Jujuboside A CAS Nama 55466-04-1
Nga korero tino nui
ingoa ingoa Hainamana:Jujube kernel saponin A, jujube kernel saponin A;Jujube kernel saponin A (paerewa)
Ingoa Ingarihi:Jujuboside A
Pūtake tipu:ka puta mai i nga kakano o te jujube mohoao, e mohiotia ana ano he kakano jujube me te matua jujube mohoao
tātai rāpoi:C58H94O26
Taumaha rāpoi:1207.35
CAS No.55466-04-1
Ko te koiora o Jujuboside A
Whāinga:Kaiwhiwhi GABA, mTOR, PI3K, Akt [1] [2]
Te ako in vitro:horopeta iti 41 μ Jujuboside A o M (e pā ana ki 0.05 g / L) whakaawe GABA (a) receptors i roto i 24 me 72 h maimoatanga α 1， α 5， β 2 subunit mRNA nui haere tino.Te horopeta teitei 82 μ M (mo te 0.1 g / L) Jujuboside He tino whakanui ake i nga kaiutuutu GABA (a) i te 24 h α 1， α 5 taumata iti mRNA me te whakaheke i te taumata β 2 subunit mRNA me te heke iho o te GABA (a) te tango i nga waahanga α 1， I rongoahia te whakaaturanga β2 mRNA i te 72 haora [1].Jujuboside Ka taea e te maimoatanga o mua te huri i te hekenga o te oranga o te pūtau me te pai ake te whakararu i te whara o te pūtau H9c2 a ISO.Ka taea e Jujuboside A te whakatere i te phosphorylation o PI3K, Akt me te mTOR.Ka taea e Jujuboside A te whakaiti i te wahanga o te microtubule e pa ana ki te pūmua LC3-II / I i roto i nga pūtau H9c2 [2]
Te ako i roto i te vivo:i te awatea (9:00-15:00), i tino whakanuia e te jujubosides te moe katoa me te moe tere o te nekehanga kanohi (REM), engari kaore he painga nui ki te moe kore REM (NREM).I te po (21:00-3:00), ka tino whakanuia e te jujubosides te moe katoa me te moe NREM, ina koa te moe ngawari, engari kaore he painga nui ki te moe REM me te moe ngaru puhoi (SWS) [3].Ko te maimoatanga intraventricular me te jjubosside a i tino whakahekehia e te Y-maze, te karo kaha me te inenga maze wai Morris β 1-42 te ako me te ngoikore o te mahara ki nga kiore.Intracerebroventricular injection of Jujuboside A heke hippocampal a β 1-42 taumata tino aukati i nga mahi o te acetylcholinesterase (AChE) me te kore, me te whakaheke i te nui o te ihirangi o te malondialdehyde (MDA) i roto i te hippocampus me te uho roro o nga kiore i werohia ki roto i te ventricle lateral β 1-42. [4].
Whakamātau pūtau:i muri i nga ra 7 o te ahurea i roto i te vitro, ka noho tonu nga ruma mo te 24 haora, 72 haora ranei, a kaore i kitea ki te reo kei roto i te Jujuboside A te diazepam ranei e rua.I taapirihia te Vector ki te roopu whakahaere;Ko te roopu Diazepam i tapirihia te 10 μ M diazepam;Ko te Jujuboside A82 μ M (mo te 0.1g / L) me te 41 μ M (mo te 0.05 g / L) i tapirihia ki nga roopu jua-h (Jujuboside A te horopeta teitei) me te jua-l (Jujuboside A iti te horopeta).Ko te RNA katoa i wehea mai i nga pūtau mo te tātaritanga ake [1].
Whakamātau kararehe:kiore: i werohia a a na roto i te ICV β 1-42 na te ngoikoretanga o te hinengaro i roto i nga kiore.Na, ka werohia nga kiore ki te Jujuboside A (0.02 me te 0.2 mg / kg) intraventricular (ICV) mo nga ra e 5.I mahia te maze Y, te karo kaha me nga whakamatautau maze wai Morris ki nga kiore [1].
Ingoa Ingarihi o Jujuboside A
α-L-arabinopyranoside, (3β,16β,23R)-16,23:16,30-diepoxy-20-hydroxydammar-24-en-3-yl O-6-deoxy-α-L-mannopyranosyl-(1- >2)-O-[O-β-D-glucopyranosyl-(1->6)-O-[β-D-xylopyranosyl-(1->2)]-β-D-glucopyranosyl-(1->3 )]-
(3β,16β,23R)-20-Hydroxy-16,23:16,30-diepoxydammar-24-en-3-yl 6-deoxy-α-L-mannopyranosyl-(1->2)-[β-D -glucopyranosyl-(1->6)-[β-D-xylopyranosyl-(1->2)]-β-D-glucopyranosyl-(1->3)]-α -L-arabinopyranoside
jujuboside C
α-L-Arabinopyranoside, (3β,16β,23R)-16,23:16,30-diepoxy-20-hydroxydammar-24-en-3-yl O-6-deoxy-α-L-mannopyranosyl-(1- >2)-O-[O-β-D-glucopyranosyl-(1->6)-O-[β-D-xylopyranosyl-(1->2)]- β-D-glucopyranosyl-(1->3 )]-
JujubosideA
(3β,16β,23R)-20-Hydroxy-16,23:16,30-diepoxydammar-24-en-3-yl 6-deoxy-α-L-mannopyranosyl-(1->2)-[β-D -glucopyranosyl-(1->6)-[β-D-xylopyranosyl-(1->2)]-β-D-glucopyranosyl-(1->3)]-α-L-arabinopyranoside
