Salvianolic acid C
Chinangwa
Salvianolic acid C is a non competitive inhibitor ye cytochrome p4502c8 (cyp2c8) uye yakasanganiswa inhibitor ye cytochrome P4502J2 (CYP2J2) ine simba repakati.Hwaro hwayo hweKi hwe cyp2c8 uye CYP2J2 ndeye 4.82 zvakateerana μ M uye 5.75 μ M
Shona Name
(2R) -3-(3,4-Dihydroxyphenyl) -2-({(2E)-3-[2-(3,4-dihydroxyphenyl)- 7-hydroxy-1-benzofuran-4-yl]-2- propenoyl}oxy)propanoic acid
Vadivelu Comedy English Alias
(2R) -3-(3,4-Dihydroxyphenyl) -2-({(2E)-3-[2-(3,4-dihydroxyphenyl)-7-hydroxy-1-benzofuran-4-yl]prop-2 -enoyl}oxy)propanoic acid
(2R)-3-(3,4-Dihydroxyphenyl)-2-({(2E)-3--[2-(3,4-dihydroxyphenyl)-7-hydroxy-1-benzofuran-4-yl]-2- propenoyl}oxy)propanoic acid
Benzenepropanoic acid, α--[[(2E)-3-[2-(3,4-dihydroxyphenyl)-7-hydroxy-4-benzofuranyl]-1-oxo-2-propen-1-yl]oxy]-3, 4-dihydroxy-, (αR)-
Salvianolic acid C
Physicochemical Properties yeSalvianolic Acid C
Density: 1.6 ± 0.1 g / cm3
Boiling Point: 844.2 ± 65.0 ° C pa 760 mmHg
Molecular Formula: C26H20O10
Molecular uremu: 492.431
Flash point: 464.4 ± 34.3 ° C
Chaiyo Misa: 492.105652
PSA:177.89000
LogP: 3.12
Steam Pressure: 0.0 ± 3.3 mmHg pa25 ° C
Refractive index: 1.752
Bioactivity yeSalvianolic Acid C
Tsanangudzo:
Salvianolic acid C is a non competitive inhibitor ye cytochrome p4502c8 (cyp2c8) uye yakasanganiswa inhibitor ye cytochrome P4502J2 (CYP2J2) ine simba repakati.Yayo Ki tsika dze cyp2c8 uye CYP2J2 4.82 zvakateerana μ M uye 5.75 μ M.
Zvikamu zvinoenderana:
Chiratidzo nzira>> metabolic enzyme / protease>> cytochrome P450
Tsvagiridzo > > gomarara
Natural Products > > vamwe
Chinangwa:
CYP2C8:4.82 μM (Ki)
CYP2J2:5.75 μM (Ki)
In Vitro Chidzidzo:
Salvianolic acid C ine mwero yakasanganiswa inhibitor yeasina kukwikwidza cyp2c8 inhibitor uye CYP2J2.Iyo KIS ye cyp2c8 uye CYP2J2 ndeye 4.82 uye 5.75 zvakateerana μ M [1]。 1 uye 5 μ M salvianolic acid C (SALC) inogona kuvharisa zvakanyanya LPS inokonzerwa hapana kugadzirwa.Salvianolic acid C yakaderedza zvakanyanya kutaura kweNOS.Salvianolic acid C inhibits LPS yakakonzera TNF- α, IL-1 β, IL-6 uye IL-10 yakanyanyisa.Salvianolic acid C inhibits LPS yakakonzera NF- κ B activation.Salvianolic acid C yakawedzerawo kutaura kweNrf2 uye HO-1 muBV2 microglia [2].
MuVivo Zvidzidzo:
Salvianolic acid C (20mg / kg) kurapwa kwakaderedza zvakanyanya kutiza latency.Uye zvakare, SALC (10 uye 20 mg / kg) kurapwa kwakawedzera zvakanyanya huwandu hwekuyambuka papuratifomu zvichienzaniswa neboka remuenzaniso reLPS.Kuenzaniswa neboka remuenzaniso, systemic administration ye salvianolic acid C pasi yakagadziriswa uropi TNF- α, IL-1 β Uye IL-6 mazinga.Iwo mazinga eNOS neCOX-2 mucerebral cortex uye hippocampus yemakonzo aive akakwirira kupfuura ayo ari muboka rekutonga, nepo salvianolic acid C kurapwa zvakanyanya pasi kwakadzora cortex uye hippocampus.Salvianolic acid C (5, 10 uye 20 mg / kg) kurapwa kwakawedzera p-ampk, Nrf2, HO-1 uye NQO1 mazinga mumakonzo cerebral cortex uye hippocampus nenzira inoenderana nedosi [2].
Reference:
[1].Xu MJ, nevamwe.Inhibitory Migumisiro yeDanshen zvikamu paCYP2C8 uye CYP2J2.Chem Biol Interact.2018 Jun 1;289:15-22.
[2].Rwiyo J, nevamwe.Kushandiswa kweNrf2 kuisa chiratidzo ne salvianolic acid C inoderedza NF κ B inopindirana nekuvhiringidza mhinduro zvose mu vivo uye mu vitro.Int Immunopharmacol.2018 Oct;63:299-310.
