICV β 1-42 induced cognitive impairment nyob rau hauv nas.Tom qab ntawd, cov nas tau txhaj tshuaj Jujuboside A (0.02 thiab 0.2 mg / kg) intraventricular (ICV) rau 5 hnub.Y maze, nquag zam thiab Morris dej maze kuaj tau ua rau nas [1].
English Alias ntawm Jujuboside A
α-L-arabinopyranoside, (3β,16β,23R)-16,23:16,30-diepoxy-20-hydroxydammar-24-en-3-yl O-6-deoxy-α-L-mannopyranosyl-(1- >2)-O-[O-β-D-glucopyranosyl-(1->6)-O-[β-D-xylopyranosyl-(1->2)]-β-D-glucopyranosyl-(1->3) )]-
(3β,16β,23R)-20-Hydroxy-16,23:16,30-diepoxydammar-24-en-3-yl 6-deoxy-α-L-mannopyranosyl-(1->2)-[β-D -glucopyranosyl-(1->6)-[β-D-xylopyranosyl-(1->2)]-β-D-glucopyranosyl-(1->3)]-α -L-arabinopyranoside
jujuboside C
α-L-Arabinopyranoside, (3β,16β,23R)-16,23:16,30-diepoxy-20-hydroxydammar-24-en-3-yl O-6-deoxy-α-L-mannopyranosyl-(1- >2)-O-[O-β-D-glucopyranosyl-(1->6)-O-[β-D-xylopyranosyl-(1->2)]- β-D-glucopyranosyl-(1->3) )]-
JujubosideA
(3β,16β,23R)-20-Hydroxy-16,23:16,30-diepoxydammar-24-en-3-yl 6-deoxy-α-L-mannopyranosyl-(1->2)-[β-D -glucopyranosyl-(1->6)-[β-D-xylopyranosyl-(1->2)]-β-D-glucopyranosyl-(1->3)]-α-L-arabinopyranoside
